Rat models of asthma and chronic obstructive lung disease

Pulmonary Pharmacology and Therapeutics

Volumn 19, Issue 6, 2006, Pages 377-385

  Martin, James G ^a   Tamaoka, Meiyo ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Adoptive transfer; Anti oxidants; Bromo deoxyuridine; Cysteinyl leukotrienes; Early airway responses; Emphysema; Late airway responses; Proliferating cell nuclear antigen

Indexed keywords

ALLERGEN; CHLORINE; CORTICOSTEROID; CYCLOSPORIN A; DEXAMETHASONE; ELASTASE; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; RETINOIC ACID; SEROTONIN; STEROID; SULFUR DIOXIDE;

ADOPTIVE TRANSFER; AIRWAY; AIRWAY CONSTRICTION; AIRWAY OBSTRUCTION; ANTIINFLAMMATORY ACTIVITY; ASTHMA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DAMAGE; CELL KINETICS; CELLULITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CORRELATION ANALYSIS; DISEASE MODEL; DRUG INHIBITION; DRUG MECHANISM; EMPHYSEMA; EOSINOPHIL; EXERCISE INDUCED ASTHMA; HELPER CELL; HYPERPNEA; IMMUNOASSAY; LUNG PARENCHYMA; LUNG RESISTANCE; MOLECULAR MIMICRY; NONHUMAN; OCCUPATIONAL ALLERGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; RAT STRAIN; RESPIRATORY AIRFLOW; RESPIRATORY TRACT DISEASE; REVIEW; SENSITIZATION; T LYMPHOCYTE ACTIVATION; VIRAL RESPIRATORY TRACT INFECTION;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; DISEASE MODELS, ANIMAL; EMPHYSEMA; HUMANS; PANCREATIC ELASTASE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; SMOKING;

EID: 33747154430     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2005.10.005     Document Type: Review

References (83)

