메뉴 건너뛰기




Volumn 10, Issue 8, 2014, Pages 2366-2377

Identification and retrospective validation of T-cell epitopes in the hepatitis C virus genotype 4 proteome: An accelerated approach toward epitope-driven vaccine development

Author keywords

Genotype 4; Hepatitis C virus; Immune Epitope Database; Immunoinformatics; T cell epitopes; Vaccine; Validation

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 1; PROTEOME; VIRUS PROTEIN;

EID: 84908439506     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.29177     Document Type: Article
Times cited : (7)

References (68)
  • 1
    • 1642288430 scopus 로고    scopus 로고
    • [Updated 2013 Jul; Cited 2013 Nov 13]. Available from
    • World Health Organization. Hepatitis C fact sheet No164 [Internet]. [Updated 2013 Jul; Cited 2013 Nov 13]. Available from: http://www.who.int/mediacentre/factsheets/fs164/en/.
    • Hepatitis C Fact Sheet No164 [Internet]
  • 2
    • 84908464502 scopus 로고    scopus 로고
    • [Cited 2013 Nov 13]. Available from
    • World Health Organization. Hepatitis C [Internet]. 2002. [Cited 2013 Nov 13]. Available from: http://www.who.int/csr/disease/hepatitis/whocdscsrlyo2003/en/index2.html.
    • (2002) Hepatitis C [Internet]
  • 5
    • 81155137070 scopus 로고    scopus 로고
    • [Cited 2013 Nov 13]. Available from
    • Centers for Disease Control and Prevention. Hepatitis C Information for Health Professionals [Internet]. 2011. [Cited 2013 Nov 13]. Available from: http://www.cdc.gov/hepatitis/HCV/index.htm
    • (2011) Hepatitis C Information for Health Professionals [Internet]
  • 6
    • 34249024924 scopus 로고    scopus 로고
    • Replication of hepatitis C virus
    • PMID:17487147
    • Moradpour D, Penin F, Rice CM. Replication of hepatitis C virus. Nat Rev Microbiol 2007; 5:453-63; PMID:17487147; http://dx.doi.org/10.1038/nrmicro1645
    • (2007) Nat Rev Microbiol , vol.5 , pp. 453-463
    • Moradpour, D.1    Penin, F.2    Rice, C.M.3
  • 7
    • 46749154594 scopus 로고    scopus 로고
    • Immune responses during acute and chronic infection with hepatitis C virus
    • PMID:18514579
    • Ishii S, Koziel MJ. Immune responses during acute and chronic infection with hepatitis C virus. Clin Immunol 2008; 128:133-47; PMID:18514579; http://dx.doi.org/10.1016/j.clim.2008.03.525
    • (2008) Clin Immunol , vol.128 , pp. 133-147
    • Ishii, S.1    Koziel, M.J.2
  • 8
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
    • PMID:19587449
    • Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009; 119:1745-54; PMID:19587449; http://dx.doi.org/10.1172/JCI39133
    • (2009) J Clin Invest , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 9
    • 77954921919 scopus 로고    scopus 로고
    • Induction and evasion of innate antiviral responses by hepatitis C virus
    • PMID:20457596
    • Lemon SM. Induction and evasion of innate antiviral responses by hepatitis C virus. J Biol Chem 2010; 285:22741-7; PMID:20457596; http://dx.doi.org/10.1074/jbc.R109.099556
    • (2010) J Biol Chem , vol.285 , pp. 22741-22747
    • Lemon, S.M.1
  • 10
    • 47149098765 scopus 로고    scopus 로고
    • Host neutralizing responses and pathogenesis of hepatitis C virus infection
    • PMID:18508291
