Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 96-105

  Sosanya, Natasha M ^a   Brager, Darrin H ^a   Wolfe, Sarah ^a   Niere, Farr ^a   Raab Graham, Kimberly F ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

MiRNA; MTOR; Potassium channels; Rapamycin; Temporal lobe epilepsy

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MICRORNA; MICRORNA 129 5P; POTASSIUM CHANNEL KV1.1; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR STIMULATING AGENT; HU ANTIGEN; KAINIC ACID; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EPILEPTIC STATE; EPILEPTOGENESIS; MALE; MOLECULAR PATHOLOGY; NERVE CELL EXCITABILITY; NERVE POTENTIAL; NONHUMAN; POTASSIUM CHANNEL KV1.1 GENE; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; RNA TRANSLATION; TRANSLATION REGULATION; ACTION POTENTIAL; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; IN VITRO STUDY; METABOLISM; PATCH CLAMP TECHNIQUE; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STATUS EPILEPTICUS; SYNAPTIC TRANSMISSION; TIME;

ACTION POTENTIALS; ANIMALS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGONISTS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; IN VITRO TECHNIQUES; KAINIC ACID; KV1.1 POTASSIUM CHANNEL; MALE; MICRORNAS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; STATUS EPILEPTICUS; SYNAPTIC TRANSMISSION; TIME FACTORS; TOR SERINE-THREONINE KINASES;

EID: 84908428481     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.09.011     Document Type: Article

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