Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1h-mrs

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Xi, Guangjun ^a   Hui, Jiaojie ^a   Zhang, Zhijun ^a   Liu, Shanshan ^a   Zhang, Xiangrong ^a   Teng, Gaojun ^a   Chan, Kevin C ^b   Wu, Ed X ^b   Nie, Binbin ^c   Shan, Baoci ^c   Li, Lingjiang ^d   Reynolds, Gavin P ^e  

^a SOUTHEAST UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

^e SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESCITALOPRAM; N ACETYLASPARTIC ACID; ASPARTIC ACID; CITALOPRAM; CREATINE; DRUG DERIVATIVE; N-ACETYLASPARTATE; PROTON; SUCROSE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; BRAIN SIZE; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DRUG EFFECT; HIPPOCAMPUS; LEARNING; MALE; MEMORY; MENTAL PERFORMANCE; NEUROCHEMISTRY; NEUROIMAGING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; DRINKING BEHAVIOR; MAZE TEST; MENTAL STRESS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ASPARTIC ACID; BEHAVIOR, ANIMAL; CITALOPRAM; CREATINE; DEPRESSION; DISEASE MODELS, ANIMAL; DRINKING BEHAVIOR; HIPPOCAMPUS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MAZE LEARNING; MEMORY; ORGAN SIZE; PROTONS; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL; SUCROSE; WATER;

EID: 83355172820     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028686     Document Type: Article

References (58)

