Arylamides hybrids of two high-affinity σ 2 receptor ligands as tools for the development of PET radiotracers

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4733-4741

  Abate, Carmen ^a   Ferorelli, Savina ^a   Contino, Marialessandra ^a   Marottoli, Roberta ^a   Colabufo, Nicola Antonio ^a   Perrone, Roberto ^a   Berardi, Francesco ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

2 Receptor; 6,7 Dimethoxytetrahydroisoquinoline; Cyclohexylpiperazine; Dihydroisoquinolinone; P Glycoprotein; PET

Indexed keywords

1 CYCLOHEXYL 4 [3 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)PROPYL]PIPERAZIN; 2 [3 [6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]PROPYL] 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; 2 METHOXY 5 METHYL N [4 (6,7 DIMETHOXY 3,4 DIHYDRO 1H ISOQUINOLIN 2 YL)BUTYL]BENZAMIDE; 6,7 DIMETHOXYTETRAHYDROISOQUINOLINE; AROMATIC AMIDE; BENZAMIDE DERIVATIVE; GLYCOPROTEIN P; HYDROGEN; N [3 [6,7 D IMETHOXY-3,4 DIHYDROISOQUINOLIN 2(1H) YL]PROPYL] 2 BROMO 4,5 DIMETHOXYBENZAMIDE; N [3 [6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]PROPYL] 2 METHOXY 5 METHYLBENZAMIDE; N [3 [6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]PROPYL] 5 BROMO 2,3 DIMETHOXYBENZAMIDE; QUINOLONE DERIVATIVE; SIGMA RECEPTOR LIGAND; TRACER; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; GENE OVEREXPRESSION; HYDROGEN BOND; HYPOTHESIS; LIPOPHILICITY; POSITRON EMISSION TOMOGRAPHY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ACRYLAMIDES; ANIMALS; CELL LINE; DOGS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RECEPTORS, SIGMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052946854     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.057     Document Type: Article

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