18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells

Journal of Ethnopharmacology

Volumn 148, Issue 2, 2013, Pages 647-654

  Fu, Xiao Xing ^a   Du, Li Li ^a   Zhao, Ning ^a   Dong, Qian ^a   Liao, Yu Hua ^a   Du, Yi Mei ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Glycyrrhetinic acid Kv1.3 channels Inflammation Immunomodulation Lymphocytes Traditional Chinese medicine

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; GLYCYRRHETINIC ACID; INTERLEUKIN 10; INTERLEUKIN 2; MESSENGER RNA; POTASSIUM CHANNEL KV1.3;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL PROLIFERATION; CELL VIABILITY; CHO CELL; CONCENTRATION (PARAMETERS); CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG CYTOTOXICITY; DRUG POTENCY; ELISA KIT; FEMALE; GENE EXPRESSION; IMMUNOMODULATION; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STEADY STATE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING; WHOLE CELL;

ANIMALS; CALCIUM; CELL LINE, TUMOR; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; GLYCYRRHETINIC ACID; GLYCYRRHIZA; HUMANS; INTERLEUKIN-2; JURKAT CELLS; KV1.3 POTASSIUM CHANNEL; LYMPHOCYTE ACTIVATION; RNA, MESSENGER; T-LYMPHOCYTES;

GLYCYRRHIZA;

EID: 84879413450     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.05.022     Document Type: Article

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