    • Zeisel MB, Cosset FL, Baumert TF. Host neutralizing responses and pathogenesis of hepatitis C virus infection. Hepatology 2008; 48:299-307; PMID:18508291; http://dx.doi.org/10.1002/hep.22307
    • (2008) Hepatology , vol.48 , pp. 299-307
    • Zeisel, M.B.1    Cosset, F.L.2    Baumert, T.F.3
  • 11
    • 79957622306 scopus 로고    scopus 로고
    • Vaccination for hepatitis C virus: Closing in on an evasive target
    • PMID:21604986
    • Halliday J, Klenerman P, Barnes E. Vaccination for hepatitis C virus: closing in on an evasive target. Expert Rev Vaccines 2011; 10:659-72; PMID:21604986; http://dx.doi.org/10.1586/erv.11.55
    • (2011) Expert Rev Vaccines , vol.10 , pp. 659-672
    • Halliday, J.1    Klenerman, P.2    Barnes, E.3
  • 12
    • 77954551369 scopus 로고    scopus 로고
    • A new insight into hepatitis C vaccine development
    • PMID:20625493
    • Yu CI, Chiang BL. A new insight into hepatitis C vaccine development. J Biomed Biotechnol 2010; 2010:548280; PMID:20625493; http://dx.doi.org/10.1155/2010/548280
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 548280
    • Yu, C.I.1    Chiang, B.L.2
  • 13
    • 77956168246 scopus 로고    scopus 로고
    • Metaanalysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins
    • PMID:20621699
    • Dahari H, Feinstone SM, Major ME. Metaanalysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins. Gastroenterology 2010; 139:965-74; PMID:20621699; http://dx.doi.org/10.1053/j.gastro.2010.05.077
    • (2010) Gastroenterology , vol.139 , pp. 965-974
    • Dahari, H.1    Feinstone, S.M.2    Major, M.E.3
  • 14
    • 84861695188 scopus 로고    scopus 로고
    • A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV)
    • PMID:22675428
    • Kim Y, Vaughan K, Greenbaum J, Peters B, Law M, Sette A. A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV). PLoS One 2012; 7:e38028; PMID:22675428; http://dx.doi.org/10.1371/journal.pone.0038028
    • (2012) PLoS One , vol.7 , pp. e38028
    • Kim, Y.1    Vaughan, K.2    Greenbaum, J.3    Peters, B.4    Law, M.5    Sette, A.6
  • 15
    • 79958808909 scopus 로고    scopus 로고
    • Global health: A uniquely Egyptian epidemic
    • PMID:21666728
    • Yahia M. Global health: a uniquely Egyptian epidemic. Nature 2011; 474:S12-3; PMID:21666728; http://dx.doi.org/10.1038/474S12a
    • (2011) Nature , vol.474 , pp. S12-S13
    • Yahia, M.1
  • 19
    • 0033388724 scopus 로고    scopus 로고
    • Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism
    • PMID:10602880
    • Sette A, Sidney J. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics 1999; 50:201-12; PMID:10602880; http://dx.doi.org/10.1007/s002510050594
    • (1999) Immunogenetics , vol.50 , pp. 201-212
    • Sette, A.1    Sidney, J.2
  • 20
    • 84855240713 scopus 로고    scopus 로고
    • Hepatitis C virus - T-cell responses and viral escape mutations
    • PMID:22125159
    • Petrovic D, Dempsey E, Doherty DG, Kelleher D, Long A. Hepatitis C virus - T-cell responses and viral escape mutations. Eur J Immunol 2012; 42:17-26; PMID:22125159; http://dx.doi.org/10.1002/eji.201141593
    • (2012) Eur J Immunol , vol.42 , pp. 17-26
    • Petrovic, D.1    Dempsey, E.2    Doherty, D.G.3    Kelleher, D.4    Long, A.5
