Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in Vitro and in Vivo

Neurochemical Research

Volumn 37, Issue 7, 2012, Pages 1560-1567

  Ha, Sang Keun ^a,b   Moon, Eunjung ^a   Lee, Pyeongjae ^c   Ryu, Jong Hoon ^a   Oh, Myung Sook ^a   Kim, Sun Yeou ^a  

^a Kyung Hee University   (South Korea)

^b Korea Food Research Institute   (South Korea)

^c Semyung University   (South Korea)

Author keywords

Acacetin; Microglia; Neuroinflammation; Neuroprotection Ischemia

Indexed keywords

ACACETIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL ACTIVATION; CONTROLLED STUDY; DRUG MECHANISM; GLIA CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NITRIC OXIDE RELEASE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; ROBINIA; ROBINIA PSEUDOACACIA; SECRETION;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; FLAVONES; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; NERVOUS SYSTEM; NEUROPROTECTIVE AGENTS;

ANIMALIA; ROBINIA PSEUDOACACIA;

EID: 84862837855     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0751-z     Document Type: Article

References (25)

1. Ha SK, Lee P, Park JA, Oh HR, Lee SY, Park JH, Lee EH, Ryu JH, Lee KR, Kim SY (2008) Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. Neurochem Int 52(4-5):878-886
2. Ha SK, Moon E, Kim SY (2010) Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-jB and JNK activations in microglia cells. Neurosci Lett 485(3):143-147
3. Lee H, Kim YO, Kim H, Kim SY, Noh HS, Kang SS, Cho GJ, Choi WS, Suk K (2003) Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J 17(13):1943-1944
4. Cody V (1988) Crystal and molecular structures of flavonoids. Prog Clin Biol Res 280:29-44
5. Pan MH, Lai CS, Wang YJ, Ho CT (2006) Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem Pharmacol 72(10):1293-1303
6. Liao YH, Houghton PJ, Hoult JR (1999) Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod 62(9):1241-1245
7. Kraft C, Jenett-Siems K, Siems K, Jakupovic J, Mavi S, Bienzle U, Eich E (2003) In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytother Res 17(2):123-128
8. Singh RP, Agrawal P, Yim D, Agarwal C, Agarwal R (2005) Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structureactivity relationship with linarin and linarin acetate. Carcinogenesis 26(4):845-854
9. Block ML, Hong JS (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76(2):77-98
10. Perry VH, Gordon S (1988) Macrophages and microglia in the nervous system. Trends Neurosci 11(6):273-277
11. Hanisch UK (2002) Microglia as a source and target of cytokines. Glia 40(2):140-155
12. Minghetti L, Levi G (1998) Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 54(1):99-125
13. Gonzalez-Scarano F, Baltuch G (1999) Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 22: 219-240
14. Tak PP, Firestein GS (2001) NF-jB: a key role in inflammatory diseases. J Clin Invest 107(1):7-11
15. Schieven GL (2005) The biology of p38 kinase: a central role in inflammation. Curr Top Med Chem 5(10):921-928
16. Waetzig V, Czeloth K, Hidding U, Mielke K, Kanzow M, Brecht S, Goetz M, Lucius R, Herdegen T, Hanisch UK (2005) c-Jun Nterminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia 50(3):235-246
17. Park JS, Woo MS, Kim SY, Kim WK, Kim HS (2005) Repression of interferon-gamma-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways. J Neuroimmunol 168(1-2):56-64
18. Blasi E, Barluzzi R, Bocchini V, Mozzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying carrying retrovirus. J Neuroimmunol 27(2-3):229-237
19. Cho KO, Kim SK, Cho YJ, Sung KW, Kim SY (2007) Regional differences in the neuroprotective effect of minocycline in a mouse model of global forebrain ischemia. Life Sci 80(22): 2030-2035
20. Fernandez AP, Pozo-Rodrigalvarez A, Serrano J, Martinez-Murillo R (2010) Nitric oxide: target for therapeutic strategies in Alzheimer's disease. Curr Pharm Des 16(25):2837-2850
21. Aquilano K, Baldelli S, Rotilio G, Ciriolo MR (2008) Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res 33(12):2416-2426
22. Parmentier S, Bohme GA, Lerouet D, Damour D, Stutzmann JM, Margaill I, Plotkine M (1999) Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br J Pharmacol 127(2):546-552
23. Giovannini MG, Scali C, Prosperi C, Bellucci A, Pepeu G, Casamenti F (2003) Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors. Int J Immunopathol Pharmacol 16(2 SUPPL.):31-40
24. Barone FC, Feuerstein GZ (1999) Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab 19(8):819-834
25. Samson Y, Lapergue B, Hosseini H (2005) Inflammation and ischaemic stroke: current status and future perspectives. Rev Neurol (Paris) 161(12 Pt 1):1177-1182