-
1
-
-
33645851658
-
Refractory epilepsy: Mechanisms and solutions
-
Kwan P, Brodie MJ. Refractory epilepsy: Mechanisms and solutions. Expert Rev. Neurother. 6, 397-406 (2006
-
(2006)
Expert Rev. Neurother.
, vol.6
, pp. 397-406
-
-
Kwan, P.1
Brodie, M.J.2
-
2
-
-
0035048478
-
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: Meta-analysis of controlled trials
-
DOI 10.1046/j.1528-1157.2001.28900.x
-
Temkin NR. Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: Meta-analysis of controlled trials. Epilepsia 42, 515-524 (2001 (Pubitemid 32322197)
-
(2001)
Epilepsia
, vol.42
, Issue.4
, pp. 515-524
-
-
Temkin, N.R.1
-
3
-
-
78751488401
-
Mechanisms of epileptogenesis and potential treatment targets
-
Pitkanen A, Lukasiuk K. Mechanisms of epileptogenesis and potential treatment targets. Lancet Neurol. 10, 173-186 (2011
-
(2011)
Lancet Neurol.
, vol.10
, Issue.173-186
-
-
Pitkanen, A.1
Lukasiuk, K.2
-
4
-
-
76249084241
-
Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
-
Wong M. Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia 51, 27-36 (2010
-
(2010)
Epilepsia
, vol.51
, pp. 27-36
-
-
Wong, M.1
-
5
-
-
79957864093
-
Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis
-
McDaniel SS, Wong M. Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis. Neurosci. Lett. 497, 231-239 (2011
-
(2011)
Neurosci. Lett.
, vol.497
, pp. 231-239
-
-
McDaniel, S.S.1
Wong, M.2
-
6
-
-
84863727156
-
Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target
-
Galanopoulou AS, Gorter JA, Cepeda C. Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target. Epilepsia 53(7), 1119-1130 (2012
-
(2012)
Epilepsia
, vol.53
, Issue.7
, pp. 1119-1130
-
-
Galanopoulou, A.S.1
Gorter, J.A.2
Cepeda, C.3
-
7
-
-
79958795394
-
Frontier of epilepsy research - mTOR signaling pathway
-
Cho CH. Frontier of epilepsy research - mTOR signaling pathway. Exp. Mol. Med. 43, 231-274 (2011
-
(2011)
Exp. Mol. Med.
, vol.43
, pp. 231-274
-
-
Cho, C.H.1
-
8
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R.,Efevan A.,Sabitini D.M. mTOR: From growth signal integration toZoncu R, Efevan A, Sabitini DM. mTOR: From growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell. Biol. 12, 21-35 (2011
-
(2011)
Nat. Rev. Mol. Cell. Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efevan, A.2
Sabitini, D.M.3
-
9
-
-
84856078168
-
Deconvoluting mTOR biology
-
Weber JD, Gutmann DH. Deconvoluting mTOR biology. Cell Cycle 11, 236-248 (2012
-
(2012)
Cell Cycle
, vol.11
, pp. 236-248
-
-
Weber, J.D.1
Gutmann, D.H.2
-
10
-
-
33646023695
-
Prolonged rapamycin treatment inhibitors mTORC2 assembly and Akt/PBK
-
Sarbassov DD, Ali SM, Sengupta S et al. Prolonged rapamycin treatment inhibitors mTORC2 assembly and Akt/PBK. Mol. Cell 22, 159-169 (2006
-
(2006)
Mol. Cell
, vol.22
, pp. 159-169
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
-
13
-
-
33644827461
-
Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
-
DOI 10.1002/ana.20784
-
Franz DN, Leonard J, Tudor C et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann. Neurol. 59, 490-498 (2006 (Pubitemid 43358069)
-
(2006)
Annals of Neurology
, vol.59
, Issue.3
, pp. 490-498
-
-
Franz, D.N.1
Leonard, J.2
Tudor, C.3
Chuck, G.4
Care, M.5
Sethuraman, G.6
Dinopoulos, A.7
Thomas, G.8
Crone, K.R.9
-
14
-
-
78049510428
-
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
-
Krueger DA, Care MM, Holland K et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N. Engl. J. Med. 363, 1801-1811 (2010
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1801-1811
-
-
Krueger, D.A.1
Care, M.M.2
Holland, K.3
-
15
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
-
Bissler JJ, McCormack FX, Young LR et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N. Engl. J. Med. 358, 140-151 (2008
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 140-151
-
-
Bissler, J.J.1
McCormack, F.X.2
Young, L.R.3
-
16
-
-
80052472675
-