  • 22
    • 34347336641 scopus 로고    scopus 로고
    • Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site
    • PMID:17554032
    • Neumann-Haefelin C, Killinger T, Timm J, Southwood S, McKinney D, Blum HE, Thimme R. Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site. J Gen Virol 2007; 88:1986-91; PMID:17554032; http://dx.doi.org/10.1099/vir.0.82826-0
    • (2007) J Gen Virol , vol.88 , pp. 1986-1991
    • Neumann-Haefelin, C.1    Killinger, T.2    Timm, J.3    Southwood, S.4    McKinney, D.5    Blum, H.E.6    Thimme, R.7
  • 24
    • 9344219963 scopus 로고    scopus 로고
    • Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome
    • PMID:8671652
    • Wentworth PA, Sette A, Celis E, Sidney J, Southwood S, Crimi C, Stitely S, Keogh E, Wong NC, Livingston B, et al. Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome. Int Immunol 1996; 8:651-9; PMID:8671652; http://dx.doi.org/10.1093/intimm/8.5.651
    • (1996) Int Immunol , vol.8 , pp. 651-659
    • Wentworth, P.A.1    Sette, A.2    Celis, E.3    Sidney, J.4    Southwood, S.5    Crimi, C.6    Stitely, S.7    Keogh, E.8    Wong, N.C.9    Livingston, B.10
  • 25
    • 33846781213 scopus 로고    scopus 로고
    • Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine
    • PMID:17225159
    • Mashiba T, Udaka K, Hirachi Y, Hiasa Y, Miyakawa T, Satta Y, Osoda T, Kataoka S, Kohara M, Onji M. Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine. Immunogenetics 2007; 59:197-209; PMID:17225159; http://dx.doi.org/10.1007/s00251-006-0185-3
    • (2007) Immunogenetics , vol.59 , pp. 197-209
    • Mashiba, T.1    Udaka, K.2    Hirachi, Y.3    Hiasa, Y.4    Miyakawa, T.5    Satta, Y.6    Osoda, T.7    Kataoka, S.8    Kohara, M.9    Onji, M.10
  • 26
    • 0037401613 scopus 로고    scopus 로고
    • Analysis of the CD8-positive T cell response in Japanese patients with chronic hepatitis C using HLA-A∗2402 peptide tetramers
    • PMID:12629644
    • Nakamoto Y, Kaneko S, Takizawa H, Kikumoto Y, Takano M, Himeda Y, Kobayashi K. Analysis of the CD8-positive T cell response in Japanese patients with chronic hepatitis C using HLA-A∗2402 peptide tetramers. J Med Virol 2003; 70:51-61; PMID:12629644; http://dx.doi.org/10.1002/jmv.10349
    • (2003) J Med Virol , vol.70 , pp. 51-61
    • Nakamoto, Y.1    Kaneko, S.2    Takizawa, H.3    Kikumoto, Y.4    Takano, M.5    Himeda, Y.6    Kobayashi, K.7
  • 27
    • 38449088067 scopus 로고    scopus 로고
    • Analysis of hepatitis C virus-specific CD8+ T-cells with HLA-A∗24 tetramers during phlebotomy and interferon therapy for chronic hepatitis C
    • PMID:17786365
    • Kaji K, Nakamoto Y, Kaneko S. Analysis of hepatitis C virus-specific CD8+ T-cells with HLA-A∗24 tetramers during phlebotomy and interferon therapy for chronic hepatitis C. Oncol Rep 2007; 18:993-8; PMID:17786365
    • (2007) Oncol Rep , vol.18 , pp. 993-998
    • Kaji, K.1    Nakamoto, Y.2    Kaneko, S.3
  • 29
    • 0032870465 scopus 로고    scopus 로고
    • Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus
    • PMID:10498657
    • Christie JM, Chapel H, Chapman RW, Rosenberg WM. Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus. Hepatology 1999; 30:1037-44; PMID:10498657; http://dx.doi.org/10.1002/hep.510300403
