SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 2, 2014, Pages 804-812

Synthesis and biological evaluation of both enantiomers of [ 18F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors

(11) Smits, René a Fischer, Steffen b Hiller, Achim b Deuther Conrad, Winnie b Wenzel, Barbara b Patt, Marianne c Cumming, Paul a Steinbach, Jörg b Sabri, Osama c Brust, Peter b Hoepping, Alexander a

a ABX Advanced Biochemical Compounds GmbH (Germany)

b INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH (Germany)

c UNIVERSITY OF LEIPZIG (Germany)

Author keywords

Alzheimers's disease (AD); Flubatine; Fluorine 18; Nicotinic acetylcholine receptor (nAChR); PET

Indexed keywords

FLUBATINE F 18; NICOTINIC RECEPTOR ALPHA4BETA2; TRACER; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; FLUORINE; FLUORONORCHLOROEPIBATIDINE; FUSED HETEROCYCLIC RINGS; NICOTINIC RECEPTOR; RADIOPHARMACEUTICAL AGENT;

AFFINITY LABELING; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; FEMALE; HUMAN; IN VITRO STUDY; ISOTOPE LABELING; MALE; MOLECULAR IMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN INTERACTION; RADIOACTIVITY; RADIOSENSITIVITY; RAT; ANIMAL; BRAIN; CHEMISTRY; DIAGNOSTIC USE; KINETICS; METABOLISM; SCINTISCANNING; STEREOISOMERISM; SWINE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

RODENTIA;

ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CRYSTALLOGRAPHY, X-RAY; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; KINETICS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RADIOPHARMACEUTICALS; RATS; RECEPTORS, NICOTINIC; STEREOISOMERISM; SWINE;

EID: 84892374228 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.12.011 Document Type: Article

Times cited : (27)

References (44)

1
- 84858591462
- A.D. Joshi, M.J. Pontecorvo, C.M. Clark, A.P. Carpenter, D.L. Jennings, C.H. Sadowsky, L.P. Adler, K.D. Kovnat, J.P. Seibyl, A. Arora, K. Saha, J.D. Burns, M.J. Lowrey, M.A. Mintun, and D.M. Skovronsky J. Nucl. Med. 53 2012 378
- (2012) J. Nucl. Med. , vol.53 , pp. 378
- Joshi, A.D.¹ Pontecorvo, M.J.² Clark, C.M.³ Carpenter, A.P.⁴ Jennings, D.L.⁵ Sadowsky, C.H.⁶ Adler, L.P.⁷ Kovnat, K.D.⁸ Seibyl, J.P.⁹ Arora, A.¹⁰ Saha, K.¹¹ Burns, J.D.¹² Lowrey, M.J.¹³ Mintun, M.A.¹⁴ Skovronsky, D.M.¹⁵

2
- 79958792912
- K. Herholz, and K. Ebmeier Lancet Neurol. 10 2011 667
- (2011) Lancet Neurol. , vol.10 , pp. 667
- Herholz, K.¹ Ebmeier, K.²

3
- 79955662958
- A. Kurz, and R. Perneczky J. Alzheimers Dis. 24 2011 61
- (2011) J. Alzheimers Dis. , vol.24 , pp. 61
- Kurz, A.¹ Perneczky, R.²

4
- 79955629703
- S. Graef, P. Schönknecht, O. Sabri, and U. Hegerl Psychopharmacology (Berlin, Ger.) 215 2011 205
- (2011) Psychopharmacology (Berlin, Ger.) , vol.215 , pp. 205
- Graef, S.¹ Schönknecht, P.² Sabri, O.³ Hegerl, U.⁴

5
- 0029133310
- J. Lindstrom, R. Anand, X. Peng, V. Gerzanich, F. Wang, and Y. Li Ann. N.Y. Acad. Sci. 757 1995 100
- (1995) Ann. N.Y. Acad. Sci. , vol.757 , pp. 100
- Lindstrom, J.¹ Anand, R.² Peng, X.³ Gerzanich, V.⁴ Wang, F.⁵ Li, Y.⁶

6
- 80052031263
- C.G. Baddick, and M.J. Marks Biochem. Pharmacol. 82 2011 828
- (2011) Biochem. Pharmacol. , vol.82 , pp. 828
- Baddick, C.G.¹ Marks, M.J.²

7
- 0034885744
- E.K. Perry, C.M. Martin-Ruiz, and J.A. Court Alcohol 24 2001 63
- (2001) Alcohol , vol.24 , pp. 63
- Perry, E.K.¹ Martin-Ruiz, C.M.² Court, J.A.³

