Role of the specific T-cell response for clearance and control of hepatitis C virus

Journal of Viral Hepatitis

Volumn 6, Issue SUPPL. 1, 1999, Pages 36-40

  Pape, G R ^a,b   Gerlach, T J ^a,b   Diepolder, H M ^a,b   Gruner N ^b   Jung, M C ^a,b   Santantonio, T ^c  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Acute hepatitis; CD4; CD8; Immune response; Peptide; Viral hepatitis

Indexed keywords

EPITOPE; HLA DR ANTIGEN; LYMPHOKINE; PEPTIDE; VIRUS PROTEIN;

ACUTE HEPATITIS; ANTIGEN BINDING; ANTIGEN PRESENTATION; BINDING AFFINITY; CELLULAR IMMUNITY; CHRONIC HEPATITIS; CONFERENCE PAPER; HELPER CELL; HEPATITIS C; HEPATITIS C VIRUS; HLA SYSTEM; HUMAN; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS IMMUNITY;

CD4-POSITIVE T-LYMPHOCYTES; HEPACIVIRUS; HUMANS;

EID: 0032806953     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.1999.00006.x     Document Type: Article

References (15)

1. Hoffmann RM, Diepolder HM, Zachoval R et al. Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection. Hepatology 1995; 21: 632-638.
2. Diepolder HM, Zachoval R, Hoffmann RM et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995; 346: 1006-1007.
3. Diepolder HM, Gerlach JT, Zachoval R et al. Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection. J Virol 1997; 71: 6011-6019.
4. Ferrari C, Valli A, Galati L et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology 1994; 19: 286-295.
5. Leroux Roels G, Esquivel CA, DeLeys R et al. Lymphoproliferative responses to hepatitis C virus core, E1, E2, and NS3 in patients with chronic hepatitis C infection treated with interferon alfa. Hepatology 1996; 23: 8-16.
6. Botarelli P, Brunetto MR, Minutello MA et al. T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology 1993; 104: 580-587.
7. Lechmann M, Ihlenfeldt HG, Braunschweiger I et al. T-and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia. Hepatology 1996; 24: 790-795.
8. Tsai S-L, Chen P-J, Hwang L-H, Kao J-H, Huang J-H, Chang T-H, Chen D-S. Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection. J Hepatol 1994; 21: 403-411.
9. Minutello MA, Pileri P, Unutmaz D et al. Compartmentalization of T lymphocytes to the site of disease: Intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. J Exp Med 1993; 178: 17-25.
10. Koziel M, Dudley D, Afdhal N et al. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. J Clin Invest 1995; 96: 2311-2321.
11. Cerny A, McHutchison JG, Pasquinelli C et al. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest 1995; 95: 521-530.
12. Battegay M, Fikes J, Di Bisceglie AM et al. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J Virol 1995; 69: 2462-2470.
13. Rehermann B, Chang K-M, McHutchison JG, Kokka R, Houghton M, Chisari FV. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J Clin Invest 1996; 98: 1432-1440.
14. Chang KM, Gruener NH, Southwood S, Sidney J, Pape GR, Chisari FV, Sette A. Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C. J Immunol 1999; 162: 1156-1164.
15. Meisel H, Reip A, Faltus B et al. Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin [see comments]. Lancet 1995; 345: 1209-1211.