    • (1999) Hepatology , vol.30 , pp. 1037-1044
    • Christie, J.M.1    Chapel, H.2    Chapman, R.W.3    Rosenberg, W.M.4
  • 30
    • 4444354594 scopus 로고    scopus 로고
    • High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection
    • PMID:15362047
    • Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Robbins GK, Casson DR, Reiser M, et al. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004; 127:924-36; PMID:15362047; http://dx.doi.org/10.1053/j.gastro.2004.06.015
    • (2004) Gastroenterology , vol.127 , pp. 924-936
    • Lauer, G.M.1    Barnes, E.2    Lucas, M.3    Timm, J.4    Ouchi, K.5    Kim, A.Y.6    Day, C.L.7    Robbins, G.K.8    Casson, D.R.9    Reiser, M.10
  • 33
    • 0036116355 scopus 로고    scopus 로고
    • Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities
    • PMID:12021343
    • Lauer GM, Ouchi K, Chung RT, Nguyen TN, Day CL, Purkis DR, Reiser M, Kim AY, Lucas M, Klenerman P, et al. Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol 2002; 76:6104-13; PMID:12021343; http://dx.doi.org/10.1128/JVI.76.12.6104-6113.2002
    • (2002) J Virol , vol.76 , pp. 6104-6113
    • Lauer, G.M.1    Ouchi, K.2    Chung, R.T.3    Nguyen, T.N.4    Day, C.L.5    Purkis, D.R.6    Reiser, M.7    Kim, A.Y.8    Lucas, M.9    Klenerman, P.10
  • 34
    • 0028578149 scopus 로고
    • Class I MHC-peptide interactions: Structural requirements and functional implications
    • PMID:7536628
    • Grey HM, Ruppert J, Vitiello A, Sidney J, Kast WM, Kubo RT, Sette A. Class I MHC-peptide interactions: structural requirements and functional implications. Cancer Surv 1995; 22:37-49; PMID:7536628
    • (1995) Cancer Surv , vol.22 , pp. 37-49
    • Grey, H.M.1    Ruppert, J.2    Vitiello, A.3    Sidney, J.4    Kast, W.M.5    Kubo, R.T.6    Sette, A.7
  • 35
    • 0027304399 scopus 로고
    • Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules
    • PMID:8104103
    • Ruppert J, Sidney J, Celis E, Kubo RT, Grey HM, Sette A. Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules. Cell 1993; 74:929-37; PMID:8104103; http://dx.doi.org/10.1016/0092-8674(93)90472-3
    • (1993) Cell , vol.74 , pp. 929-937
    • Ruppert, J.1    Sidney, J.2    Celis, E.3    Kubo, R.T.4    Grey, H.M.5    Sette, A.6
  • 37
    • 0032402264 scopus 로고    scopus 로고
    • Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity
    • PMID:9831133
    • Alexander J, Del Guercio MF, Fikes JD, Chesnut RW, Chisari FV, Chang KM, Appella E, Sette A. Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity. Hum Immunol 1998; 59:776-82; PMID:9831133; http://dx.doi.org/10.1016/S0198-8859(98)00080-9
    • (1998) Hum Immunol , vol.59 , pp. 776-782
    • Alexander, J.1    Del Guercio, M.F.2    Fikes, J.D.3    Chesnut, R.W.4    Chisari, F.V.5    Chang, K.M.6    Appella, E.7    Sette, A.8
  • 39
    • 0034767643 scopus 로고    scopus 로고
    • Majority of peptides binding HLA-A∗0201 with high affinity crossreact with other A2-supertype molecules
    • PMID:11704282
    • Sidney J, Southwood S, Mann DL, Fernandez-Vina MA, Newman MJ, Sette A. Majority of peptides binding HLA-A∗0201 with high affinity crossreact with other A2-supertype molecules. Hum Immunol 2001; 62:1200-16; PMID:11704282; http://dx.doi.org/10.1016/S0198-8859(01)00319-6
