Metabolomic identification of molecular changes associated with stress resilience in the chronic mild stress rat model of depression

Metabolomics

Volumn 9, Issue 2, 2013, Pages 433-443

  Shao, Wei Hua ^a,b   Fan, Song Hua ^a,b   Lei, Yang ^a,b   Yao, Guo En ^a,b   Chen, Jian Jun ^a,b   Zhou, Jian ^a,b   Xu, Hong Bo ^a,b   Liu, Hai Peng ^a,b   Wu, Bo ^a,b   Zheng, Peng ^a,b   Fang, Liang ^a,b   Xie, Peng ^a,b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING KEY LABORATORY OF NEUROBIOLOGY   (China)

Author keywords

Cerebellum; Chronic mild stress (CMS); GC MS; Major depressive disorder (MDD); Metabolomic; Stress resilience

Indexed keywords

DIHYDROXYACETONE PHOSPHATE; GLUTAMINE; LYSINE; PROLINE;

AMINO ACID ANALYSIS; ANHEDONIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CHRONIC STRESS; CONTROLLED STUDY; INDIVIDUALITY; LONG TERM EXPOSURE; MAJOR DEPRESSION; MASS FRAGMENTOGRAPHY; METABOLITE; METABOLOMICS; MOLECULAR DYNAMICS; MOUSE; NEUROCHEMISTRY; NONHUMAN; STRESS; STRESS RESILIENCE;

RATTUS;

EID: 84875484742     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-012-0460-2     Document Type: Article

References (57)