Multicenter Phase 2 trial of sirolimus for tuberous sclerosis: Kidney angiomyolipomas and other tumors regress and VEGF-D levels decrease
-
Dabora SL, Franz DN, Ashwal S et al. Multicenter Phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF-D levels decrease. PLoS ONE 6, e23379 (2011
-
(2011)
PLoS ONE
, vol.6
-
-
Dabora, S.L.1
Franz, D.N.2
Ashwal, S.3
-
17
-
-
34247111348
-
Rapamycin: Brain excitability studied in vitro
-
DOI 10.1111/j.1528-1167.2006.00976.x
-
Daoud D, Scheld HH, Speckmann EJ, Gorji A. Rapamycin: brain excitability studied in vitro. Epilepsia 48, 834-836 (2007 (Pubitemid 46587621)
-
(2007)
Epilepsia
, vol.48
, Issue.4
, pp. 834-836
-
-
Daoud, D.1
Scheld, H.H.2
Speckmann, E.-J.3
Gorji, A.4
-
18
-
-
36249023723
-
Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
-
DOI 10.1016/j.eplepsyres.2007.09.009, PII S0920121107002513
-
Ruegg S, Baybis M, Juul H, Dichter M, Crino PB. Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons. Epilepsy Res. 77, 85-92 (2007 (Pubitemid 350137689)
-
(2007)
Epilepsy Research
, vol.77
, Issue.2-3
, pp. 85-92
-
-
Ruegg, S.1
Baybis, M.2
Juul, H.3
Dichter, M.4
Crino, P.B.5
-
19
-
-
33749639034
-
Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites
-
DOI 10.1126/science.1131693
-
Graham KF, Haddick PC, Jan YN, Jan LY. Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314, 144-148 (2006 (Pubitemid 44547761)
-
(2006)
Science
, vol.314
, Issue.5796
, pp. 144-148
-
-
Raab-Graham, K.F.1
Haddick, P.C.G.2
Jan, Y.N.3
Jan, L.Y.4
-
20
-
-
33646391271
-
A role for the mTOR pathway in surface expression of AMPA receptors
-
Wang Y, Barbaro MF, Baraban SC. A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci. Lett. 401, 35-39 (2006
-
(2006)
Neurosci. Lett.
, vol.401
, pp. 35-39
-
-
Wang, Y.1
Barbaro, M.F.2
Baraban, S.C.3
-
21
-
-
42949140259
-
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
-
DOI 10.1002/ana.21331
-
Zeng L, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann. Neurol. 63, 444-453 (2008 (Pubitemid 351614710)
-
(2008)
Annals of Neurology
, vol.63
, Issue.4
, pp. 444-453
-
-
Zeng, L.-H.1
Xu, L.2
Gutmann, D.H.3
Wong, M.4
-
22
-
-
0242268407
-
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
-
DOI 10.1073/pnas.2132711100
-
Kwon C, Zhu X, Zhang J, Baker SJ. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc. Natl Acad. Sci. USA 100, 12923-12928 (2003 (Pubitemid 37340001)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.22
, pp. 12923-12928
-
-
Kwon, C.-H.1
Zhu, X.2
Zhang, J.3
Baker, S.J.4
-
23
-
-
68349100270
-
Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
-
Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis. Model. Mech. 2, 389-398 (2009
-
(2009)
Dis. Model. Mech.
, vol.2
, pp. 389-398
-
-
Ljungberg, M.C.1
Sunnen, C.N.2
Lugo, J.N.3
Anderson, A.E.4
D'Arcangelo, G.5
-
24
-
-
80155189536
-
Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
-
Sunnen CN, Brewster AL, Lugo JN et al. Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice. Epilepsia 52, 2065-2075 (2011
-
(2011)
Epilepsia
, vol.52
, pp. 2065-2075
-
-
Sunnen, C.N.1
Brewster, A.L.2
Lugo, J.N.3
-
25
-
-
60849109211
-
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
-
Zhou J, Blundell J, Ogawa S et al. Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J. Neurosci. 29, 1773-1783 (2009
-
(2009)
J. Neurosci.
, vol.29
, pp. 1773-1783
-
-
Zhou, J.1
Blundell, J.2
Ogawa, S.3
-
26
-
-
64249118425
-
Rapamycin reduces seizure frequency in tuberous sclerosis complex
-
Muncy J, Butler IJ, Koenig M. Rapamycin reduces seizure frequency in tuberous sclerosis complex. J. Child Neurol. 24, 477 (2009
-
(2009)
J. Child Neurol.
, vol.24
, pp. 477
-
-
Muncy, J.1
Butler, I.J.2
Koenig, M.3
-
27
-
-
84655166921
-
Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex
-
Perek-Poinik M, Jozwiak S, Jurkiewicz E, Perek D, Kotulska K. Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex. Eur. J. Paediatr. Neurol. 16, 83-85 (2012
-
(2012)
Eur. J. Paediatr. Neurol.
