Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from 2 receptor affinity in mixed P-gp/σ2 receptor agents

European Journal of Medicinal Chemistry

Volumn 89, Issue , 2015, Pages 691-700

  Pati, Maria Laura ^a   Abate, Carmen ^a   Contino, Marialessandra ^a   Ferorelli, Savina ^a   Luisi, Renzo ^a   Carroccia, Laura ^a   Niso, Mauro ^a   Berardi, Francesco ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

67 Dimethoxytetrahydroisoquinoline; Conformational analysis; P glycoprotein; 2 receptor

Indexed keywords

6,7-DIMETHOXYTETRAHYDROISOQUINOLINE; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BINDING; SIGMA OPIATE RECEPTOR; SIGMA-2 RECEPTOR; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOG; DRUG EFFECTS; METABOLISM;

ANIMALS; CELLS, CULTURED; DOGS; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; PROTEIN BINDING; RECEPTORS, SIGMA; TETRAHYDROISOQUINOLINES;

EID: 84908676199     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.11.001     Document Type: Article

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