Immunotherapeutic vitamin e nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response

Journal of Controlled Release

Volumn 196, Issue , 2014, Pages 295-306

  Pawar, Vivek K ^a   Panchal, Samir B ^a   Singh, Yuvraj ^a   Meher, Jaya Gopal ^a   Sharma, Komal ^a   Singh, Pankaj ^a   Bora, Himangshu K ^a   Singh, Akhilesh ^a   Datta, Dipak ^a   Chourasia, Manish K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Apoptosis; Cell cycle arrest; Cytokine; Cytotoxicity; Taxol

Indexed keywords

CELL CULTURE; CELL DEATH; CYTOTOXICITY; DISEASES; DRUG PRODUCTS; IMMUNE SYSTEM; MITOCHONDRIA;

ANTI-PROLIFERATIVE ACTIVITIES; CELL-CYCLE ARREST; CYTOKINES; ENCAPSULATION EFFICIENCY; HIGH PRESSURE HOMOGENIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; PHARMACOKINETIC PROFILES; TAXOL;

DRUG DELIVERY;

ALPHA TOCOPHEROL; DRUG CARRIER; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; PACLITAXEL; ANTINEOPLASTIC AGENT; ANTIOXIDANT; EMULSION; NANOPARTICLE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; ELIMINATION HALF-LIFE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; G1 PHASE CELL CYCLE CHECKPOINT; IMMUNE RESPONSE; IMMUNOTHERAPY; IN VITRO STUDY; KIDNEY PARENCHYMA; KIDNEY TUBULE NECROSIS; MALE; MEAN RESIDENCE TIME; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NANOEMULSION; NANOENCAPSULATION; NONHUMAN; PHOTON CORRELATION SPECTROSCOPY; PROTEIN SECRETION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SUSTAINED DRUG RELEASE; TH1 CELL; TH2 CELL; TUMOR VOLUME; WESTERN BLOTTING; ZETA POTENTIAL; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG EFFECTS; EMULSION; HEMOLYSIS; HUMAN; IMMUNOLOGY; MACROPHAGE; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG COMPOUNDING; EMULSIONS; FEMALE; HEMOLYSIS; HUMANS; MACROPHAGES; MICE; MICE, INBRED BALB C; NANOPARTICLES; PACLITAXEL; RATS; RATS, WISTAR; TH1 CELLS; TH2 CELLS; VITAMIN E;

EID: 84908563578     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.10.010     Document Type: Article

References (38)

