PET imaging of acetylcholinesterase inhibitor-induced effects on α4β2 nicotinic acetylcholine receptor binding

Synapse

Volumn 67, Issue 12, 2013, Pages 882-886

  Hillmer, Ansel T ^a,b   Wooten, Dustin W ^a,b   Farhoud, Mohammed ^c   Higgins, Andrew T ^b   Lao, Patrick J ^a,b   Barnhart, Todd E ^a   Mukherjee, Jogeshwar ^d   Christian, Bradley T ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

18F nifene; Acetylcholinesterase inhibitors; Galanthamine; Nicotinic acetylcholine receptor; PET; Physostigmine

Indexed keywords

GALANTAMINE; NEUROTRANSMITTER; NICOTINIC RECEPTOR ALPHA4BETA2; NIFINE F 18; PHYSOSTIGMINE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; DRUG UPTAKE; FEMALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

ACETYLCHOLINESTERASE INHIBITORS; GALANTHAMINE; NICOTINIC ACETYLCHOLINE RECEPTOR; PET; PHYSOSTIGMINE; [18F]NIFENE;

ANIMALS; BRAIN; CHOLINESTERASE INHIBITORS; FEMALE; GALANTAMINE; PHYSOSTIGMINE; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC;

EID: 84885862628     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21698     Document Type: Article

References (20)

1. Alpert NM, Badgaiyan RD, Livni E, Fischman AJ. 2003. A novel method for noninvasive detection of neuromodulatory changes in specific neurotransmitter systems. Neuroimage 19:1049-1060.
2. Bartus RT, Dean RL, Beer B, Lippa AS. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-417.
3. 11C]raclopride binding with continuous infusion. J Cereb Blood Flow Metab 17:437-447.
4. Christian BT, Vandehey NT, Floberg JM, Mistretta CA. 2010. Dynamic PET denoising with HYPR processing. J Nucl Med 51:1147-1154.
5. Constantinescu CC, Mukherjee J. 2009. Performance evaluation of an Inveon PET preclinical scanner. Phys Med Biol 54:2885-2899.
6. 18F-nifene: A measure of acetylcholine competition. Synapse 36:29-36.
7. Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. 2013. Imaging changes in synaptic acetylcholine availability in living human subjects. J Nucl Med 54:78-82.
8. 123I]5-I-A-85380. Synapse 48:116-122.
9. 18F-nifene kinetics in the nonhuman primate. J Nucl Med 53:1471-1480.
10. 18F]nifene in rats. J Neurosci Methods 214:163-169.
11. Hogg RC, Raggenbass M, Bertrand D. 2003. Nicotinic acetylcholine receptors: From structure to brain function. Rev Physiol Biochem Pharmacol 147:1-46.
12. 11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23:1096-1112.
13. Jackisch R, Förster S, Kammerer M, Rothmaier AK, Ehret A, Zentner J, Feuerstein TJ. 2009. Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex. J Alzheimers Dis 16:635-647.
14. Kaduszkiewicz H, Zimmerman T, Beck-Bornholdt H-P, van den Bussche H. 2005. Cholinesterase inhibitors for patients with Alzheimer's disease: Systematic review of randomised clinical trials. BMJ 331:321-327.
15. Mannens GSJ, Snel CAW, Hendrickx J, Verhaeghe T, le Jeune L, Bode W, van Beijsterveldt L, Lavrijsen K, Leempoels J, van Osselaer N, van Peer A, Meuldermans W. 2002. The metabolism and excretion of galantamine in rats, dogs, and humans. Drug Metab Dispos 30:553-563.
16. Morris ED, Yoder KK. 2007. Positron emission tomography displacement sensitivity: Predicting binding potential change for positron emission tomography tracers based on their kinetic characteristics. J Cereb Blood Flow Metab 27:606-617.
17. Morris ED, Yoder KK, Wang C, Normandin MD, Zheng Q-H, Mock B, Muzic RF, Froehlich JC. 2005. ntPET: A new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release. Mol Imaging 4:473-489.
18. Normandin MD, Schiffer WK, Morris ED. 2012. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. NeuroImage 59:2689-2699.
19. Paxinos G, Watson C. 1998. The rat brain in sterotaxic coordinates, 4th ed. San Diego: Academic Press.
20. 18F]Fluoro-A-85380: A PET study in monkeys. Synapse 56:217-221.