Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application

Applied Radiation and Isotopes

Volumn 80, Issue , 2013, Pages 7-11

  Patt, Marianne ^a   Schildan, Andreas ^a   Habermann, Bernd ^a   Fischer, Steffen ^b   Hiller, Achim ^b   Deuther Conrad, Winnie ^b   Wilke, Stephan ^a   Smits, René ^c   Hoepping, Alexander ^c   Wagenknecht, Gudrun ^d   Steinbach, Jörg ^b   Brust, Peter ^b   Sabri, Osama ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^c ABX Advanced Biochemical Compounds GmbH   (Germany)

^d FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

4 2 Nicotinic acetylcholine receptors; Automation; Flubatine; Fluorine 18; GMP; NCFHEB

Indexed keywords

FLUBATINE; FLUORINE-18; GMP; NCFHEB; NICOTINIC ACETYLCHOLINE RECEPTORS;

AUTOMATION; RADIATION;

ISOTOPES;

FLUBATINE; FLUORINE 18; NORCHLOROFLUOROHOMOEPIBATIDINE; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ANALYTICAL EQUIPMENT; ARTICLE; AUTOANALYSIS; DRUG DETERMINATION; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; GOOD MANUFACTURING PRACTICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; PRIORITY JOURNAL; QUANTUM YIELD; RADIOCHEMISTRY; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS;

Α(4)Β(2) NICOTINIC ACETYLCHOLINE RECEPTORS; AUTOMATION; FLUBATINE; FLUORINE-18; GMP; NCFHEB;

AUTOMATION; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; HUMANS; QUALITY CONTROL; STEREOISOMERISM;

EID: 84879524982     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2013.05.009     Document Type: Article

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