HUCBCs Increase Angiopoietin 1 and Induce Neurorestorative Effects after Stroke in T1DM Rats

CNS Neuroscience and Therapeutics

Volumn 20, Issue 10, 2014, Pages 935-944

  Yan, Tao ^a,b   Venkat, Poornima ^a,c   Ye, Xinchun ^a,d   Chopp, Michael ^a,c   Zacharek, Alex ^a   Ning, Ruizhuo ^a   Cui, Yisheng ^a   Roberts, Cynthia ^a   Kuzmin Nichols, Nicole ^e   Davis Sanberg, Cyndy ^e   Chen, Jieli ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c OAKLAND UNIVERSITY   (United States)

^d XUZHOU MEDICAL UNIVERSITY   (China)

^e Saneron CCEL Therapeutics Inc ^*  (United States)

Author keywords

HUCBC; Neurorestorative therapy; Stroke; T1DM; Vascular remodeling; White matter remodeling

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SMOOTH MUSCLE ACTIN; ANGIOPOIETIN 1; TOLL LIKE RECEPTOR 2; 2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; ACTIN; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; CYTOKINE; GLUCOSE BLOOD LEVEL; IMMUNOGLOBULIN RECEPTOR;

ANTIINFLAMMATORY ACTIVITY; ARTERY DIAMETER; ARTICLE; BLOOD BRAIN BARRIER; CAPILLARY TUBE; CELL THERAPY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENDOTHELIUM CELL; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; OLIGODENDROGLIA; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL; UMBILICAL CORD BLOOD; VASCULAR REMODELING; WESTERN BLOTTING; WHITE MATTER; ANALYSIS OF VARIANCE; ANIMAL; CELL CULTURE; COMPLICATION; CYTOLOGY; DISEASE MODEL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; INTERMEDIATE FILAMENT; METABOLISM; NEUROLOGIC EXAMINATION; STROKE; TRANSPLANTATION; UMBILICAL VEIN ENDOTHELIAL CELL; WISTAR RAT;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ACTINS; ANALYSIS OF VARIANCE; ANGIOPOIETIN-1; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERMEDIATE FILAMENTS; MALE; NEUROLOGIC EXAMINATION; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; STROKE;

EID: 84908693068     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12307     Document Type: Article

References (54)

