Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats

Journal of Molecular and Cellular Cardiology

Volumn 77, Issue , 2014, Pages 136-146

  Escobales, Nelson ^a   Nuñez, Rebeca E ^a   Jang, Sehwan ^a   Parodi Rullan, Rebecca ^a   Ayala Peña, Sylvette ^a   Sacher, Joshua R ^c   Skoda, Erin M ^c   Wipf, Peter ^c   Frontera, Walter ^a,b   Javadov, Sabzali ^a  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Aging; Heart; Ischemia reperfusion; Mitochondria; ROS scavenger; XJB 5 131

Indexed keywords

CALCIUM ION; CITRATE SYNTHASE; GRAMICIDIN S; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN SPECIES SCAVENGER; SCAVENGER; UNCLASSIFIED DRUG; XJB 5 131; AMINE OXIDE; CARDIOTONIC AGENT; CARRIER PROTEIN; XJB-5-131;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CARDIOVASCULAR PARAMETERS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; EX VIVO STUDY; FISCHER/BROWN NORWAY RAT; HEART DEPOLARIZATION; HEART FUNCTION; HEART LEFT VENTRICLE DEVELOPED PRESSURE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART PROTECTION; ISOLATED HEART; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; RAT; RATE PRESSURE PRODUCT; REPERFUSION INJURY; RESPIRATORY FAILURE; ANIMAL; CELL LINE; CONVALESCENCE; DRUG SCREENING; FISCHER 344 RAT; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MYOCARDIAL ISCHEMIA; OXYGEN CONSUMPTION;

RATTUS;

ANIMALS; CARDIOTONIC AGENTS; CELL LINE; CYCLIC N-OXIDES; DRUG EVALUATION, PRECLINICAL; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL ISCHEMIA; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RATS, INBRED F344; RECOVERY OF FUNCTION;

EID: 84908670174     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.10.009     Document Type: Article

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