1. Solway J., and Fredberg J.J. Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness after all. Am J Respir Cell Mol Biol 17 2 (1997) 144-146
2. Macklem P.T. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med 153 1 (1996) 83-89
3. Lambrecht B.N. Allergen uptake and presentation by dendritic cells. Curr Opin Allergy Clin Immunol 1 1 (2001) 51-59
4. Pauwels R., van der Straeten M., Weyne J., and Bazin H. Genetic factors in non-specific bronchial reactivity in rats. Eur J Respir Dis 66 (1985) 98-104
5. Martin J.G., Opazo-Saez A., Du T., Tepper R., and Eidelman D.H. In vivo airway reactivity: predictive value of morphological estimates of airway smooth muscle. [Review]. Can J Physiol Pharmacol 70 (1992) 597-601
6. Eidelman D.H., DiMaria G.U., Bellofiore S., Wang N.S., Guttmann R.D., and Martin J.G. Strain-related differences in airway smooth muscle and airway responsiveness in the rat. Am Rev Respir Dis 144 (1991) 792-796
7. Florio C., Styhler A., Heisler S., and Martin J.G. Mechanical responses of tracheal tissue in vitro: dependence on the tissue preparation employed and relationship to smooth muscle content. Pulm Pharmacol 9 3 (1996) 157-166
8. Jia Y., Xu L., Heisler S., and Martin J.G. Airways of a hyperresponsive rat strain show decreased relaxant responses to sodium nitroprusside. Am J Physiol 269 (1995) L85-L91
9. Jia Y., Xu L., Turner D.J., and Martin J.G. Endogenous nitric oxide contributes to strain-related differences in airway responsiveness in rats. J Appl Physiol 80 2 (1996) 404-410
10. Tao F.C., Tolloczko B., Eidelman D.H., and Martin J.G. Enhanced Ca(2+) mobilization in airway smooth muscle contributes to airway hyperresponsiveness in an inbred strain of rat. Am J Respir Crit Care Med 160 2 (1999) 446-453
11. Wang C.G., Almirall J.J., Dolman C.S., Dandurand R.J., and Eidelman D.H. In vitro bronchial responsiveness in two highly inbred rat strains. J Appl Physiol 82 5 (1997) 1445-1452
12. Tao F.C., Shah S., Pradhan A.A., Tolloczko B., and Martin J.G. Enhanced calcium signaling to bradykinin in airway smooth muscle from hyperresponsive inbred rats. Am J Physiol-Lung Cell Mol Physiol 284 1 (2003) L90-L99
13. Tao F.C., Tolloczko B., Mitchell C.A., Powell W.S., and Martin J.G. Inositol (1,4,5)trisphosphate metabolism and enhanced calcium mobilization in airway smooth muscle of hyperresponsive rats. Am J Respir Cell Mol Biol 23 4 (2000) 514-520
14. Gil F.R., Leguillette R., Zitouni N.B., and Lauzon A- M. Myosin regulatory light chain phosphorylation in hyperresponsive airway smooth muscle. Proc Am Thor Soc 2[1] (2005) A504
15. Murphey S.M., Brown S., Miklos N., and Fireman P. Reagin synthesis in inbred strains of rats. Immunology 27 (1974) 245-253
16. Eidelman D.H., Bellofiore S., and Martin J.G. Late airway responses to antigen challenge in sensitized inbred rats. Am Rev Respir Dis 137 (1988) 1033-1037
17. Elwood W., Lotvall J.O., Barnes P.J., and Fan Chung K. Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized Brown-Norway rats. J Allergy Clin Immunol 88 (1991) 951-960
18. Mishima H., Hojo M., Watanabe A., Hamid Q.A., and Martin J.G. CD4+ T cells can induce airway hyperresponsiveness to allergen challenge in the Brown Norway rat. Am J Respir Crit Care Med 158 6 (1998) 1863-1870
19. Haczku A., Macary P., Huang T.J., Tsukagoshi H., Barnes P.J., Kay A.B., et al. Adoptive transfer of allergen-specific CD4+ T cells induces airway inflammation and hyperresponsiveness in Brown-Norway rats. Immunology 91 2 (1997) 176-185
20. Huang T.J., MacAry P.A., Kemeny D.M., and Chung K.F. Effect of CD8+ T-cell depletion on bronchial hyper- responsiveness and inflammation in sensitized and allergen-exposed Brown-Norway rats. Immunology 96 3 (1999) 416-423
21. Elwood W., Barnes P.J., and Fan Chung K. Airway hyperresponsiveness is associated with inflammatory cell infiltration in Brown-Norway rats. Int Arch Allergy Immunol 99 (1992) 91-97
