Evidence linking HHV-6 with multiple sclerosis: An update

Current Opinion in Virology

Volumn 9, Issue , 2014, Pages 127-133

  Leibovitch, Emily C ^a,b   Jacobson, Steven ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BETA INTERFERON; IMMUNOGLOBULIN M; INTERFERON REGULATORY FACTOR 5; MYELIN; VIRUS ANTIBODY; VIRUS DNA;

ARTICLE; ASTROCYTOSIS; B LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; CONSENSUS; CYTOMEGALOVIRUS; DISEASE COURSE; DRUG EFFICACY; EPSTEIN BARR VIRUS; GENOTYPE ENVIRONMENT INTERACTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN HERPESVIRUS 6; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; T LYMPHOCYTE; VIRUS DETECTION; VIRUS PATHOGENESIS; IMMUNOLOGY; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

CENTRAL NERVOUS SYSTEM; HERPESVIRUS 6, HUMAN; HUMANS; MULTIPLE SCLEROSIS;

EID: 84908413606     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2014.09.016     Document Type: Review

References (52)

1. J. Kesselring History of multiple sclerosis C.S. Raine, H.F. McFarland, R. Hohlfeld, Multiple Sclerosis: A Comprehensive Text 2008 Elsevier Saunders 474
2. P. Sola Human herpesvirus 6 and multiple sclerosis: survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction J Neurol Neurosurg Psychiatry 56 1993 917 919
3. F. Wilborn A potential role for human herpesvirus type 6 in nervous system disease J Neuroimmunol 49 1994 213 214
4. P.B. Challoner Plaque-associated expression of human herpesvirus 6 in multiple sclerosis Proc Natl Acad Sci U S A 92 1995 7440 7444
5. A. Venkatesan, and R.T. Johnson Infections and multiple sclerosis D.S. Goodin, Handbook of Clinical Neurology 2014 Elsevier B.V.
6. H.L. Lipton A specific viral cause of multiple sclerosis: one virus, one disease Ann Neurol 61 2007 514 523
7. R.M. Lucas Epstein-Barr virus and multiple sclerosis J Neurol Neurosurg Psychiatry 82 2011 1142 1148
8. J. Pakpoor, G. Giovannoni, and S.V. Ramagopalan Epstein-Barr virus and multiple sclerosis: association or causation? Expert Rev Neurother 13 2013 287 297
9. E. Merelli Human herpes virus 6 and human herpes virus 8 DNA sequences in brains of multiple sclerosis patients, normal adults and children J Neurol 244 1997 450 454
10. L. Gordon, S. McQuaid, and S.L. Cosby Detection of herpes simplex virus (types 1 and 2) and human herpesvirus 6 DNA in human brain tissue by polymerase chain reaction Clin Diagn Virol 6 1996 33 40
11. W. Liedtke Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis J Neurovirol 1 1995 253 258
12. M.L. Opsahl, and P.G. Kennedy Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter Brain 128 2005 516 527
13. V.J. Sanders Detection of herpesviridae in postmortem multiple sclerosis brain tissue and controls by polymerase chain reaction J Neurovirol 2 1996 249 258
14. C. Cermelli High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection J Infect Dis 187 2003 1377 1387
15. T. Derfuss, R. Hohlfeld, and E. Meinl Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B-cell response J Neurol 252 2005 968 971
16. J.O. Virtanen Intrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating diseases presenting as oligoclonal bands in cerebrospinal fluid J Neuroimmunol 237 2011 93 97
17. J. Pietilainen-Nicklen HHV-6-positivity in diseases with demyelination J Clin Virol 2014
18. D.H. Gilden Infectious causes of multiple sclerosis Lancet Neurol 4 2005 195 202
19. J.L. Bennet, X. Yu, D.H. Gilden, M.P. Burgoon, and G.P. Owens Infectious agents and multiple sclerosis C.S. Raine, H.F. McFarland, R. Hohlfeld, Multiple Sclerosis: A Comprehensive Text 2008 Elsevier Saunders 480
20. J.O. Virtanen Oligoclonal bands in multiple sclerosis reactive against two herpesviruses and association with magnetic resonance imaging findings Mult Scler 20 2014 27 34
21. S.C. Wuest A complex role of herpes viruses in the disease process of multiple sclerosis PLOS ONE 9 2014 pe105434
22. S.S. Soldan Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA Nat Med 3 1997 1394 1397 [see comments]
23. R. Berti Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression J Neurovirol 8 2002 250 256