    • (2001) Hum Immunol , vol.62 , pp. 1200-1216
    • Sidney, J.1    Southwood, S.2    Mann, D.L.3    Fernandez-Vina, M.A.4    Newman, M.J.5    Sette, A.6
  • 40
    • 0036891882 scopus 로고    scopus 로고
    • Comparative vaccine studies in HLA-A2.1-transgenic mice reveal a clustered organization of epitopes presented in hepatitis C virus natural infection
    • PMID:12438599
    • Himoudi N, Abraham JD, Fournillier A, Lone YC, Joubert A, Op De Beeck A, Freida D, Lemonnier F, Kieny MP, Inchauspé G. Comparative vaccine studies in HLA-A2.1-transgenic mice reveal a clustered organization of epitopes presented in hepatitis C virus natural infection. J Virol 2002; 76:12735-46; PMID:12438599; http://dx.doi.org/10.1128/JVI.76.24.12735-12746.2002
    • (2002) J Virol , vol.76 , pp. 12735-12746
    • Himoudi, N.1    Abraham, J.D.2    Fournillier, A.3    Lone, Y.C.4    Joubert, A.5    Op De Beeck, A.6    Freida, D.7    Lemonnier, F.8    Kieny, M.P.9    Inchauspé, G.10
  • 41
    • 0028962927 scopus 로고
    • Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules
    • PMID:7884894
    • Battegay M, Fikes J, Di Bisceglie AM, Wentworth PA, Sette A, Celis E, Ching WM, Grakoui A, Rice CM, Kurokohchi K, et al. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J Virol 1995; 69:2462-70; PMID:7884894
    • (1995) J Virol , vol.69 , pp. 2462-2470
    • Battegay, M.1    Fikes, J.2    Di Bisceglie, A.M.3    Wentworth, P.A.4    Sette, A.5    Celis, E.6    Ching, W.M.7    Grakoui, A.8    Rice, C.M.9    Kurokohchi, K.10
  • 42
    • 33750945696 scopus 로고    scopus 로고
    • Immunogenic variation between multiple HLA-A∗0201-restricted, Hepatitis C Virus-derived epitopes for cytotoxic T lymphocytes
    • PMID:16987064
    • Ohno S, Moriya O, Yoshimoto T, Hayashi H, Akatsuka T, Matsui M. Immunogenic variation between multiple HLA-A∗0201-restricted, Hepatitis C Virus-derived epitopes for cytotoxic T lymphocytes. Viral Immunol 2006; 19:458-67; PMID:16987064; http://dx.doi.org/10.1089/vim.2006.19.458
    • (2006) Viral Immunol , vol.19 , pp. 458-467
    • Ohno, S.1    Moriya, O.2    Yoshimoto, T.3    Hayashi, H.4    Akatsuka, T.5    Matsui, M.6
  • 44
    • 0036088884 scopus 로고    scopus 로고
    • Comprehensive determinant mapping of the hepatitis C-specific CD8 cell repertoire reveals unpredicted immune hierarchy
    • PMID:12173301
    • Anthony DD, Valdez H, Post AB, Carlson NL, Heeger PS, Lehmann PV. Comprehensive determinant mapping of the hepatitis C-specific CD8 cell repertoire reveals unpredicted immune hierarchy. Clin Immunol 2002; 103:264-76; PMID:12173301; http://dx.doi.org/10.1006/clim.2001.5193
    • (2002) Clin Immunol , vol.103 , pp. 264-276
    • Anthony, D.D.1    Valdez, H.2    Post, A.B.3    Carlson, N.L.4    Heeger, P.S.5    Lehmann, P.V.6
  • 45
    • 80053566559 scopus 로고    scopus 로고
    • Molecular footprints reveal the impact of the protective HLA-A∗03 allele in hepatitis C virus infection
    • PMID:21551190
