Calcineurin-independent inhibition of Kv1.3 by FK-506 (tacrolimus): A novel pharmacological property

American Journal of Physiology - Cell Physiology

Volumn 292, Issue 5, 2007, Pages

  Hye, Sook Ahn ^a   Sung, Eun Kim ^a   Bok, Hee Choi ^b   Choi, Jin Sung ^a   Kim, Myung Jun ^a   Rhie, Duck Joo ^a   Shin, Hee Yoon ^a   Jo, Yang Hyeok ^a   Kim, Myung Suk ^a   Sung, Ki Wug ^a   Kwon, Oh Joo ^a   Hahn, Sang June ^a  

^a The Catholic University of Korea   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Calcineurin inhibitor; Immunosuppressant; Potassium channel

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; CIPERMETHRIN; PHOSPHATASE; POTASSIUM CHANNEL KV1.3; RAPAMYCIN; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.5; PYRETHROID; SHAL POTASSIUM CHANNEL;

AMPLITUDE MODULATION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONDUCTANCE; CONTROLLED STUDY; DATA ANALYSIS; DEPOLARIZATION; DISSOCIATION CONSTANT; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; FEMALE; HYPERPOLARIZATION; IC 50; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; STEADY STATE; WHOLE CELL; ANIMAL; CELL MEMBRANE POTENTIAL; CHO CELL; CRICETULUS; DOSE RESPONSE; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HAMSTER; KINETICS; METABOLISM;

CRICETULUS GRISEUS;

ANIMALS; CALCINEURIN; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOSUPPRESSIVE AGENTS; KINETICS; KV1.3 POTASSIUM CHANNEL; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PYRETHRINS; SHAL POTASSIUM CHANNELS; SIROLIMUS; TACROLIMUS; TRANSFECTION;

EID: 34250669604     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00258.2006     Document Type: Article

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