8
- 19244378105
- E. Perry, C. Martin-Ruiz, M. Lee, M. Griffiths, M. Johnson, M. Piggott, V. Haroutunian, J.D. Buxbaum, J. Nasland, K. Davis, C. Gotti, F. Clementi, S. Tzartos, O. Cohen, H. Soreq, E. Jaros, R. Perry, C. Ballard, I. McKeith, and J. Court Eur. J. Pharmacol. 393 2000 215
- (2000) Eur. J. Pharmacol. , vol.393 , pp. 215
- Perry, E.¹ Martin-Ruiz, C.² Lee, M.³ Griffiths, M.⁴ Johnson, M.⁵ Piggott, M.⁶ Haroutunian, V.⁷ Buxbaum, J.D.⁸ Nasland, J.⁹ Davis, K.¹⁰ Gotti, C.¹¹ Clementi, F.¹² Tzartos, S.¹³ Cohen, O.¹⁴ Soreq, H.¹⁵ Jaros, E.¹⁶ Perry, R.¹⁷ Ballard, C.¹⁸ McKeith, I.¹⁹ Court, J.²⁰ more..

9
- 33847250946
- A. Kadir, O. Almkvist, A. Wall, B. Langström, and A. Nordberg Psychopharmacology (Berlin, Ger.) 188 2006 509
- (2006) Psychopharmacology (Berlin, Ger.) , vol.188 , pp. 509
- Kadir, A.¹ Almkvist, O.² Wall, A.³ Langström, B.⁴ Nordberg, A.⁵

10
- 33947721287
- J.T. O'Brien, S.J. Colloby, S. Pakrasi, E.K. Perry, S.L. Pimlott, D.J. Wyper, I.G. McKeith, and E.D. Williams J. Neurol. Neurosurg. Psychiatry 78 2007 356
- (2007) J. Neurol. Neurosurg. Psychiatry , vol.78 , pp. 356
- O'Brien, J.T.¹ Colloby, S.J.² Pakrasi, S.³ Perry, E.K.⁴ Pimlott, S.L.⁵ Wyper, D.J.⁶ McKeith, I.G.⁷ Williams, E.D.⁸

11
- 79953765442
- K. Kendziorra, H. Wolf, P.M. Meyer, H. Barthel, S. Hesse, G.A. Becker, J. Luthardt, A. Schildan, M. Patt, D. Sorger, A. Seese, H.J. Gertz, and O. Sabri Eur. J. Nucl. Med. Mol. Imaging 38 2011 515
- (2011) Eur. J. Nucl. Med. Mol. Imaging , vol.38 , pp. 515
- Kendziorra, K.¹ Wolf, H.² Meyer, P.M.³ Barthel, H.⁴ Hesse, S.⁵ Becker, G.A.⁶ Luthardt, J.⁷ Schildan, A.⁸ Patt, M.⁹ Sorger, D.¹⁰ Seese, A.¹¹ Gertz, H.J.¹² Sabri, O.¹³

12
- 34547167527
- H. Valette, F. Dolle, W. Saba, G. Roger, F. Hinnen, C. Coulon, M. Ottaviani, A. Syrota, and M. Bottlaender Synapse 61 2007 764
- (2007) Synapse , vol.61 , pp. 764
- Valette, H.¹ Dolle, F.² Saba, W.³ Roger, G.⁴ Hinnen, F.⁵ Coulon, C.⁶ Ottaviani, M.⁷ Syrota, A.⁸ Bottlaender, M.⁹

13
- 84855400620
- H. Kuwabara, D.F. Wong, Y. Gao, H. Valentine, D.P. Holt, H.T. Ravert, R.F. Dannals, and A.G. Horti J. Nucl. Med. 53 2012 121
- (2012) J. Nucl. Med. , vol.53 , pp. 121
- Kuwabara, H.¹ Wong, D.F.² Gao, Y.³ Valentine, H.⁴ Holt, D.P.⁵ Ravert, H.T.⁶ Dannals, R.F.⁷ Horti, A.G.⁸

14
- 5044235132
- W. Deuther-Conrad, J.T. Patt, D. Feuerbach, F. Wegner, P. Brust, and J. Steinbach Farmaco 59 2004 785
- (2004) Farmaco , vol.59 , pp. 785
- Deuther-Conrad, W.¹ Patt, J.T.² Feuerbach, D.³ Wegner, F.⁴ Brust, P.⁵ Steinbach, J.⁶

