IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation

Journal of Clinical Investigation

Volumn 124, Issue 11, 2014, Pages 4709-4722

  Garcia, Maria Noé ^a   Grasso, Daniel ^a   Lopez Millan, Maria Belen ^a   Hamidi, Tewfik ^a   Loncle, Celine ^a   Tomasini, Richard ^a   Lomberk, Gwen ^b   Porteu, Françoise ^c   Urrutia, Raul ^b   Iovanna, Juan L ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b MAYO CLINIC   (United States)

^c Universite Paris Sud   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMEDIATE EARLY RESPONSE 3 PROTEIN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG; IEX-1 PROTEIN, MOUSE; IMMEDIATE EARLY PROTEIN; KRAS2 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN P21;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; EARLY RESPONSE GENE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS ADENOMA; PANCREATIC CANCER CELL LINE; PANCREATITIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; CANCER TRANSPLANTATION; CARCINOMA IN SITU; GENETICS; MALE; METABOLISM; MISSENSE MUTATION; NUDE MOUSE; PANCREAS; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; CARCINOGENESIS; CARCINOMA IN SITU; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMMEDIATE-EARLY PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MICE, NUDE; MICE, TRANSGENIC; MUTATION, MISSENSE; NEOPLASM TRANSPLANTATION; PANCREAS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 84908609029     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76037     Document Type: Article

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