1. Bernard, R., Kerman, I. A., Thompson, R. C., et al. (2011). Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Molecular Psychiatry, 16(6), 634-646.
2. Beyer, J. L., & Krishnan, K. R. (2002). Volumetric brain imaging findings in mood disorders. Bipolar Disorders, 4(2), 89-104.
3. Bisgaard, C. F., Jayatissa, M. N., Enghild, J. J., Sanchez, C., Artemychyn, R., & Wiborg, O. (2007). Proteomic investigation of the ventral rat hippocampus links DRP-2 to escitalopram treatment resistance and SNAP to stress resilience in the chronic mild stress model of depression. Journal of Molecular Neuroscience, 32(2), 132-144.
4. Choudary, P. V., Molnar, M., Evans, S. J., et al. (2005). Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proceedings of the National Academy of Sciences of the United States of America, 102(43), 15653-15658.
5. Christensen, T., Bisgaard, C. F., & Wiborg, O. (2011). Biomarkers of anhedonic-like behavior, antidepressant drug refraction, and stress resilience in a rat model of depression. Neuroscience, 196, 66-79.
6. Fatemi, S. H., Laurence, J. A., Araghi-Niknam, M., et al. (2004). Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophrenia. Schizophrenia Research, 69(2-3), 317-323.
7. Feder, A., Nestler, E. J., & Charney, D. S. (2009). Psychobiology and molecular genetics of resilience. Nature Reviews Neuroscience, 10(6), 446-457.
8. Gersner, R., Toth, E., Isserles, M., & Zangen, A. (2010). Site-specific antidepressant effects of repeated subconvulsive electrical stimulation: Potential role of brain-derived neurotrophic factor. Biological Psychiatry, 67(2), 125-132.
9. Greer, T. L., Trivedi, M. H., & Thompson, L. T. (2005). Impaired delay and trace eyeblink conditioning performance in major depressive disorder. Journal of Affective Disorders, 86(2-3), 235-245.
10. Hamasu, K., Haraguchi, T., Kabuki, Y., et al. (2009). l-proline is a sedative regulator of acute stress in the brain of neonatal chicks. Amino Acids, 37(2), 377-382.
11. Hamasu, K., Shigemi, K., Tsuneyoshi, Y., et al. (2010). Intracerebroventricular injection of l-proline and d-proline induces sedative and hypnotic effects by different mechanisms under an acute stressful condition in chicks. Amino Acids, 38(1), 57-64.
12. Henningsen, K., Palmfeldt, J., Christiansen, S., et al. (2012). Hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression. Molecular & Cellular Proteomics. doi: 10. 1074/mcp. M111. 016428mcp. M111. 016428.
13. Hoppenbrouwers, S. S., Schutter, D. J., Fitzgerald, P. B., Chen, R., & Daskalakis, Z. J. (2008). The role of the cerebellum in the pathophysiology and treatment of neuropsychiatric disorders: A review. Brain Research Reviews, 59(1), 185-200.
14. Ito, M. (2006). Cerebellar circuitry as a neuronal machine. Progress in Neurobiology, 78(3-5), 272-303.
15. Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999). Causal relationship between stressful life events and the onset of major depression. The American Journal of Psychiatry, 156(6), 837-841.
16. Kessler, R. C. (1997). The effects of stressful life events on depression. Annual Review of Psychology, 48, 191-214.
17. Kessler, R. C., Berglund, P., Demler, O., et al. (2003). The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). The Journal of the American Medical Association, 289(23), 3095-3105.
18. Kimbrell, T. A., Ketter, T. A., George, M. S., et al. (2002). Regional cerebral glucose utilization in patients with a range of severities of unipolar depression. Biological Psychiatry, 51(3), 237-252.
19. Konarski, J. Z., McIntyre, R. S., Grupp, L. A., & Kennedy, S. H. (2005). Is the cerebellum relevant in the circuitry of neuropsychiatric disorders? Journal of Psychiatry and Neuroscience, 30(3), 178-186.
20. Lawson, A., Ahima, R. S., Krozowski, Z., & Harlan, R. E. (1992). Postnatal development of corticosteroid receptor immunoreactivity in the rat cerebellum and brain stem. Neuroendocrinology, 55(6), 695-707.
21. Li, Z. Y., Zheng, X. Y., Gao, X. X., et al. (2010). Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry, 24(24), 3539-3546.
22. Liu, Z., Xu, C., Xu, Y., et al. (2010). Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression. Psychiatry Research, 182(3), 211-215.
23. Liu, L., Zeng, L. L., Li, Y., et al. (2012). Altered cerebellar functional connectivity with intrinsic connectivity networks in adults with major depressive disorder. PLoS One, 7(6), e39516. doi: 10. 1371/journal. pone. 0039516.
24. Lucca, G., Comim, C. M., Valvassori, S. S., et al. (2009). Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm. Journal of Psychiatric Research, 43(9), 864-869.
25. Luedemann, A., Strassburg, K., Erban, A., & Kopka, J. (2008). TagFinder for the quantitative analysis of gas chromatography-mass spectrometry (GC-MS)-based metabolite profiling experiments. Bioinformatics, 24(5), 732-737.
26. Madtes, P, Jr, & King, J. S. (1999). The temporal and spatial development of CRF binding sites in the postnatal mouse cerebellum. Neuroscience Research, 34(1), 45-50.
27. Mazzocchi, G., Andreis, P. G., De Caro, R., Aragona, F., Gottardo, L., & Nussdorfer, G. G. (1999). Cerebellin enhances in vitro secretory activity of human adrenal gland. The Journal of Cinical Endocrinology and Metabolism, 84(2), 632-635.
28. Miguel-Hidalgo, J. J., Waltzer, R., Whittom, A. A., Austin, M. C., Rajkowska, G., & Stockmeier, C. A. (2010). Glial and glutamatergic markers in depression, alcoholism, and their comorbidity. Journal of Affective Disorders, 127(1-3), 230-240.