22. Huang T.J., MacAry P.A., Eynott P., Moussavi A., Daniel K.C., Askenase P.W., et al. Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma. J Immunol 166 1 (2001) 207-217
23. Allam M., and Renzi P.M. Inhibition of GM-CSF/IL-3/IL-5 signaling by antisense oligodeoxynucleotides targeting the common beta chain of their receptors. Antisense Nucl Acid Drug Dev 11 5 (2001) 289-300
24. Nag S.S., Xu L.J., Hamid Q., and Renzi P.M. The effects of IL-5 on airway physiology and inflammation in rats. J Allergy Clin Immunol 111 3 (2003) 558-566
25. Nag S., Lamkhioued B., and Renzi P.M. Interleukin-2-induced increased airway responsiveness and lung Th2 cytokine expression occur after antigen challenge through the leukotriene pathway. Am J Respir Crit Care Med 165 11 (2002) 1540-1545
26. Tsukagoshi H., Sakamoto T., Xu W., Barnes P.J., and Chung K.F. Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats. J Allergy Clin Immunol 93 (1994) 464-469
27. Huang T.J., MacAry P.A., Wilke T., Kemeny D.M., and Chung K.F. Inhibitory effects of endogenous and exogenous interferon-gamma on bronchial hyperresponsiveness, allergic inflammation and T-helper 2 cytokines in Brown-Norway rats. Immunology 98 2 (1999) 280-288
28. Isogai S., Hamid Q., Minshall E., Miyake S., Yoshizawa Y., Taha R., et al. Interferon-gamma increases IL-12 mRNA expression and attentuates allergic late-onset airway responses in the Brown Norway rat. Eur Respir J 16 1 (2000) 22-29
29. Elwood W., Sakamoto T., Barnes P.J., and Chung K.F. Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet- activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the Brown Norway rat. Int Arch Allergy Immunol 103 (1994) 67-72
30. Elwood W., Lotvall J.O., Barnes P.J., and Chung K.F. Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitized Brown-Norway rats. Am Rev Respir Dis 145 (1992) 1289-1294
31. Renzi P.M., Du T., Sapienza S., Wang N.S., and Martin J.G. Acute effects of interleukin-2 on lung mechanics and airway responsiveness in rats. Am Rev Respir Dis 143 (1991) 380-385
32. Renzi P.M., Sapienza S., Waserman S., Du T., Olivenstein R., Wang N.S., et al. Effect of interleukin-2 on the airway response to antigen in the rat. Am Rev Respir Dis 146 (1992) 163-169
33. Demnati R., Fraser R., Ghezzo H., Martin J.G., Plaa G., and Malo J.L. Time-course of functional and pathological changes after a single high acute inhalation of chlorine in rats. Eur Respir J 11 4 (1998) 922-928
34. Depuydt P., Joos G.F., and Pauwels R.A. Ambient ozone concentrations induce airway hyperresponsiveness in some rat strains. Eur Respir J 14 1 (1999) 125-131
35. Schelegle E.S., Walby W.F., Alfaro M.F., Wong V.J., Putney L., Stovall M.Y., et al. Repeated episodes of ozone inhalation attenuates airway injury/repair and release of substance P, but not adaptation. Toxicol Appl Pharmacol 186 3 (2003) 127-142
36. Tsukagoshi H., Haddad E.B., Sun J., Barnes P.J., and Chung K.F. Ozone-induced airway hyperresponsiveness: role of superoxide anions, NEP, and BK receptors. J Appl Physiol 78 (1995) 1015-1022
37. Demnati R., Fraser R., Martin J.G., Plaa G., and Malo J.L. Effects of dexamethasone on functional and pathological changes in rat bronchi caused by high acute exposure to chlorine. Toxicol Sci 45 2 (1998) 242-246
38. Sorkness R., Clough J.J., Castleman W.L., and Lemanske Jr. R.F. Virus-induced airway obstruction and parasympathetic hyperresponsiveness in adult rats. Am J Respir Crit Care Med 150 (1995) 28-34
39. Wedde-Beer K., Hu C., Rodriguez M.M., and Piedimonte G. Leukotrienes mediate neurogenic inflammation in lungs of young rats infected with respiratory syncytial virus. Am J Physiol Lung Cell Mol Physiol 282 5 (2002) L1143-L1150
40. Rosenthal L.A., Mikus L.D., Tuffaha A., Mosser A.G., Sorkness R.L., and Lemanske Jr. R.F. Attenuated innate mechanisms of interferon-{gamma} production in rats susceptible to postviral airway dysfunction. Am J Respir Cell Mol Biol 30 5 (2004) 702-709