    • Fitzmaurice K, Petrovic D, Ramamurthy N, Simmons R, Merani S, Gaudieri S, Sims S, Dempsey E, Freitas E, Lea S, et al. Molecular footprints reveal the impact of the protective HLA-A∗03 allele in hepatitis C virus infection. Gut 2011; 60:1563-71; PMID:21551190; http://dx.doi.org/10.1136/gut.2010.228403
    • (2011) Gut , vol.60 , pp. 1563-1571
    • Fitzmaurice, K.1    Petrovic, D.2    Ramamurthy, N.3    Simmons, R.4    Merani, S.5    Gaudieri, S.6    Sims, S.7    Dempsey, E.8    Freitas, E.9    Lea, S.10
  • 46
    • 0037261447 scopus 로고    scopus 로고
    • Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: Tetramer assay and therapeutic implications
    • PMID:12566993
    • Tsai SL, Sheen IS, Chien RN, Chu CM, Huang HC, Chuang YL, Lee TH, Liao SK, Lin CL, Kuo GC, et al. Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: tetramer assay and therapeutic implications. J Biomed Sci 2003; 10:120-35; PMID:12566993; http://dx.doi.org/10.1007/BF02256004
    • (2003) J Biomed Sci , vol.10 , pp. 120-135
    • Tsai, S.L.1    Sheen, I.S.2    Chien, R.N.3    Chu, C.M.4    Huang, H.C.5    Chuang, Y.L.6    Lee, T.H.7    Liao, S.K.8    Lin, C.L.9    Kuo, G.C.10
  • 47
    • 1042292703 scopus 로고    scopus 로고
    • A method to increase tetramer staining efficiency of CD8+ T cells with MHC-peptide complexes: Therapeutic applications in monitoring cytotoxic T lymphocyte activity during hepatitis B and C treatment
    • PMID:14871536
    • Tsai SL, Lee TH, Chien RN, Liao SK, Lin CL, Kuo GC, Liaw YF. A method to increase tetramer staining efficiency of CD8+ T cells with MHC-peptide complexes: therapeutic applications in monitoring cytotoxic T lymphocyte activity during hepatitis B and C treatment. J Immunol Methods 2004; 285:71-87; PMID:14871536; http://dx.doi.org/10.1016/j.jim.2003.11.005
    • (2004) J Immunol Methods , vol.285 , pp. 71-87
    • Tsai, S.L.1    Lee, T.H.2    Chien, R.N.3    Liao, S.K.4    Lin, C.L.5    Kuo, G.C.6    Liaw, Y.F.7
  • 49
    • 84862174259 scopus 로고    scopus 로고
    • DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response
    • PMID:22701633
    • Guo Z, Zhang H, Rao H, Jiang D, Cong X, Feng B, Wang J, Wei L, Chen H. DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response. PLoS One 2012; 7:e38390; PMID:22701633; http://dx.doi.org/10.1371/journal.pone.0038390
    • (2012) PLoS One , vol.7 , pp. e38390
    • Guo, Z.1    Zhang, H.2    Rao, H.3    Jiang, D.4    Cong, X.5    Feng, B.6    Wang, J.7    Wei, L.8    Chen, H.9
  • 50
    • 39649122106 scopus 로고    scopus 로고
    • HLA class I supertypes: A revised and updated classification
    • PMID:18211710
    • Sidney J, Peters B, Frahm N, Brander C, Sette A. HLA class I supertypes: a revised and updated classification. BMC Immunol 2008; 9:1; PMID:18211710; http://dx.doi.org/10.1186/1471-2172-9-1
    • (2008) BMC Immunol , vol.9 , pp. 1
    • Sidney, J.1    Peters, B.2    Frahm, N.3    Brander, C.4    Sette, A.5
  • 53
    • 0032806953 scopus 로고    scopus 로고
    • Role of the specific T-cell response for clearance and control of hepatitis C virus
    • PMID:10760033
    • Pape GR, Gerlach TJ, Diepolder HM, Grüner N, Jung M, Santantonio T. Role of the specific T-cell response for clearance and control of hepatitis C virus. J Viral Hepat 1999; 6(Suppl 1):36-40; PMID:10760033; http://dx.doi.org/10.1046/j.1365-2893.1999.00006.x