24. M. Khaki Evaluation of viral antibodies in Iranian multiple sclerosis patients Neurosciences (Riyadh) 16 2011 224 228
25. N. Ramroodi Monitoring of active human herpes virus 6 infection in Iranian patients with different subtypes of multiple sclerosis J Pathog 2013 2013 194932
26. A. Behzad-Behbahani Human herpesvirus-6 viral load and antibody titer in serum samples of patients with multiple sclerosis J Microbiol Immunol Infect 44 2011 247 251
27. S. Simpson Jr. Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple sclerosis Mult Scler 18 2012 799 806
28. I. Ortega-Madueno Anti-human herpesvirus 6A/B IgG correlates with relapses and progression in multiple sclerosis PLOS ONE 9 2014 pe104836
29. Z. Nora-Krukle Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis Medicina (Kaunas) 47 2011 527 531
30. H. Uno TNF-alpha as a useful predictor of human herpesvirus-6 reactivation and indicator of the disease process in drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) J Dermatol Sci 74 2014 177 179
31. N. Ben-Fredj Prevalence of human herpesvirus U94/REP antibodies and DNA in Tunisian multiple sclerosis patients J Neurovirol 19 2013 42 47
32. E. Caselli Detection of antibodies directed against human herpesvirus 6 U94/REP in sera of patients affected by multiple sclerosis J Clin Microbiol 40 2002 4131 4137
33. R. Alenda Identification of the major HHV-6 antigen recognized by cerebrospinal fluid IgG in multiple sclerosis Eur J Neurol 21 2014 1096 1101
34. S. Dhib-Jalbut, and S. Marks Interferon-beta mechanisms of action in multiple sclerosis Neurology 74 2010 S17 S24
35. M. Garcia-Montojo Human herpesvirus 6 and effectiveness of interferon beta1b in multiple sclerosis patients Eur J Neurol 18 2011 1027 1035
36. K. Vandenbroeck Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection Genes Immun 12 2011 40 45
37. M. Garcia-Montojo Herpesvirus active replication in multiple sclerosis: a genetic control? J Neurol Sci 311 2011 98 102
38. M.I. Dominguez-Mozo MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up BMC Neurol 12 2012 107
39. A.W. Lee Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels Mol Immunol 48 2011 1160 1167
40. B.M. Sullivan, and L. Coscoy The U24 protein from human herpesvirus 6 and 7 affects endocytic recycling J Virol 84 2010 1265 1275
41. M.V. Tejada-Simon Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis Ann Neurol 53 2003 189 197
42. W. Cheng Cross-reactivity of autoreactive T cells with MBP and viral antigens in patients with MS Front Biosci (Landmark Ed) 17 2012 1648 1658
43. G.M. Hon, R.T. Erasmus, and T. Matsha Low prevalence of human herpesvirus-6 and varicella zoster virus in blood of multiple sclerosis patients, irrespective of inflammatory status or disease progression J Clin Neurosci 21 2014 1437 1440
44. R. Gustafsson Incidence of human herpesvirus 6 in clinical samples from Swedish patients with demyelinating diseases J Microbiol Immunol Infect 2013
45. S. Simpson Jr. EBV & HHV6 reactivation is infrequent and not associated with MS clinical course Acta Neurol Scand 2014
46. D. Ablashi Classification of HHV-6A and HHV-6B as distinct viruses Arch Virol 159 2014 863 870
47. E.C. Leibovitch Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstrated by novel digital droplet PCR assay PLOS ONE 9 2014 pe92328
48. N. Akhyani Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis J Infect Dis 182 2000 1321 1325
49. Y. Higashimoto Development of a human herpesvirus 6 species-specific immunoblotting assay J Clin Microbiol 50 2012 1245 1251
50. S. Haahr A role of late Epstein-Barr virus infection in multiple sclerosis Acta Neurol Scand 109 2004 270 275
51. C. Yea Epstein-Barr virus in oral shedding of children with multiple sclerosis Neurology 81 2013 1392 1399
52. C.F. Ryschkewitsch, P.N. Jensen, and E.O. Major Multiplex qPCR assay for ultra sensitive detection of JCV DNA with simultaneous identification of genotypes that discriminates non-virulent from virulent variants J Clin Virol 57 2013 243 248