, vol.16
, pp. 83-85
-
-
Perek-Poinik, M.1
Jozwiak, S.2
Jurkiewicz, E.3
Perek, D.4
Kotulska, K.5
-
29
-
-
77955845741
-
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
-
Huang X, Zhang H, Yang J et al. Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy. Neurobiol. Dis. 40, 193-199 (2010
-
(2010)
Neurobiol. Dis.
, vol.40
, pp. 193-199
-
-
Huang, X.1
Zhang, H.2
Yang, J.3
-
30
-
-
79958184395
-
A pulse rapamycin therapy for infantile spasms and associated cognitive decline
-
Raffo E, Coppola A, Ono T, Briggs SW, Galanopoulo AS. A pulse rapamycin therapy for infantile spasms and associated cognitive decline. Neurobiol. Dis. 43, 322-328 (2011
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 322-328
-
-
Raffo, E.1
Coppola, A.2
Ono, T.3
Briggs, S.W.4
Galanopoulo, A.S.5
-
31
-
-
84866325732
-
Rapamycin has anticonvulsant effects in acute seizure tests
-
Hartman A, Santos P, Hardwick JM. Rapamycin has anticonvulsant effects in acute seizure tests. Epilepsy Curr. 12 (Suppl. 1), S104 (2012
-
(2012)
Epilepsy Curr.
, vol.12
, Issue.SUPPL. 1
-
-
Hartman, A.1
Santos, P.2
Hardwick, J.M.3
-
32
-
-
84864000749
-
Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats
-
Huang X, McMahon J, Yang J, Shin D, Huang Y. Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. Neuroscience 219, 33-47 (2012
-
(2012)
Neuroscience
, vol.219
, pp. 33-47
-
-
Huang, X.1
McMahon, J.2
Yang, J.3
Shin, D.4
Huang, Y.5
-
33
-
-
45849110311
-
Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function
-
Meikle L, Pollizzi K, Egnor A et al. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function. J. Neurosci. 28, 5422-5432 (2008
-
(2008)
J. Neurosci.
, vol.28
, pp. 5422-5432
-
-
Meikle, L.1
Pollizzi, K.2
Egnor, A.3
-
34
-
-
81055126193
-
Regulable neural progenitor-specific TSC1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
-
Goto J, Talos DM, Klein P et al. Regulable neural progenitor-specific TSC1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc. Natl Acad. Sci. USA 108, 1070-1079 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 1070-1079
-
-
Goto, J.1
Talos, D.M.2
Klein, P.3
-
35
-
-
78651064535
-
TSC2 gene inactivation causes a more severe epilepsy phenotype than TSC1 inactivation in a mouse model of tuberous sclerosis complex
-
Zeng L, Rensing NR, Zhang B, Gutmann DH, Gambello MJ, Wong M. TSC2 gene inactivation causes a more severe epilepsy phenotype than TSC1 inactivation in a mouse model of tuberous sclerosis complex. Hum. Mol. Genet. 20, 445-454 (2011
-
(2011)
Hum Mol Genet.
, vol.20
, pp. 445-454
-
-
Zeng, L.1
Rensing, N.R.2
Zhang, B.3
Gutmann, D.H.4
Gambello, M.J.5
Wong, M.6
-
36
-
-
81955164876
-
Neuronal and glia abnormalities in TSC1-deficient forebrain and partial rescue by rapamycin
-
Carson RP, Van Nielen DL, Winzenburger PA, Ess KC. Neuronal and glia abnormalities in TSC1-deficient forebrain and partial rescue by rapamycin. Neurobiol. Dis. 45, 369-380 (2012
-
(2012)
Neurobiol. Dis.
