Detection of antibodies directed against human herpesvirus 6 U94/REP in sera of patients affected by multiple sclerosis

Journal of Clinical Microbiology

Volumn 40, Issue 11, 2002, Pages 4131-4137

  Caselli, Elisabetta ^a   Boni, Michela ^a   Bracci, Arianna ^a   Rotola, Antonella ^a   Cermelli, Claudio ^a   Castellazzi, Massimiliano ^a   Di Luca, Dario ^a   Cassai, Enzo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE U94; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; MALE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SEROLOGY; SERUM; VIRUS GENE; VIRUS LATENCY;

ADOLESCENT; ADULT; AGED; ANTIBODIES, VIRAL; BLOTTING, WESTERN; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RECOMBINANT PROTEINS; ROSEOLOVIRUS INFECTIONS; VIRAL NONSTRUCTURAL PROTEINS;

ANIMALIA; DNA VIRUSES; HERPESVIRIDAE; HUMAN HERPESVIRUS 6; ORYCTOLAGUS CUNICULUS;

EID: 0036841708     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.40.11.4131-4137.2002     Document Type: Article

References (56)

1. Ablashi, D. V., N. Balachandran, S. F. Josephs, C. L. Hung, G. R. F. Krueger, B. Kramarsky, S. Z. Salahuddin, and R. C. Gallo. 1991. Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184:545-552.
2. Ablashi, D. V., W. Lapps, M. Kaplan, J. E. Whitman, J. R. Richert, and G. R. Pearson. 1998. Human herpesvirus-6 (HHV-6) infection in multiple sclerosis: A preliminary report. Mult. Scler 4:490-496.
3. Ablashi, D. V., H. B. Eastman, C. B. Owen, M. M. Roman, J. Friedman, J. B. Zabriskie, D. L. Peterson, G. R. Pearson, and J. E. Whitman. 2000. Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients. J. Clin. Virol. 16:179-191.
4. Araujo, J. C., J. Doniger, F. Kashanchi, P. L. Hermonat, J. Thompson, and L. J. Rosenthal. 1995. Human herpesvirus 6A suppresses both transformation by H-ras and transcription by the H-ras and human immunodeficiency virus type 1 promoters. J. Virol. 69:4933-4940.
5. Asano, Y., T. Yoshikawa, S. Suga, T. Yazaki, K. Kondo, and K. Yamanishi. 1990. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet i:862-863.
6. Bertram, G., N. Dreiner, G. R. Krueger, A. Ramon, D. V. Ablashi, S. Z. Salahuddin, and N. Balachandram. 1991. Frequent double infection with Epstein-Barr virus and human herpesvirus-6 in patients with acute infectious mononucleosis. In Vivo 5:271-279.
7. Buchwald, D., P. R. Cheney, D. L. Peterson, B. Henry, S. B. Wormsley, A. Geiger, D. V. Ablashi, S. Z. Salahuddin, C. Saxinger, R. Biddle, B. Kikinis, F. A. Jolesz, T. Folks, N. Balachandran, J. B. Peter, R. C. Gallo, and A. L. Komaroff. 1992. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann. Intern. Med. 116:103-113.
8. Cao, Y., L. Qin, L. Zhang, J. Safrit, and D. D. Ho. 1995. Virologic and immunologic characterization of long term survivors of human immunodeficiency virus type 1 infection. N. Engl. J. Med. 332:201-208.
9. Carrigan, D., W. R. Drobyski, S. K. Russler, M. A. Tapper, K. K. Knox, and R. C. Ash. 1991. Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation. Lancet i:147-149.
10. Carrigan, D. R., and K. K. Knox. 1994. Human herpesvirus 6 (HHV-6) isolation from bone marrow: HHV-6 associated bone marrow suppression in bone marrow transplant patients. Blood 84:3307-3310.
11. Caselli, E., M. Betti, M. P. Grossi, P. G. Balboni, C. Rossi, C. Boarini, A. Cafaro, G. Barbanti-Brodano, B. Ensoli, and A. Caputo. 1999. DNA immunization with HIV-1 tat mutated in the trans activation domain induces humoral and cellular immune response against wild-type Tat. J. Immunol. 162:5631-5638.
12. Caselli, E., P. G. Balboni, C. Incorvaia, R. Argnani, F. Parmeggiani, E. Cassai, and R. Manservigi. 2000. Local and systemic inoculation of DNA or protein gB1s-based vaccines induce a protective immunity against rabbit ocular HSV-1 infection. Vaccine 19:1225-1231
13. Caserta, M. T., D. J. Mock, and S. Dewhurst. 2001. Human herpesvirus 6. