Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys

Synapse

Volumn 68, Issue 11, 2014, Pages 556-564

  Gallezot, Jean Dominique ^a   Esterlis, Irina ^b   Bois, Frederic ^b   Zheng, Ming Qiang ^a   Lin, Shu Fei ^a   Kloczynski, Tracy ^b   Krystal, John H ^b   Huang, Yiyun ^a   Sabri, Osama ^c   Carson, Richard E ^a   Cosgrove, Kelly P ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

18F ( ) Flubatine; 18F ( ) NCFHEB; Acetylcholine; Brain; Donepezil; Nicotinic acetylcholine receptors; Physostigmine; Rhesus monkeys

Indexed keywords

ACETYLCHOLINE; CHOLINESTERASE INHIBITOR; DONEPEZIL; FLUBATINE F 18; NICOTINIC RECEPTOR ALPHA4BETA2; PHYSOSTIGMINE; TRACER; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; FLUORONORCHLOROEPIBATIDINE; FUSED HETEROCYCLIC RINGS; NICOTINIC RECEPTOR; PROTEIN BINDING; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; BREATHING RATE; CEREBELLUM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; POSITRON EMISSION TOMOGRAPHY; PRE-CLINICAL IMAGING DEVICE; PUTAMEN; RHESUS MONKEY; SYNAPSE; THALAMUS; VOLUME OF DISTRIBUTION; ANIMAL; BRAIN; EVALUATION STUDY; METABOLISM; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

ACETYLCHOLINE; ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; MACACA MULATTA; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; RECEPTORS, NICOTINIC; SENSITIVITY AND SPECIFICITY; SYNAPSES; TISSUE DISTRIBUTION;

EID: 84908499128     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21767     Document Type: Article

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