, vol.45
, pp. 369-380
-
-
Carson, R.P.1
Van Nielen, D.L.2
Winzenburger, P.A.3
Ess, K.C.4
-
37
-
-
67649382228
-
Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
-
Buckmaster PS, Ingram EA, Wen X. Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J. Neurosci. 29, 8259-8269 (2009
-
(2009)
J. Neurosci.
, vol.29
, pp. 8259-8269
-
-
Buckmaster, P.S.1
Ingram, E.A.2
Wen, X.3
-
38
-
-
84862797771
-
Rapamycin suppresses the recurrent excitatory circuits of dentate gyrus in a mouse model of temporal lobe epilepsy
-
Tang H, Long H, Zeng C et al. Rapamycin suppresses the recurrent excitatory circuits of dentate gyrus in a mouse model of temporal lobe epilepsy. Biochem. Biophys. Res. Commun. 420, 199-204 (2012
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.420
, pp. 199-204
-
-
Tang, H.1
Long, H.2
Zeng, C.3
-
39
-
-
66149169973
-
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
-
Zeng LH, Rensing NR, Wong M. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J. Neurosci. 29, 6964-6972 (2009
-
(2009)
J. Neurosci.
, vol.29
, pp. 6964-6972
-
-
Zeng, L.H.1
Rensing, N.R.2
Wong, M.3
-
40
-
-
84863718111
-
Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation
-
van Vliet EA, Forte G, Holtman L et al. Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Epilepsia 53(7),1254-1263 (2012
-
(2012)
Epilepsia
, vol.53
, Issue.7
, pp. 1254-1263
-
-
Van Vliet, E.A.1
Forte, G.2
Holtman, L.3
-
41
-
-
33947219280
-
Rapamycin is a neuroprotective treatment for traumatic brain injury
-
DOI 10.1016/j.nbd.2006.12.003, PII S0969996106003123
-
Erlich S, Alexandrovich A, Shohami E, Pinkas-Kramarski R. Rapamycin is a neuroprotective treatment for traumatic brain injury. Neurobiol. Dis. 26, 86-93 (2007 (Pubitemid 46436489)
-
(2007)
Neurobiology of Disease
, vol.26
, Issue.1
, pp. 86-93
-
-
Erlich, S.1
Alexandrovich, A.2
Shohami, E.3
Pinkas-Kramarski, R.4
-
42
-
-
84860491069
-
The interaction between early life epilepsy and autistic-like behavioral consequences: A role for the mammalian target of rapamycin (mTORC1) pathway
-
Talos DM, Sun H, Zhou X et al. The interaction between early life epilepsy and autistic-like behavioral consequences: A role for the mammalian target of rapamycin (mTORC1) pathway. PLoS ONE 7, e35885 (2012
-
(2012)
PLoS ONE
, vol.7
-
-
Talos, D.M.1
Sun, H.2
Zhou, X.3
-
43
-
-
84861818199
-
Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy
-
Huang X, McMahon J, Huang Y. Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy. Neuroscience 215, 90-97 (2012
-
(2012)
Neuroscience
, vol.215
, pp. 90-97
-
-
Huang, X.1
McMahon, J.2
Huang, Y.3
-
44
-
-
79951531485
-
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
-
Buckmaster PS, Lew FH. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J. Neurosci. 31, 2337-2347 (2011
-
(2011)
J. Neurosci.
, vol.31
, pp. 2337-2347
-
-
Buckmaster, P.S.1
Lew, F.H.2
-
45
-
-
84856372774
-
Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
-
Sliwa A, Plucinska G, Bednarczyk J, Lukasiuk K. Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. Neurosci. Lett. 509(2), 105-109 (2012
-
(2012)
Neurosci. Lett.
, vol.509
, Issue.2
, pp. 105-109
-
-
Sliwa, A.1
Plucinska, G.2
Bednarczyk, J.3
Lukasiuk, K.4
-
46
-
-
80052550273
-
Validation of the rat model of cryptogenic infantile spasms
-
Chachua T, Yum MS, Veliskova J, Velisek L. Validation of the rat model of cryptogenic infantile spasms. Epilepsia 52, 1666-1677 (2011
-
(2011)
Epilepsia
, vol.52
, pp. 1666-1677
-
-
Chachua, T.1
Yum, M.S.2
Veliskova, J.3
Velisek, L.4
-
47
-
-
82955237442
-
Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy?
