Impairment of Fear-Conditioning Responses and Changes of Brain Neurotrophic Factors in Diet-Induced Obese Mice

Journal of Neuroendocrinology

Volumn 24, Issue 8, 2012, Pages 1120-1125

  Yamada Goto, N ^a   Katsuura, G ^a   Ochi, Y ^a   Ebihara, K ^a,b   Kusakabe, T ^a   Hosoda, K ^a   Nakao, K ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Brain neurotrophic factors; Cognition; Fear conditioning test; High fat diet; Obese mouse

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NEUROTROPHIN 3;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; COGNITION; CONDITIONING; CONTROLLED STUDY; FEAR; HIPPOCAMPUS; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TISSUE DISTRIBUTION;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CONDITIONING, CLASSICAL; DIET; FEAR; MALE; MICE; MICE, INBRED C57BL; NERVE GROWTH FACTORS; OBESITY;

EID: 84863578295     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2012.02327.x     Document Type: Article

References (35)

1. Elias MF, Elias PK, Sullivan LM, Wolf PA, D'Agostino RB. Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study. Int J Obes 2003; 27: 260-268.
2. Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP Jr, Yaffe K. Obesity in middle age and future risk of dementia: a 27year longitudinal population based study. BMJ 2005; 330: 1360-1364.
3. Yamada N, Katsuura G, Ebihara K, Kusakabe T, Hosoda K, Nakao K. Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology 2011; 152: 2634-2643.
4. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW. Central nervous system control of food intake and body weight. Nature 2006; 443: 289-295.
5. Molteni R, Barnard RJ, Ying Z, Roberts CK, Gómez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002; 112: 803-814.
6. Neves G, Cooke SF, Bliss TV. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci 2008; 9: 65-75.
7. Gerges NZ, Aleisa AM, Alkadhi KA. Impaired long-term potentiation in obese zucker rats: possible involvement of presynaptic mechanism. Neuroscience 2003; 120: 535-539.
8. Weiskrantz L. Behavioral changes associated with ablations of the amygdaloid complex in monkeys. J Comp Physiol Psychol 1956; 49: 381-391.
9. Fuster JM, Uyeda AA. Reactivity of limbic neurons of the monkey to appetitive and aversive signals. Electroencephalogr Clin Neurophysiol 1971; 30: 281-293.
10. Rollins B, King BM. Amygdala-lesion obesity: what is the role of the various amygdaloid nuclei? Am J Physiol Regul Integr Comp Physiol 2000; 279: R1348-R1356.
11. King BM. Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus. Am J Physiol Regul Integr Comp Physiol 2006; 291: R1201-R1214.
12. Boghossian S, Park M, York DA. Melanocortin activity in the amygdala controls appetite for dietary fat. Am J Physiol Regul Integr Comp Physiol 2010; 298: R385-R393.
13. Burns ME, Augustine GJ. Synaptic structure and function: dynamic organization yields architectural precision. Cell 1995; 83: 187-194.
14. Poo MM. Neurotrophins as a synaptic modulator. Nat Rev Neurosci 2001; 2: 24-32.
15. Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci USA 1995; 92: 8856-8860.
16. Barbacid M. The Trk family of neurotrophin receptors. J Neurobiol 1994; 25: 1386-1403.
17. Patapoutrian A, Reichardt LF. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 2001; 11: 272-280.
18. Tonra JR, Ono M, Liu X, Garcia K, Jackson C, Yancopoulos GD, Wiegand SJ, Wong V. Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. Diabetes 1999; 48: 588-594.
19. Nakagawa T, Ogawa Y, Ebihara K, Yamanaka M, Tsuchida A, Taiji M, Noguchi H, Nakao K. Anti-obesity and anti-diabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance. Int J Obes Relat Metab Disord 2003; 27: 557-565.
20. Musumeci G, Minichiello L. BDNF-TrkB signalling in fear learning: from genetics to neural networks. Rev Neurosci 2011; 22: 303-315.
21. Malcangio M, Lessmann V. A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors. Trends Pharmacol Sci 2003; 24: 116-1121.
22. McAllister AK, Katz LC, Lo DC. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendrite growth. Neuron 1997; 18: 767-778.
23. Adamson CL, Reid MA, Davis RL. Opposite actions of brain-derived neurotrophic factor and neurotrophin-3 on firing features and ion channel composition of murine spiral ganglion neurons. J Neurosci 2002; 22: 1385-1396.
24. Smith MA, Makino S, Kvetnansky R, Post RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995; 15: 1768-1777.
25. Kim JJ, Jung MW. Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. Neurosci Biobehav Rev 2006; 30: 188-202.
26. Weeber EJ, Atkins CM, Selcher JC, Varga AW, Mirnikjoo B, Paylor R, Leitges M, Sweatt JD. A role for the β isoform of protein kinase C in fear conditioning. J Neurosci 2000; 20: 5906-5914.
27. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Fujimiya M, Katsuura G, Makino S, Fujino MA, Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 2001; 74: 143-147.
28. Kaplan RJ, Greenwood CE. Dietary saturated fatty acids and brain function. Neurochem Res 1998; 23: 615-626.
29. Greenwood CE, Winocur G. Learning and memory impairment in rats fed a high saturated fat diet. Behav Neural Biol 1990; 53: 74-87.
30. Lindqvist A, Mohapel P, Bouter B, Frielingsdorf H, Pizzo D, Brundin P, Erlanson-Albertsson C. High-fat diet impairs hippocampal neurogenesis in male rats. Eur J Neurol 2006; 13: 1385-1388.
31. Farr SA, Yamada KA, Butterfield DA, Abdul HM, Xu L, Miller NE, Banks WA, Morley JE. Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology 2008; 149: 2628-2636.
32. Wickelgren I. Tracking insulin to the mind. Science 1998; 280: 517-519.
33. Gispen WH, Biessels GJ. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 2000; 23: 542-549.
34. Greenwood CE, Winocur G. High-fat diets, insulin resistance and declining cognitive function. Neurobiol Aging 2005; 265: S42-S45.
35. Myers MG, Cowley MA, Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 2008; 70: 537-556.