15
- 38149021383
- W. Deuther-Conrad, J.T. Patt, P.R. Lockman, D.D. Allen, M. Patt, A. Schildan, V. Ganapathy, J. Steinbach, O. Sabri, and P. Brust Eur. Neuropsychopharmacol. 18 2008 222
- (2008) Eur. Neuropsychopharmacol. , vol.18 , pp. 222
- Deuther-Conrad, W.¹ Patt, J.T.² Lockman, P.R.³ Allen, D.D.⁴ Patt, M.⁵ Schildan, A.⁶ Ganapathy, V.⁷ Steinbach, J.⁸ Sabri, O.⁹ Brust, P.¹⁰

16
- 38749121718
- P. Brust, J.T. Patt, W. Deuther-Conrad, G. Becker, M. Patt, A. Schildan, D. Sorger, K. Kendziorra, P. Meyer, J. Steinbach, and O. Sabri Synapse 62 2008 205
- (2008) Synapse , vol.62 , pp. 205
- Brust, P.¹ Patt, J.T.² Deuther-Conrad, W.³ Becker, G.⁴ Patt, M.⁵ Schildan, A.⁶ Sorger, D.⁷ Kendziorra, K.⁸ Meyer, P.⁹ Steinbach, J.¹⁰ Sabri, O.¹¹

17
- 84887818483
- B.G. Hockley, M.N. Stewart, P. Sherman, C. Quesada, M.R. Kilbourn, R.L. Albin, and P.J.H. Scott J. Labelled Compd. Radiopharm. 56 2013 595
- (2013) J. Labelled Compd. Radiopharm. , vol.56 , pp. 595
- Hockley, B.G.¹ Stewart, M.N.² Sherman, P.³ Quesada, C.⁴ Kilbourn, M.R.⁵ Albin, R.L.⁶ Scott, P.J.H.⁷

18
- 33646037088
- J.T. Patt, W. Deuther-Conrad, K. Wohlfahrt, D. Feuerbach, P. Brust, and J. Steinbach J. Labelled Compd. Radiopharm. 46 2003 S168
- (2003) J. Labelled Compd. Radiopharm. , vol.46 , pp. 168
- Patt, J.T.¹ Deuther-Conrad, W.² Wohlfahrt, K.³ Feuerbach, D.⁴ Brust, P.⁵ Steinbach, J.⁶

19
- 0344298556
- D. Bai, R. Xu, G. Chu, and X. Zhu J. Org. Chem. 61 1996 4600
- (1996) J. Org. Chem. , vol.61 , pp. 4600
- Bai, D.¹ Xu, R.² Chu, G.³ Zhu, X.⁴

20
- 84892365758
- Institute of Interdisciplinary Isotope Research Leipzig Annual Report
- 18F]Fluoro-A-85380 in Mice 2003 Institute of Interdisciplinary Isotope Research Leipzig Annual Report
- (2003) 18F]Fluoro-A-85380 in Mice
- Patt, J.T.¹ Deuther-Conrad, W.² Brust, P.³

21
- 0033937198
- H. Kim, and H.M.R. Hoffmann Eur. J. Org. Chem. 2000 2195
- (2000) Eur. J. Org. Chem. , pp. 2195
- Kim, H.¹ Hoffmann, H.M.R.²

22
- 37049097407
- M.G.B. Drew, A.V. George, and N.S. Isaacs J. Chem. Soc., Perkin Trans. 1 1985 1277
- (1985) J. Chem. Soc., Perkin Trans. 1 , pp. 1277
- Drew, M.G.B.¹ George, A.V.² Isaacs, N.S.³

23
- 37049079670
- J. Mann, and L.-C. de Almeida Barbosa J. Chem. Soc., Perkin Trans. 1 1992 787
- (1992) J. Chem. Soc., Perkin Trans. 1 , pp. 787
- Mann, J.¹ De Almeida Barbosa, L.-C.²

24
- 0242491571
- N. Cramer, S. Laschat, A. Baro, and W. Frey Synlett 2003 2175
- (2003) Synlett , pp. 2175
- Cramer, N.¹ Laschat, S.² Baro, A.³ Frey, W.⁴

25
- 84892364919
- D.M. Hodgson, and E. Paruch Tetrahedron 60 2004 5158
- (2004) Tetrahedron , vol.60 , pp. 5158
- Hodgson, D.M.¹ Paruch, E.²

26
- 37049066674
- R.C. Larock, and P.L. Johnson J. Chem. Soc., Chem. Commun. 1989 1368
- (1989) J. Chem. Soc., Chem. Commun. , pp. 1368
- Larock, R.C.¹ Johnson, P.L.²