1. Wong ML, Licinio J, (2001) Research and treatment approaches to depression. Nat Rev Neurosci 2: 343-351.
2. Dolan RJ, (2002) Emotion, cognition, and behavior. Science 298: 1191-1194.
3. Kuzis G, Sabe L, Tiberti C, Leiguarda R, Starkstein SE, et al. (1997) Cognitive functions in major depression and Parkinson disease. Arch Neurol 54: 982-986.
4. Ravnkilde B, Videbech P, Clemmensen K, Egander A, Rasmussen NA, et al. (2002) Cognitive deficits in major depression. Scand J Psychol 43: 239-251.
5. Song L, Che W, Min-Wei W, Murakami Y, Matsumoto K, et al. (2006) Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 83: 186-193.
6. Sun MK, Alkon DL, (2004) Induced depressive behavior impairs learning and memory in rats. Neuroscience 129: 129-139.
7. Duman RS, Malberg J, Nakagawa S, D SC, (2000) Neuronal plasticity and survival in mood disorders. Biol Psychiatry 48: 732-739.
8. Alfarez DN, Joels M, Krugers HJ, (2003) Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro. Eur J Neurosci 17: 1928-1934.
9. Pavlides C, Nivon LG, McEwen BS, (2002) Effects of chronic stress on hippocampal long-term potentiation. Hippocampus 12: 245-257.
10. Dranovsky A, Hen R, (2006) Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry 59: 1136-1143.
11. Campbell S, Macqueen G, (2004) The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci 29: 417-426.
12. Eichenbaum H, (2004) Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron 44: 109-120.
13. Olton DS, Papas BC, (1979) Spatial memory and hippocampal function. Neuropsychologia 17: 669-682.
14. Eichenbaum H, (2001) The hippocampus and declarative memory: cognitive mechanisms and neural codes. Behav Brain Res 127: 199-207.
15. Eichenbaum H, (1999) The hippocampus and mechanisms of declarative memory. Behav Brain Res 103: 123-133.
16. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R, et al. (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 93: 358-364.
17. Willner P, (1997) Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 134: 319-329.
18. Willner P, Muscat R, Papp M, (1992) Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev 16: 525-534.
19. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (4th ed) Washington, DC.
20. Zheng H, Liu Y, Li W, Yang B, Chen D, et al. (2006) Beneficial effects of exercise and its molecular mechanisms on depression in rats. Behav Brain Res 168: 47-55.
21. Gouirand AM, Matuszewich L, (2005) The effects of chronic unpredictable stress on male rats in the water maze. Physiol Behav 86: 21-31.
22. Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hanicke W, et al. (1989) Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors. Radiology 172: 541-548.
23. Pfeuffer J, Dreher W, Sykova E, Leibfritz D, (1998) Water signal attenuation in diffusion-weighted 1H NMR experiments during cerebral ischemia: influence of intracellular restrictions, extracellular tortuosity, and exchange. Magn Reson Imaging 16: 1023-1032.
24. Tkac I, Henry PG, Andersen P, Keene CD, Low WC, et al. (2004) Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T. Magn Reson Med 52: 478-484.
25. Zakzanis KK, Leach L, Kaplan E, (1998) On the nature and pattern of neurocognitive function in major depressive disorder. Neuropsychiatry Neuropsychol Behav Neurol 11: 111-119.
26. Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Chui DH, et al. (2000) Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. J Neurosci 20: 1568-1574.
27. Haaga DA, Beck AT, (1995) Perspectives on depressive realism: implications for cognitive theory of depression. Behav Res Ther 33: 41-48.
28. Fann JR, Uomoto JM, Katon WJ, (2001) Cognitive improvement with treatment of depression following mild traumatic brain injury. Psychosomatics 42: 48-54.
29. Harmer CJ, Bhagwagar Z, Cowen PJ, Goodwin GM, (2002) Acute administration of citalopram facilitates memory consolidation in healthy volunteers. Psychopharmacology (Berl) 163: 106-110.
30. Meneses A, (2002) Tianeptine: 5-HT uptake sites and 5-HT(1-7) receptors modulate memory formation in an autoshaping Pavlovian/instrumental task. Neurosci Biobehav Rev 26: 309-319.
31. Nowakowska E, Kus K, Chodera A, Rybakowski J, (2001) Investigating potential anxiolytic, antidepressant and memory enhancing activity of deprenyl. J Physiol Pharmacol 52: 863-873.
32. Yau JL, Noble J, Hibberd C, Rowe WB, Meaney MJ, et al. (2002) Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats. J Neurosci 22: 1436-1442.
33. Yildiz-Yesiloglu A, Ankerst DP, (2006) Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Res 147: 1-25.
34. Czeh B, Michaelis T, Watanabe T, Frahm J, de BG, et al. (2001) Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 98: 12796-12801.
35. McEwen BS, Sapolsky RM, (1995) Stress and cognitive function. Curr Opin Neurobiol 5: 205-216.
36. Crochemore C, Michaelidis TM, Fischer D, Loeffler JP, Almeida OF, et al. (2002) Enhancement of p53 activity and inhibition of neural cell proliferation by glucocorticoid receptor activation. FASEB J 16: 761-770.
37. Crochemore C, Lu J, Wu Y, Liposits Z, Sousa N, et al. (2005) Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry 10: 790-798.
38. Watanabe Y, Gould E, McEwen BS, (1992) Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588: 341-345.
39. Magarinos AM, Verdugo JM, McEwen BS, (1997) Chronic stress alters synaptic terminal structure in hippocampus. Proc Natl Acad Sci U S A 94: 14002-14008.
40. Sousa N, Lukoyanov NV, Madeira MD, Almeida OF, Paula-Barbosa MM, et al. (2000) Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience 97: 253-266.
41. Xi G, Zhang X, Zhang L, Sui Y, Hui J, et al. (2011) Fluoxetine attenuates the inhibitory effect of glucocorticoid hormones on neurogenesis in vitro via a two-pore domain potassium channel, TREK-1. Psychopharmacology (Berl) 214: 747-759.
42. Sairanen M, O LO, Knuuttila JE, Castren E, (2007) Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat. Neuroscience 144: 368-374.
43. Zusso M, Debetto P, Guidolin D, Barbierato M, Manev H, et al. (2008) Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum. Biochem Pharmacol 76: 391-403.
44. Chiou SH, Chen SJ, Peng CH, Chang YL, Ku HH, et al. (2006) Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell. Biochem Biophys Res Commun 343: 391-400.
45. Schuff N, Neylan TC, Lenoci MA, Du AT, Weiss DS, et al. (2001) Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry 50: 952-959.
46. Didic M, Ranjeva JP, Barbeau E, Confort-Gouny S, Fur YL, et al. (2010) Impaired visual recognition memory in amnestic mild cognitive impairment is associated with mesiotemporal metabolic changes on magnetic resonance spectroscopic imaging. J Alzheimers Dis 22: 1269-1279.
47. Premkumar P, Parbhakar VA, Fannon D, Lythgoe D, Williams SC, et al. (2010) N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: a study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects. Psychiatry Res 182: 251-260.
48. Mantoan MA, Caboclo LO, de FF, Lin K, da SN, et al. (2009) Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis. Epilepsy Behav 16: 447-453.
49. Pilatus U, Lais C, Rochmont AM, Kratzsch T, Frolich L, et al. (2009) Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy. Psychiatry Res 173: 1-7.
50. Zimmerman ME, Pan JW, Hetherington HP, Katz MJ, Verghese J, et al. (2008) Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults. Neurology 70: 1594-1600.
51. Block W, Traber F, von WO, Metten M, Schild H, et al. (2009) Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response. Int J Neuropsychopharmacol 12: 415-422.
52. Nie B, Hui J, Wang L, Chai P, Gao J, et al. (2010) Automatic method for tracing regions of interest in rat brain magnetic resonance imaging studies. J Magn Reson Imaging 32: 830-835.
53. Hui J, Zhang Z, Liu S, Xi G, Zhang X, et al. (2010) Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats. Eur Neuropsychopharmacol 20: 875-883.
54. Hui JJ, Zhang ZJ, Liu SS, Xi GJ, Zhang XR, et al. (2011) Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: a magnetic resonance study. Behav Brain Res 217: 122-127.
55. D AP, Newton J, Willner P, (1997) Diurnal variation in the effect of chronic mild stress on sucrose intake and preference. Physiol Behav 62: 421-426.
56. Porsolt RD, Le PM, Jalfre M, (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266: 730-732.
57. Chan KC, Khong PL, Cheung MM, Wang S, Cai KX, et al. (2009) MRI of late microstructural and metabolic alterations in radiation-induced brain injuries. J Magn Reson Imaging 29: 1013-1020.
58. Chan KC, So KF, Wu EX, (2009) Proton magnetic resonance spectroscopy revealed choline reduction in the visual cortex in an experimental model of chronic glaucoma. Exp Eye Res 88: 65-70.