Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells

Journal of Leukocyte Biology

Volumn 90, Issue 1, 2011, Pages 87-97

  Huang, Yong ^a   Lei, Ying Feng ^a   Zhang, Hai ^a   Zhang, Mingjie ^a,b   Dayton, Andrew ^a,b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

Author keywords

Negative feedback mechanism; Transcription factors

Indexed keywords

CASPASE 3; CYTOCHROME C; GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; STAT4 PROTEIN;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CYTOKINE PRODUCTION; DOWN REGULATION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BLOTTING, WESTERN; CELL SEPARATION; DOWN-REGULATION; FEEDBACK, PHYSIOLOGICAL; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-12; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR;

EID: 79959847867     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1210674     Document Type: Article

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