41. Sapienza S., Eidelman D.H., Renzi P.M., and Martin J.G. Role of leukotriene D4 in the early and late pulmonary responses of rats to allergen challenge. Am Rev Respir Dis 142 (1990) 353-358
42. Ihaku D., Cameron L., Suzuki M., Molet S., Martin J., and Hamid Q. Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5- expressing cells in Brown Norway rats. J Allergy Clin Immunol 104 6 (1999) 1147-1154
43. Martin J.G., Xu L- J., Toh M- Y., Olivenstein R., and Powell W.S. Leukotrienes in bile during the early and the late airway responses after allergen challenge of sensitized rats. Am Rev Respir Dis 147 (1993) 104-110
44. Yu W., Xu L., Martin J.G., and Powell W.S. Cellular infiltration and eicosanoid synthesis in Brown Norway rat lungs after allergen challenge. Am J Respir Cell Mol Biol 13 4 (1995) 477-486
45. Xu L., Olivenstein R., Martin J.G., and Powell W.S. Inhaled budesonide inhibits OVA-induced airway narrowing, inflammation, and cys-LT synthesis in BN rats. J Appl Physiol 89 5 (2000) 1852-1858
46. Dandurand R.J., Wang C.G., Laberge S., Martin J.G., and Eidelman D.H. In vitro allergic bronchoconstriction in the Brown Norway rat. Am J Respir Crit Care Med 149 (1994) 1499-1505
47. Rabb H.A., Olivenstein R., Issekutz T.B., Renzi P.M., and Martin J.G. The role of the leukocyte adhesion molecules VLA-4, LFA-1 and Mac-1 in allergic airway responses in the rat. Am J Respir Crit Care Med 149 (1994) 1186-1191
48. Watanabe A., Mishima H., Renzi P.M., Xu L.J., Hamid Q., and Martin J.G. Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T cells in Brown Norway rats. J Clin Invest 96 (1995) 1303-1310
49. Hojo M., Suzuki M., Maghni K., Hamid Q., Powell W.S., and Martin J.G. Role of cysteinyl leukotrienes in CD4(+) T cell-driven late allergic airway responses. J Pharmacol Exp Ther 293 2 (2000) 410-416
50. Suzuki M., Taha R., Ihaku D., Hamid Q.A., and Martin J.G. CD8+ T cells modulate late allergic airway responses in Brown Norway rats. J Immunol 163 10 (1999) 5574-5581
51. Isogai S., Rubin A., Maghni K., Ramos-Barbon D., Taha R., Yoshizawa Y., et al. The effects of CD8+gamma delta T cells on late allergic airway responses and airway inflammation in rats. J Allergy Clin Immunol 112 3 (2003) 547-555
52. Isogai S., Taha R., Tamaoka M., Yoshizawa Y., Hamid Q., and Martin J.G. CD8(+) alpha beta T cells can mediate late airway responses and airway eosinophilia in rats. J Allergy Clin Immunol 114 6 (2004) 1345-1352
53. Yang X.X., Powell W.S., Xu L.J., and Martin J.G. Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. J Appl Physiol 86 1 (1999) 152-158
54. Lambert R.K., Wiggs B.R., Kuwano K., Hogg J.C., and Pare P.D. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 74 6 (1993) 2771-2781
55. Sapienza S., Du T., Eidelman D.H., Wang N.S., and Martin J.G. Structural changes in the airways of sensitized Brown Norway rats after antigen challenge. Am Rev Respir Dis 144 (1991) 423-427
56. Panettieri R.A., Kurray R.K., Eszterhas A.J., Bilgen G., and Martin J.G. Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 274 18 (1998) L417-L424
57. Salmon M., Walsh D.A., Koto H., Barnes P.J., and Chung K.F. Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling. Eur Respir J 14 3 (1999) 633-641
58. Ramos-Barbon D., Presley J.F., Hamid Q.A., Fixman E.D., and Martin J.G. Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma. J Clin Invest 115 6 (2005) 1580-1589
59. Moir L.M., Leung S.Y., Eynott P.R., McVicker C.G., Ward J.P., Chung K.F., et al. Repeated allergen inhalation induces phenotypic modulation of airway smooth muscle in small bronchioles of sensitized rats. Am J Physiol Lung Cell Mol Physiol 284 1 (2003) L148-L159
60. Wang C.G., Du T., Xu L.J., and Martin J.G. Role of leukotriene D4 in allergen-induced increases in airway smooth muscle in the rat. Am Rev Respir Dis 148 (1993) 413-417
61. Salmon M., Walsh D.A., Huang T.J., Barnes P.J., Leonard T.B., Hay D.W., et al. Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats. Br J Pharmacol 127 5 (1999) 1151-1158