27
- 0000626165
- A. Arcadi, F. Marinelli, E. Bernocchi, S. Cacchi, and G. Ortar J. Organomet. Chem. 368 1989 249
- (1989) J. Organomet. Chem. , vol.368 , pp. 249
- Arcadi, A.¹ Marinelli, F.² Bernocchi, E.³ Cacchi, S.⁴ Ortar, G.⁵

28
- 0034616253
- X.-Y. Wu, H.-D. Xu, Q.-L. Zhou, and A.S.C. Chan Tetrahedron: Asymmetry 11 2000 1255
- (2000) Tetrahedron: Asymmetry , vol.11 , pp. 1255
- Wu, X.-Y.¹ Xu, H.-D.² Zhou, Q.-L.³ Chan, A.S.C.⁴

29
- 0035888914
- X.-Y. Wu, H.-D. Xu, F.-Y. Tang, and Q.-L. Zhou Tetrahedron: Asymmetry 12 2001 2565
- (2001) Tetrahedron: Asymmetry , vol.12 , pp. 2565
- Wu, X.-Y.¹ Xu, H.-D.² Tang, F.-Y.³ Zhou, Q.-L.⁴

30
- 0032998103
- J.C. Namyslo, and D.E. Kaufmann Synlett 1999 804
- (1999) Synlett , pp. 804
- Namyslo, J.C.¹ Kaufmann, D.E.²

31
- 0027373899
- S.C. Clayton, and A.C. Regan Tetrahedron Lett. 34 1993 7493
- (1993) Tetrahedron Lett. , vol.34 , pp. 7493
- Clayton, S.C.¹ Regan, A.C.²

32
- 33750236967
- W.A. Herrmann, C. Broßmer, K. Öfele, C.-P. Reisinger, T. Priermeier, M. Beller, and H. Fischer Angew. Chem., Int. Ed. 34 1995 1844
- (1995) Angew. Chem., Int. Ed. , vol.34 , pp. 1844
- Herrmann, W.A.¹ Broßmer, C.² Öfele, K.³ Reisinger, C.-P.⁴ Priermeier, T.⁵ Beller, M.⁶ Fischer, H.⁷

33
- 0033173592
- Y.H. Kim, D.Y. Won, C.Y. Oh, K.Y. Lee, J.H. Jeong, Y.H. Jung, and W.H. Ham Arch. Pharmacol. Res. 22 1999 435
- (1999) Arch. Pharmacol. Res. , vol.22 , pp. 435
- Kim, Y.H.¹ Won, D.Y.² Oh, C.Y.³ Lee, K.Y.⁴ Jeong, J.H.⁵ Jung, Y.H.⁶ Ham, W.H.⁷

34
- 1442317045
- A.J. Moreno-Vargas, and P. Vogel Tetrahedron: Asymmetry 14 2003 3173
- (2003) Tetrahedron: Asymmetry , vol.14 , pp. 3173
- Moreno-Vargas, A.J.¹ Vogel, P.²

35
- 0030759242
- F. Liang, H.A. Navarro, P. Abraham, P. Kotian, Y.-S. Ding, J. Fowler, N. Volkow, M.J. Kuhar, and F.I. Carroll J. Med. Chem. 40 1997 2293
- (1997) J. Med. Chem. , vol.40 , pp. 2293
- Liang, F.¹ Navarro, H.A.² Abraham, P.³ Kotian, P.⁴ Ding, Y.-S.⁵ Fowler, J.⁶ Volkow, N.⁷ Kuhar, M.J.⁸ Carroll, F.I.⁹

36
- 84873934491
- S. Fischer, A. Hiller, R. Smits, A. Hoepping, U. Funke, B. Wenzel, P. Cumming, O. Sabri, J. Steinbach, and P. Brust Appl. Radiat. Isot. 74 2013 128
- (2013) Appl. Radiat. Isot. , vol.74 , pp. 128
- Fischer, S.¹ Hiller, A.² Smits, R.³ Hoepping, A.⁴ Funke, U.⁵ Wenzel, B.⁶ Cumming, P.⁷ Sabri, O.⁸ Steinbach, J.⁹ Brust, P.¹⁰

37
- 84879524982
- M. Patt, A. Schildan, B. Habermann, S. Fischer, A. Hiller, W. Deuther-Conrad, S. Wilke, R. Smits, A. Hoepping, G. Wagenknecht, J. Steinbach, P. Brust, and O. Sabri Appl. Radiat. Isot. 80 2013 7
- (2013) Appl. Radiat. Isot. , vol.80 , pp. 7
- Patt, M.¹ Schildan, A.² Habermann, B.³ Fischer, S.⁴ Hiller, A.⁵ Deuther-Conrad, W.⁶ Wilke, S.⁷ Smits, R.⁸ Hoepping, A.⁹ Wagenknecht, G.¹⁰ Steinbach, J.¹¹ Brust, P.¹² Sabri, O.¹³