29. Nagasawa, M., Ogino, Y., Kurata, K., et al. (2012). Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats. Amino Acids. doi: 10. 1007/s00726-012-1294-y.
30. Ni, Y., Su, M., Lin, J., et al. (2008). Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Letters, 582(17), 2627-2636.
31. Nicholson, J. K., & Wilson, I. D. (2003). Opinion: Understanding 'global' systems biology: Metabonomics and the continuum of metabolism. Nature Reviews Drug Discovery, 2(8), 668-676.
32. Nofzinger, E. A., Buysse, D. J., Germain, A., et al. (2005). Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression. Archives of General Psychiatry, 62(4), 387-396.
33. Paige, L. A., Mitchell, M. W., Krishnan, K. R., Kaddurah-Daouk, R., & Steffens, D. C. (2007). A preliminary metabolomic analysis of older adults with and without depression. International Journal of Geriatric Psychiatry, 22(5), 418-423.
34. Pariante, C. M., & Lightman, S. L. (2008). The HPA axis in major depression: Classical theories and new developments. Trends in Neurosciences, 31(9), 464-468.
35. Pavlik, A., & Buresova, M. (1984). The neonatal cerebellum: The highest level of glucocorticoid receptors in the brain. Brain Research, 314(1), 13-20.
36. Porsolt, R. D., Le Pichon, M., & Jalfre, M. (1977). Depression: A new animal model sensitive to antidepressant treatments. Nature, 266(5604), 730-732.
37. Rothman, D. L., Behar, K. L., Hyder, F., & Shulman, R. G. (2003). In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: Implications for brain function. Annual Review of Physiology, 65, 401-427.
38. Sanchez, M. M., Young, L. J., Plotsky, P. M., & Insel, T. R. (2000). Distribution of corticosteroid receptors in the rhesus brain: Relative absence of glucocorticoid receptors in the hippocampal formation. The Journal of Neuroscience, 20(12), 4657-4668.
39. Shah, S. A., Doraiswamy, P. M., Husain, M. M., et al. (1992). Posterior fossa abnormalities in major depression: A controlled magnetic resonance imaging study. Acta Psychiatrica Scandinavica, 85(6), 474-479.
40. Smriga, M., Kameishi, M., Uneyama, H., & Torii, K. (2002). Dietary l-lysine deficiency increases stress-induced anxiety and fecal excretion in rats. The Journal of Nutrition, 132(12), 3744-3746.
41. Smriga, M., Ghosh, S., Mouneimne, Y., Pellett, P. L., & Scrimshaw, N. S. (2004). Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria. Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8285-8288.
42. Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005). The psychobiology of depression and resilience to stress: Implications for prevention and treatment. Annual Review of Clinical Psychology, 1, 255-291.
43. Strekalova, T., Spanagel, R., Bartsch, D., Henn, F. A., & Gass, P. (2004). Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology, 29(11), 2007-2017.
44. Su, Z. H., Li, S. Q., Zou, G. A., et al. (2011). Urinary metabonomics study of anti-depressive effect of Chaihu-Shu-Gan-San on an experimental model of depression induced by chronic variable stress in rats. Journal of Pharmaceutical and Biomedical Analysis, 55(3), 533-539.
45. Sweeney, J. A., Strojwas, M. H., Mann, J. J., & Thase, M. E. (1998). Prefrontal and cerebellar abnormalities in major depression: Evidence from oculomotor studies. Biological Psychiatry, 43(8), 584-594.
46. Takagi, T., Ando, R., Ohgushi, A., et al. (2001). Intracerebroventricular injection of pipecolic acid inhibits food intake and induces sleeping-like behaviors in the neonatal chick. Neuroscience Letters, 310(2-3), 97-100.
47. Taliaz, D., Loya, A., Gersner, R., Haramati, S., Chen, A., & Zangen, A. (2011). Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor. The Journal of Neuroscience, 31(12), 4475-4483.
48. Teague, C. R., Dhabhar, F. S., Barton, R. H., et al. (2007). Metabonomic studies on the physiological effects of acute and chronic psychological stress in Sprague-Dawley rats. Journal of Proteome Research, 6(6), 2080-2093.
49. Trygg, J., & Wold, S. (2002). Orthogonal projections to latent structures (O-PLS). Journal of Chemometrics, 16(3), 119-128.
50. Walter, M., Henning, A., Grimm, S., et al. (2009). The relationship between aberrant neuronal activation in the pregenual anteriorcingulate, altered glutamatergic metabolism, and anhedonia in major depression. Archives of General Psychiatry, 66(5), 478-486.
51. Wang, X., Zhao, T., Qiu, Y., et al. (2009). Metabonomics approach to understanding acute and chronic stress in rat models. Journal of Proteome Research, 8(5), 2511-2518.
52. Willner, P. (2005). Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology, 52(2), 90-110.
53. Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987). Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl), 93(3), 358-364.
54. Zhang, F., Jia, Z., Gao, P., et al. (2010). Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry. Molecular BioSystems, 6(5), 852-861.
55. Zheng, P., Gao, H. C., Li, Q., et al. (2012). Plasma metabonomics as a novel diagnostic approach for major depressive disorder. Journal of Proteome Research, 11(3), 1741-1748.
56. Zheng, S., Yu, M., Lu, X., et al. (2010). Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression. Clinica Chimica Acta, 411(3-4), 204-209.
57. 1H NMR and UPLC-MS-based plasma metabonomic study to investigate the biochemical changes in chronic unpredictable mild stress model of depression. Metabolomics, 7, 413-423.