1. Idris I, Thomson GA, Sharma JC. Diabetes mellitus and stroke. Int J Clin Pract 2006;60:48-56.
2. Yong M, Kaste M. Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial. Stroke 2008;39:2749-2755.
3. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: A systematic overview. Stroke 2001;32:2426-2432.
4. Chen J, Ye X, Yan T, et al. Adverse effects of bone marrow stromal cell treatment of stroke in diabetic rats. Stroke 2011;42:3551-3558.
5. Haller MJ, Viener HL, Wasserfall C, Brusko T, Atkinson MA, Schatz DA. Autologous umbilical cord blood infusion for type 1 diabetes. Exp Hematol 2008;36:710-715.
6. Jones PM, Courtney ML, Burns CJ, Persaud SJ. Cell-based treatments for diabetes. Drug Discovery Today 2008;13:888-893.
7. Hussain MA, Theise ND. Stem-cell therapy for diabetes mellitus. Lancet 2004;364:203-205.
8. Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman MJ, Skidgel RA. Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS One 2009;4:e4226.
9. Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 2004;35:2390-2395.
10. Park D-H, Willing A, Borlongan C, et al. Human umbilical cord blood cells for stroke. In: Bhattacharya N, Stubblefield P, editors. Regenerative medicine using pregnancy-specific biological substances. London: Springer, 2011; 155-167.
11. Ye X, Chopp M, Cui X, et al. Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. Exp Neurol 2011;232:299-308.
12. Brindle NP, Saharinen P, Alitalo K. Signaling and functions of angiopoietin-1 in vascular protection. Circ Res 2006;98:1014-1023.
13. Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996;87:1171-1180.
14. Zacharek A, Chen J, Cui X, et al. Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab 2007;27:1684-1691.
15. Cui X, Chopp M, Zacharek A, Ye X, Roberts C, Chen J. Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke. Neurobiol Dis 2011;43:285-292.
16. Wang YQ, Song JJ, Han X, et al. Effects of Angiopoietin-1 on inflammatory injury in endothelial progenitor cells and blood vessels. Curr Gene Ther 2014;14:128-135.
17. Chen J, Cui X, Zacharek A, Cui Y, Roberts C, Chopp M. White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke. Stroke 2011;42:445-452.
18. Fiuza C, Bustin M, Talwar S, et al. Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Blood 2003;101:2652-2660.
19. Barile GR, Schmidt AM. RAGE and its ligands in retinal disease. Curr Mol Med 2007;7:758-765.
20. Maillard-Lefebvre H, Boulanger E, Daroux M, Gaxatte C, Hudson BI, Lambert M. Soluble receptor for advanced glycation end products: A new biomarker in diagnosis and prognosis of chronic inflammatory diseases. Rheumatology 2009;48:1190-1196.
21. Ye X, Chopp M, Liu X, et al. Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats. Neuroscience 2011;190:339-345.
22. Chen J, Li Y, Wang L, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001;32:1005-1011.
23. Chen H, Chopp M, Zhang ZG, Garcia JH. The effect of hypothermia on transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1992;12:621-628.
24. Chen J, Sanberg PR, Li Y, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 2001;32:2682-2688.
25. Rogers DC, Campbell CA, Stretton JL, Mackay KB. Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 1997;28:2060-2065.
26. Chen J, Zhang ZG, Li Y, et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 2003;53:743-751.
27. Zacharek A, Chen J, Cui X, Yang Y, Chopp M. Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke 2009;40:254-260.
28. Chen J, Cui X, Zacharek A, et al. Niaspan increases angiogenesis and improves functional recovery after stroke. Ann Neurol 2007;62:49-58.
29. Sanberg PR, Willing AE, Garbuzova-Davis S, et al. Umbilical cord blood-derived stem cells and brain repair. Ann N Y Acad Sci 2005;1049:67-83.
30. Yan T, Chopp M, Ye X, et al. Niaspan increases axonal remodeling after stroke in type 1 diabetes rats. Neurobiol Dis 2012;46:157-164.
31. Font MA, Arboix A, Krupinski J. Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke. Curr Cardiol Rev 2010;6:238-244.
32. Arai K, Lo EH. Oligovascular signaling in white matter stroke. Biol Pharm Bull 2009;32:1639-1644.
33. Mandai K, Matsumoto M, Kitagawa K, et al. Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia. Neuroscience 1997;77:849-861.
34. Chen J, Chopp M. Neurorestorative treatment of stroke: Cell and pharmacological approaches. NeuroRx 2006;3:466-473.
35. Fagiani E, Christofori G. Angiopoietins in angiogenesis. Cancer Lett 2013;328:18-26.
36. Suri C, McClain J, Thurston G, et al. Increased vascularization in mice overexpressing angiopoietin-1. Science 1998;282:468-471.
37. Thurston G, Rudge JS, Ioffe E, et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 2000;6:460-463.
38. Zhang ZG, Zhang L, Croll SD, Chopp M. Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice. Neuroscience 2002;113:683-687.
39. Beck H, Plate KH. Angiogenesis after cerebral ischemia. Acta Neuropathol 2009;117:481-496.
40. Cui X, Chopp M, Zacharek A, Cui Y, Roberts C, Chen J. The neurorestorative benefit of GW3965 treatment of stroke in mice. Stroke 2013;44:153-161.
41. Schmidt AM, Yan SD, Yan SF, Stern DM. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 2001;108:949-955.
42. Hassid BG, Nair MN, Ducruet AF, et al. Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia. J Clin Neurosci 2009;16:302-306.
43. Muhammad S, Barakat W, Stoyanov S, et al. The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci 2008;28:12023-12031.
44. Toth C, Schmidt AM, Tuor UI, et al. Diabetes, leukoencephalopathy and rage. Neurobiol Dis 2006;23:445-461.
45. Shimizu F, Kanda T. [Disruption of the blood-brain barrier in inflammatory neurological diseases]. Brain Nerve 2013;65:165-176.
46. de Vries HE, Kuiper J, de Boer AG, Van Berkel TJ, Breimer DD. The blood-brain barrier in neuroinflammatory diseases. Pharmacol Rev 1997;49:143-156.
47. Borlongan CV, Glover LE, Sanberg PR, Hess DC. Permeating the blood brain barrier and abrogating the inflammation in stroke: Implications for stroke therapy. Curr Pharm Des 2012;18:3670-3676.
48. Denes A, Ferenczi S, Kovacs KJ. Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size. J Neuroinflammation 2011;8:164.
49. Chen B, Friedman B, Cheng Q, et al. Severe blood-brain barrier disruption and surrounding tissue injury. Stroke 2009;40:e666-e674.
50. Zhang L, Zhang ZG, Chopp M. The neurovascular unit and combination treatment strategies for stroke. Trends Pharmacol Sci 2012;33:415-422.
51. Moxon-Emre I, Schlichter LC. Evolution of inflammation and white matter injury in a model of transient focal ischemia. J Neuropathol Exp Neurol 2010;69:1-15.
52. Popovich PG, Guan Z, McGaughy V, Fisher L, Hickey WF, Basso DM. The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation. J Neuropathol Exp Neurol 2002;61:623-633.
53. Glushakova OY, Johnson D, Hayes RL. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. J Neurotrauma 2014;8:8.
54. Wang LW, Tu YF, Huang CC, Ho CJ. JNK signaling is the shared pathway linking neuroinflammation, blood-brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain. J Neuroinflammation 2012;9:1742-2094.