38
- 32044438694
- W. Deuther-Conrad, A. Wevers, G. Becker, A. Schildan, M. Patt, O. Sabri, J. Steinbach, and P. Brust Synapse 59 2006 201
- (2006) Synapse , vol.59 , pp. 201
- Deuther-Conrad, W.¹ Wevers, A.² Becker, G.³ Schildan, A.⁴ Patt, M.⁵ Sabri, O.⁶ Steinbach, J.⁷ Brust, P.⁸

39
- 17344392131
- S.J. Gatley, Y.S. Ding, D. Brady, A.N. Gifford, S.L. Dewey, F.I. Carroll, J.S. Fowler, and N.D. Volkow Nucl. Med. Biol. 25 1998 449
- (1998) Nucl. Med. Biol. , vol.25 , pp. 449
- Gatley, S.J.¹ Ding, Y.S.² Brady, D.³ Gifford, A.N.⁴ Dewey, S.L.⁵ Carroll, F.I.⁶ Fowler, J.S.⁷ Volkow, N.D.⁸

40
- 0038249139
- Z.Y. Han, M. Zoli, A. Cardona, J.P. Bourgeois, J.P. Changeux, and N. Le Novere J. Comp. Neurol. 461 2003 49
- (2003) J. Comp. Neurol. , vol.461 , pp. 49
- Han, Z.Y.¹ Zoli, M.² Cardona, A.³ Bourgeois, J.P.⁴ Changeux, J.P.⁵ Le Novere, N.⁶

41
- 0032144468
- W. Sihver, P.G. Gillberg, and A. Nordberg Neuroscience 85 1998 1121
- (1998) Neuroscience , vol.85 , pp. 1121
- Sihver, W.¹ Gillberg, P.G.² Nordberg, A.³

42
- 34347241377
- N. Moser, N. Mechawar, I. Jones, A. Gochberg-Sarver, A. Orr-Urtreger, M. Plomann, R. Salas, B. Molles, L. Marubio, U. Roth, U. Maskos, U. Winzer-Serhan, J.P. Bourgeois, A.M. Le Sourd, M. De Biasi, H. Schröder, J. Lindstrom, A. Maelicke, J.P. Changeux, and A. Wevers J. Neurochem. 102 2007 479
- (2007) J. Neurochem. , vol.102 , pp. 479
- Moser, N.¹ Mechawar, N.² Jones, I.³ Gochberg-Sarver, A.⁴ Orr-Urtreger, A.⁵ Plomann, M.⁶ Salas, R.⁷ Molles, B.⁸ Marubio, L.⁹ Roth, U.¹⁰ Maskos, U.¹¹ Winzer-Serhan, U.¹² Bourgeois, J.P.¹³ Le Sourd, A.M.¹⁴ De Biasi, M.¹⁵ Schröder, H.¹⁶ Lindstrom, J.¹⁷ Maelicke, A.¹⁸ Changeux, J.P.¹⁹ Wevers, A.²⁰ more..

43
- 37549054327
- J.D. Gallezot, M.A. Bottlaender, J. Delforge, H. Valette, W. Saba, F. Dolle, C.M. Coulon, M.P. Ottaviani, F. Hinnen, A. Syrota, and M.C. Gregoire J. Cereb. Blood Flow Metab. 28 2008 172
- (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 172
- Gallezot, J.D.¹ Bottlaender, M.A.² Delforge, J.³ Valette, H.⁴ Saba, W.⁵ Dolle, F.⁶ Coulon, C.M.⁷ Ottaviani, M.P.⁸ Hinnen, F.⁹ Syrota, A.¹⁰ Gregoire, M.C.¹¹

44
- 0346688558
- S.L. Pimlott, M. Piggott, J. Owens, E. Greally, J.A. Court, E. Jaros, R.H. Perry, E.K. Perry, and D. Wyper Neuropsychopharmacology 29 2004 108
- (2004) Neuropsychopharmacology , vol.29 , pp. 108
- Pimlott, S.L.¹ Piggott, M.² Owens, J.³ Greally, E.⁴ Court, J.A.⁵ Jaros, E.⁶ Perry, R.H.⁷ Perry, E.K.⁸ Wyper, D.⁹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.