Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus

Hepatology

Volumn 30, Issue 4, 1999, Pages 1037-1044

  Christie, John M L ^a,c   Chapel, Helen ^b   Chapman, Roger W ^a   Rosenberg, William M C ^c,d  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; EPITOPE; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; HEPATITIS C VIRUS; HOST RESISTANCE; HUMAN; HUMORAL IMMUNE DEFICIENCY; MALE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIRUS CELL INTERACTION; VIRUS MUTATION;

ADULT; AGAMMAGLOBULINEMIA; AGED; AMINO ACID SEQUENCE; ANTIBODIES; B-LYMPHOCYTES; BASE SEQUENCE; EPITOPES; FEMALE; HEPACIVIRUS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MOLECULAR SEQUENCE DATA; MUTATION; REFERENCE VALUES; T-LYMPHOCYTES, CYTOTOXIC; VARIATION (GENETICS); VIRAL CORE PROTEINS; VIRAL ENVELOPE PROTEINS;

EID: 0032870465     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300403     Document Type: Article

References (15)

1. Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice CM. Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993;67:1385-1395.
2. Simmonds P, Holmes EC, Cha TA, Chan SW, McOmish F, Irvine B, Beall E, et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol 1993;74:2391-2399.
3. Bukh J, Miller RH, Purcell RH. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin Liver Dis 1995;15:41-63.
4. Houghton M. Hepatitis C virus. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology. Philadelphia: Lippincott-Raven, 1996:1035-1058.
5. Weiner AJ, Brauer MJ, Rosenblatt J, Richman KH, Tung J, Crawford K, Bonino F, et al. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 1991;180:842-848.
6. Weiner AJ, Geysen HM, Christopherson C, Hall JE, Mason TJ, Saracco G, Bonino F, et al. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci U S A 1992;89:3468-3472.
7. Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 1991;354:453-459.
8. Goulder PJ, Sewell AK, Lalloo DG, Price DA, Whelan JA, Evans J, Taylor GP, et al. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J Exp Med 1997;185:1423-1433.
9. de Campos Lima PO, Gavioli R, Zhang QJ, Wallace LE, Dolcetti R, Rowe M, Rickinson AB, et al. HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population. Science 1993;260:98-100.
10. Price DA, Goulder PJ, Klenerman P, Sewell AK, Easterbrook PJ, Troop M, Bangham CR, et al. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci U S A 1997;94:1890-1895.
11. Weiner A, Erickson AL, Kansopon J, Crawford K, Muchmore E, Hughes AL, Houghton M, et al. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci U S A 1995;92:2755-2759.
12. Chang KM, Rehermann B, McHutchison JG, Pasquinelli C, Southwood S, Sette A, Chisari FV. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J Clin Invest 1997;100:2376-2385.
13. Kumar U, Monjardino J, Thomas HC. Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient. Gastroenterology 1994;106:1072-1075.
14. Booth JC, Kumar U, Webster D, Monjardino J, Thomas HC. Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients. HEPATOLOGY 1998;27:223-227.
15. Healey CJ, Sabharwal NK, McOmish F, Chapman RWG, Fleming K, Chapel H. Outbreak of acute hepatitis C following intravenous immunoglobulin therapy. HEPATOLOGY 1994;20:249A.