1. F. Kamangar, G.M. Dores, and W.F. Anderson Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world J. Clin. Oncol. 24 2006 2137 2150
2. M.C. Wani, H.L. Taylor, M.E. Wall, P. Coggon, and A.T. McPhail Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia J. Am. Chem. Soc. 93 1971 2325 2327
3. A. Seidman, A. Tiersten, C. Hudis, M. Gollub, S. Barrett, T. Yao, J. Lepore, T. Gilewski, V. Currie, and J. Crown Phase II trial of paclitaxel by 3-hour infusion as initial and salvage chemotherapy for metastatic breast cancer J. Clin. Oncol. 13 1995 2575 2581
4. H. Gelderblom, J. Verweij, K. Nooter, and A. Sparreboom Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation Eur. J. Cancer 37 2001 1590 1598
5. N. Onetto, R. Canetta, B. Winograd, R. Catane, M. Dougan, J. Grechko, J. Burroughs, and M. Rozencweig Overview of Taxol safety J. Natl. Cancer Inst. Monogr. 1993 131 139
6. H. Pool, S. Mendoza, H. Xiao, and D.J. McClements Encapsulation and release of hydrophobic bioactive components in nanoemulsion-based delivery systems: impact of physical form on quercetin bioaccessibility Food Funct. 4 2013 162 174
7. H. Gaoe, Z. Pang, S. Pan, S. Cao, Z. Yang, C. Chen, and X. Jiang Anti-glioma effect and safety of docetaxel-loaded nanoemulsion Arch. Pharm. Res. 35 2012 333 341
8. S. Asthana, A.K. Jaiswal, P.K. Gupta, V.K. Pawar, A. Dube, and M.K. Chourasia Immunoadjuvant chemotherapy of visceral leishmaniasis in hamsters using amphotericin B-encapsulated nanoemulsion template-based chitosan nanocapsules Antimicrob. Agents Chemother. 57 2013 1714 1722
9. J.-B. Tagne, S. Kakumanu, D. Ortiz, T. Shea, and R.J. Nicolosi A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line Mol. Pharm. 5 2008 280 286
10. S. Ganta, M. Talekar, A. Singh, T. Coleman, and M. Amiji Nanoemulsions in translational research - opportunities and challenges in targeted cancer therapy AAPS PharmSciTech 2014 1 15
11. A.K. Iyer, G. Khaled, J. Fang, and H. Maeda Exploiting the enhanced permeability and retention effect for tumor targeting Drug Discov. Today 11 2006 812 818
12. A.H. Saberi, Y. Fang, and D.J. McClements Fabrication of vitamin E-enriched nanoemulsions: factors affecting particle size using spontaneous emulsification J. Colloid Interface Sci. 391 2013 95 102
13. A.H. Saberi, Y. Fang, and D.J. McClements Stabilization of vitamin E-enriched nanoemulsions: influence of post-homogenization cosurfactant addition J. Agric. Food Chem. 62 2014 1625 1633
14. O.S. El Kinawy, S. Petersen, and J. Ulrich Technological aspects of nanoemulsion formation of low-fat foods enriched with vitamin E by high-pressure homogenization Chem. Eng. Technol. 35 2012 937 940
15. Y. Wang, D. Huang, and R. Watson Vitamin E supplementation modulates cytokine production by thymocytes during murine AIDS Immunol. Res. 12 1993 358 366
16. S.N. Han, D. Wu, W.K. Ha, A. Beharka, D.E. Smith, B.S. Bender, and S.N. Meydani Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus Immunology 100 2000 487 493
17. K.C. Jeng, C.S. Yang, W.Y. Siu, Y.S. Tsai, W.J. Liao, and J.S. Kuo Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults Am. J. Clin. Nutr. 64 1996 960 965
18. S. Romagnani The Th1/Th2 paradigm Immunol. Today 18 1997 263 266
19. T.-T. Tan, and L.M. Coussens Humoral immunity, inflammation and cancer Curr. Opin. Immunol. 19 2007 209 216
20. S. Ostrand-Rosenberg, M.J. Grusby, and V.K. Clements Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma J. Immunol. 165 2000 6015 6019
21. V.K. Pawar, S. Asthana, N. Mishra, M. Chaurasia, and M.K. Chourasia Chitosan coated hydroxypropyl methylcellulose-ethylcellulose shell based gastroretentive dual working system to improve the bioavailability of norfloxacin RSC Adv. 3 2013 19144 19153
22. S. Cheon Lee, C. Kim, I. Chan Kwon, H. Chung, and S. Young Jeong Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly(epsilon-caprolactone) copolymer as a carrier for paclitaxel J. Control. Release 89 2003 437 446
23. R. Dhankar, P. Rathee, A.K. Jain, S. Arora, M.S. Kumar, G. Rath, A.K. Saxena, P. Sharma, G. Chashoo, and A.K. Goyal HER-2 targeted immunonanoparticles for breast cancer chemotherapy J. Appl. Pharm. Sci. 1 2011 132 139
24. J. Ciccolini, J. Catalin, M.F. Blachon, and A. Durand Rapid high-performance liquid chromatographic determination of docetaxel (Taxotere) in plasma using liquid-liquid extraction J. Chromatogr. B 759 2001 299 306
25. O. Kutuk, and A. Letai Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells Cell Death Differ. 17 2010 1624 1635
26. A. Cossarizza, M. Baccaranicontri, G. Kalashnikova, and C. Franceschi A new method for the cytofluorometric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1) Biochem. Biophys. Res. Commun. 197 1993 40 45
27. Y. Ma, D. Liu, D. Wang, Y. Wang, Q. Fu, J.K. Fallon, X. Yang, Z. He, and F. Liu Combinational delivery of hydrophobic and hydrophilic anticancer drugs in single nanoemulsions to treat MDR in cancer Mol. Pharm. 11 2014 2623 2630
28. K. Greish Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting S.R. Grobmyer, B.M. Moudgil, Cancer Nanotechnology 2010 Humana Press 25 37
29. T. Lammers, F. Kiessling, W.E. Hennink, and G. Storm Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress J. Control. Release 161 2012 175 187
30. K. Kline, W. Yu, and B.G. Sanders Vitamin E: mechanisms of action as tumor cell growth inhibitors J. Nutr. 131 2001 161S 163S
31. W. Yu, M. SimmonsMenchaca, A. Gapor, B.G. Sanders, and K. Kline Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols Nutr. Cancer 33 1999 26 32
32. W.F. Symmans, M.D. Volm, R.L. Shapiro, A.B. Perkins, A.Y. Kim, S. Demaria, H.T. Yee, H. McMullen, R. Oratz, P. Klein, S.C. Formenti, and F. Muggia Paclitaxel-induced apoptosis and mitotic arrest assessed by serial fine-needle aspiration: implications for early prediction of breast cancer response to neoadjuvant treatment Clin. Cancer Res. 6 2000 4610 4617
33. A. Sunters, S. Fernández de Mattos, M. Stahl, J.J. Brosens, G. Zoumpoulidou, C.A. Saunders, P.J. Coffer, R.H. Medema, R.C. Coombes, and E.W.-F. Lam FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines J. Biol. Chem. 278 2003 49795 49805
34. J. Neuzil Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity Br. J. Cancer 89 2003 1822 1826
35. S.N. Meydani, M. Meydani, C.P. Verdon, A.A. Shapiro, J.B. Blumberg, and K.C. Hayes Vitamin E supplementation suppresses prostaglandin E1(2) synthesis and enhances the immune response of aged mice Mech. Ageing Dev. 34 1986 191 201
36. T.C. van der Pouw Kraan, L.C. Boeije, R.J. Smeenk, J. Wijdenes, and L.A. Aarden Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production J. Exp. Med. 181 1995 775 779
37. V. Shreedhar, T. Giese, V.W. Sung, and S.E. Ullrich A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression J. Immunol. 160 1998 3783 3789
38. Y. Huang, Y. Lei, H. Zhang, M. Zhang, and A. Dayton Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells J. Leukoc. Biol. 90 2011 87 97