62. Salmon M., Liu Y.C., Mak J.C., Rousell J., Huang T.J., Hisada T., et al. Contribution of upregulated airway endothelin-1 expression to airway smooth muscle and epithelial cell DNA synthesis after repeated allergen exposure of sensitized Brown-Norway rats. Am J Respir Cell Mol Biol 23 5 (2000) 618-625
63. Leung S.Y., Eynott P., Nath P., and Chung K.F. Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features. J Allergy Clin Immunol 115 5 (2005) 989-996
64. Xu K.F., Vlahos R., Messina A., Bamford T.L., Bertram J.F., and Stewart A.G. Antigen-induced airway inflammation in the Brown Norway rat results in airway smooth muscle hyperplasia. J Appl Physiol 93 (2002) 1833-1840
65. Ressler B., Lee R.T., Randell S.H., Drazen J.M., and Kamm R.D. Molecular responses of rat tracheal epithelial cells to transmembrane pressure. Am J Physiol Lung Cell Mol Physiol 278 6 (2000) L1264-L1272
66. Eynott P.R., Paavolainen N., Groneberg D.A., Noble A., Salmon M., Nath P., et al. Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation. J Pharmacol Exp Ther 304 1 (2003) 22-29
67. Vanacker N.J., Palmans E., Pauwels R.A., and Kips J.C. Fluticasone inhibits the progression of allergen-induced structural airway changes. Clin Exp Allergy 32 6 (2002) 914-920
68. Pini L., Martin J.G., Hamid Q., and Ludwig M.S. Extracellular matrix (ECM) remodeling is more prominent in the peripheral airways of OA-challenged BN rats. Am J Respir Crit Care Med 169 (2004) A699
69. Long N.C., Abraham J., Kobzik L., Weller E.A., Krishna Murthy G.G., and Shore S.A. Respiratory tract inflammation during the induction of chronic bronchitis in rats: role of C-fibres. Eur Respir J 14 1 (1999) 46-56
70. Long N.C., Martin J.G., Pantano R., and Shore S.A. Airway hyperresponsiveness in a rat model of chronic bronchitis: role of C fibers. Am J Respir Crit Care Med 155 (1997) 1222-1229
71. Wagner J.G., Van Dyken S.J., Wierenga J.R., Hotchkiss J.A., and Harkema J.R. Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways. Toxicol Sci 74 2 (2003) 437-446
72. Smith K.R., Uyeminami D.L., Kodavanti U.P., Crapo J.D., Chang L.Y., and Pinkerton K.E. Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant. Free Radic Biol Med 33 8 (2002) 1106-1114
73. Smith K.R., Pinkerton K.E., Watanabe T., Pedersen T.L., Ma S.J., and Hammock B.D. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci USA 102 6 (2005) 2186-2191
74. Wright J.L., Sun J.P., and Vedal S. A longitudinal analysis of pulmonary function in rats during a 12 month cigarette smoke exposure. Eur Respir J 10 5 (1997) 1115-1119
75. Heckman C.A., and Dalbey W.E. Pathogenesis of lesions induced in rat lung by chronic tobacco smoke inhalation. J Natl Cancer Inst 69 1 (1982) 117-129
76. Ofulue A.F., and Ko M. Effects of depletion of neutrophils or macrophages on development of cigarette smoke-induced emphysema. Am J Physiol 277 1 Pt 1 (1999) L97-L105
77. Wright J.L., Sun J.P., and Churg A. Cigarette smoke exposure causes constriction of rat lung. Eur Respir J 14 5 (1999) 1095-1099
78. Wang R.D., Tai H., Xie C., Wang X., Wright J.L., and Churg A. Cigarette smoke produces airway wall remodeling in rat tracheal explants. Am J Respir Crit Care Med 168 10 (2003) 1232-1236
79. Xu L.J., Dandurand R.J., Lei M., and Eidelman D.H. Airway hyperresponsiveness in cigarette smoke-exposed rats. Lung 171 2 (1993) 95-107
80. Bellofiore S., Eidelman D.H., Macklem P.T., and Martin J.G. Effects of elastase-induced emphysema on airway responsiveness to methacholine in rats. J Appl Physiol 66 (1989) 506-612
81. Massaro G.D., and Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 3 6 (1997) 675-677
82. Lucey E.C., Goldstein R.H., Breuer R., Rexer B.N., Ong D.E., and Snider G.L. Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysema. Respiration 70 2 (2003) 200-205
83. Shigemura N., Sawa Y., Mizuno S., Ono M., Ohta M., Nakamura T., et al. Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats. Circulation 111 11 (2005) 1407-1414