    • (1999) J Viral Hepat , vol.6 , pp. 36-40
    • Pape, G.R.1    Gerlach, T.J.2    Diepolder, H.M.3    Grüner, N.4    Jung, M.5    Santantonio, T.6
  • 54
    • 0346734182 scopus 로고    scopus 로고
    • Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections
    • PMID:14688358
    • Shoukry NH, Sidney J, Sette A, Walker CM. Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections. J Immunol 2004; 172:483-92; PMID:14688358; http://dx.doi.org/10.4049/jimmunol.172.1.483
    • (2004) J Immunol , vol.172 , pp. 483-492
    • Shoukry, N.H.1    Sidney, J.2    Sette, A.3    Walker, C.M.4
  • 57
    • 0032870469 scopus 로고    scopus 로고
    • Conserved hepatitis C virus sequences are highly immunogenic for CD4(+) T cells: Implications for vaccine development
    • PMID:10498664
    • Lamonaca V, Missale G, Urbani S, Pilli M, Boni C, Mori C, Sette A, Massari M, Southwood S, Bertoni R, et al. Conserved hepatitis C virus sequences are highly immunogenic for CD4(+) T cells: implications for vaccine development. Hepatology 1999; 30:1088-98; PMID:10498664; http://dx.doi.org/10.1002/hep.510300435
    • (1999) Hepatology , vol.30 , pp. 1088-1098
    • Lamonaca, V.1    Missale, G.2    Urbani, S.3    Pilli, M.4    Boni, C.5    Mori, C.6    Sette, A.7    Massari, M.8    Southwood, S.9    Bertoni, R.10
  • 58
    • 3242680535 scopus 로고    scopus 로고
    • Longitudinal mapping of protective CD4+ T cell responses against HCV: Analysis of fluctuating dominant and subdominant HLA-DR11 restricted epitopes
    • PMID:15230855
    • Harcourt GC, Lucas M, Sheridan I, Barnes E, Phillips R, Klenerman P. Longitudinal mapping of protective CD4+ T cell responses against HCV: analysis of fluctuating dominant and subdominant HLA-DR11 restricted epitopes. J Viral Hepat 2004; 11:324-31; PMID:15230855; http://dx.doi.org/10.1111/j.1365-2893.2004.00516.x
    • (2004) J Viral Hepat , vol.11 , pp. 324-331
    • Harcourt, G.C.1    Lucas, M.2    Sheridan, I.3    Barnes, E.4    Phillips, R.5    Klenerman, P.6
  • 59
    • 43249107955 scopus 로고    scopus 로고
    • Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection
    • PMID:18337568
    • Ebinuma H, Nakamoto N, Li Y, Price DA, Gostick E, Levine BL, Tobias J, Kwok WW, Chang KM. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J Virol 2008; 82:5043-53; PMID:18337568; http://dx.doi.org/10.1128/JVI.01548-07
    • (2008) J Virol , vol.82 , pp. 5043-5053
    • Ebinuma, H.1    Nakamoto, N.2    Li, Y.3    Price, D.A.4    Gostick, E.5    Levine, B.L.6    Tobias, J.7    Kwok, W.W.8    Chang, K.M.9
  • 60
    • 0036233361 scopus 로고    scopus 로고
    • Epitopes of the NS3 protein of hepatitis C virus: Recognition in HLA-DR4 transgenic mice
    • PMID:11869368
    • Eckels DD, Bian T, Gill JC, Sønderstrup G. Epitopes of the NS3 protein of hepatitis C virus: recognition in HLA-DR4 transgenic mice. Immunol Cell Biol 2002; 80:106-12; PMID:11869368; http://dx.doi.org/10.1046/j.1440-1711.2002.01053.x
    • (2002) Immunol Cell Biol , vol.80 , pp. 106-112
    • Eckels, D.D.1    Bian, T.2    Gill, J.C.3    Sønderstrup, G.4
  • 62
    • 24744453723 scopus 로고    scopus 로고
    • Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
    • PMID:16148104
    • Schulze zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, et al. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol 2005; 175:3603-13; PMID:16148104; http://dx.doi.org/10.4049/jimmunol.175.6.3603
    • (2005) J Immunol , vol.175 , pp. 3603-3613
    • Schulze Zur Wiesch, J.1    Lauer, G.M.2    Day, C.L.3    Kim, A.Y.4    Ouchi, K.5    Duncan, J.E.6    Wurcel, A.G.7    Timm, J.8    Jones, A.M.9    Mothe, B.10
  • 63
    • 82155191792 scopus 로고    scopus 로고
    • Neutralizing antibody response to hepatitis C virus
    • PMID:22163337
    • Wang Y, Keck ZY, Foung SK. Neutralizing antibody response to hepatitis C virus. Viruses 2011; 3:2127-45; PMID:22163337; http://dx.doi.org/10.3390/v3112127
    • (2011) Viruses , vol.3 , pp. 2127-2145
    • Wang, Y.1    Keck, Z.Y.2    Foung, S.K.3
  • 64
    • 84896972686 scopus 로고    scopus 로고
    • Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage
    • He L, De Groot AS, Gutierrez AH, Martin WD, Moise L, Bailey-Kellogg C. Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage. BMC Bioinformatics 2014; 15:S1
    • (2014) BMC Bioinformatics , vol.15 , pp. S1
    • He, L.1    De Groot, A.S.2    Gutierrez, A.H.3    Martin, W.D.4    Moise, L.5    Bailey-Kellogg, C.6
  • 65
    • 63749128279 scopus 로고    scopus 로고
    • Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics
    • PMID:19269256
    • De Groot AS, Martin W. Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics. Clin Immunol 2009; 131:189-201; PMID:19269256; http://dx.doi.org/10.1016/j.clim.2009.01.009
    • (2009) Clin Immunol , vol.131 , pp. 189-201
    • De Groot, A.S.1    Martin, W.2
  • 66
    • 84897374046 scopus 로고    scopus 로고
    • Preexisting CD4+ T-cell immunity in human population to avian influenza H7N9 virus: Whole proteome-wide immunoinformatics analyses
    • PMID:24609014
    • Duvvuri VR, Duvvuri B, Alice C, Wu GE, Gubbay JB, Wu J. Preexisting CD4+ T-cell immunity in human population to avian influenza H7N9 virus: whole proteome-wide immunoinformatics analyses. PLoS One 2014; 9:e91273; PMID:24609014; http://dx.doi.org/10.1371/journal.pone.0091273
    • (2014) PLoS One , vol.9 , pp. e91273
    • Duvvuri, V.R.1    Duvvuri, B.2    Alice, C.3    Wu, G.E.4    Gubbay, J.B.5    Wu, J.6
  • 67
    • 84890757693 scopus 로고    scopus 로고
    • Sofosbuvir for the treatment of hepatitis C virus
    • PMID:24289735
    • Asselah T. Sofosbuvir for the treatment of hepatitis C virus. Expert Opin Pharmacother 2014; 15:121-30; PMID:24289735; http://dx.doi.org/10.1517/14656566.2014.857656
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 121-130
    • Asselah, T.1
  • 68
    • 13844253602 scopus 로고    scopus 로고
    • The Los Alamos hepatitis C sequence database
    • PMID:15377502
    • Kuiken C, Yusim K, Boykin L, Richardson R. The Los Alamos hepatitis C sequence database. Bioinformatics 2005; 21:379-84; PMID:15377502; http://dx.doi.org/10.1093/bioinformatics/bth485
    • (2005) Bioinformatics , vol.21 , pp. 379-384
    • Kuiken, C.1    Yusim, K.2    Boykin, L.3    Richardson, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.