-
Lew FH, Buckmaster PS. Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy? Epilepsia 52, 2326-2332 (2011
-
(2011)
Epilepsia
, vol.52
, pp. 2326-2332
-
-
Lew, F.H.1
Buckmaster, P.S.2
-
48
-
-
84861391406
-
The mTOR pathway is activated in glial cells in mesial temporal sclerosis
-
Sosunov AA, Wu X, McGovern RA et al. The mTOR pathway is activated in glial cells in mesial temporal sclerosis. Epilepsia 53(Suppl. 1), S78-S86 (2012
-
(2012)
Epilepsia 53(Suppl. 1
-
-
Sosunov, A.A.1
Wu, X.2
McGovern, R.A.3
-
49
-
-
39049083046
-
Clinical presentation and diagnosis of tuberous sclerosis complex in infancy
-
DOI 10.1177/0883073807309250
-
Datta AN, Hahn CD, Sahin M. Clinical presentation and diagnosis of tuberous sclerosis complex in infancy. J. Child Neurol. 23, 268-273 (2008 (Pubitemid 351247618)
-
(2008)
Journal of Child Neurology
, vol.23
, Issue.3
, pp. 268-273
-
-
Datta, A.N.1
Hahn, C.D.2
Sahin, M.3
-
50
-
-
77954529084
-
The natural history of epilepsy in tuberous sclerosis complex
-
Chu-Shore CJ, Major P, Camposano S, Muzykewicz D, Thiele EA. The natural history of epilepsy in tuberous sclerosis complex. Epilepsia 51, 1236-1241 (2010
-
(2010)
Epilepsia
, vol.51
, pp. 1236-1241
-
-
Chu-Shore, C.J.1
Major, P.2
Camposano, S.3
Muzykewicz, D.4
Thiele, E.A.5
-
51
-
-
33847038824
-
The growing role of mTOR in neuronal development and plasticity
-
Jaworski J, Sheng M. The growing role of mTOR in neuronal development and plasticity. Mol. Neurobiol. 34, 205-219 (2012
-
(2012)
Mol. Neurobiol.
, vol.34
, pp. 205-219
-
-
Jaworski, J.1
Sheng, M.2
-
52
-
-
9144233506
-
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells
-
DOI 10.1158/0008-5472.CAN-3554-2
-
Boulay A, Zumstein-Mecker S, Stephan C et al. Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res. 64, 252-261 (2004 (Pubitemid 38114106)
-
(2004)
Cancer Research
, vol.64
, Issue.1
, pp. 252-261
-
-
Boulay, A.1
Zumstein-Mecker, S.2
Stephan, C.3
Beuvink, I.4
Zilbermann, F.5
Haller, R.6
Tobler, S.7
Heusser, C.8
O'Reilly, T.9
Stolz, B.10
Marti, A.11
Thomas, G.12
Lane, H.A.13
-
53
-
-
77949478751
-
Comparison of three rapamycin dosing schedules in A/J Tsc2+/-mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors
-
Woodrum C, Nobil A, Dabora SL. Comparison of three rapamycin dosing schedules in A/J Tsc2+/-mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors. J. Transl. Med. 8, 14 (2010
-
(2010)
J. Transl. Med.
, vol.8
, pp. 14
-
-
Woodrum, C.1
Nobil, A.2
Dabora, S.L.3
-
54
-
-
79958698108
-
Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens
-
Rivera VM, Squillace RM, Miller D et al. Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Mol. Cancer Ther. 10, 1059-1071 (2011
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1059-1071
-
-
Rivera, V.M.1
Squillace, R.M.2
Miller, D.3
-
56
-
-
79951529849
-
Mammalian target of rapamycin: Hitting the bull's-eye for neurological disorders
-
Chong ZZ, Shang YC, Zhang L, Wang S, Maiese K. Mammalian target of rapamycin: Hitting the bull's-eye for neurological disorders. Oxid. Med. Cell Longev. 3, 374-391 (2010
-
(2010)
Oxid. Med. Cell Longev.
, vol.3
, pp. 374-391
-
-
Chong, Z.Z.1
Shang, Y.C.2
Zhang, L.3
Wang, S.4
Maiese, K.5
-
57
-
-
79960635284
-
Fighting neurodegeneration with rapamycin: Mechanistic insights
-
Bove J, Martinez-Vicente M, Vila M. Fighting neurodegeneration with rapamycin: Mechanistic insights. Nat. Rev. Neurosci. 12, 437-452 (2011
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 437-452
-
-
Bove, J.1
Martinez-Vicente, M.2
Vila, M.3
-
58
-
-
84865630995
-
Mammalian target of rapamycin (mTOR) inhibition: Potential for antiseizure, antiepileptogenic, and epileptostatic therapy
-
Ryther CC & Wong M. Mammalian target of rapamycin (mTOR) inhibition: Potential for antiseizure, antiepileptogenic, and epileptostatic therapy. Curr. Neurol. Neurosci. Rep. 12(4), 410-418 (2012
-
(2012)
Curr. Neurol. Neurosci. Rep.
, vol.12
, Issue.4
, pp. 410-418
-
-
Ryther, C.C.1
Wong, M.2
|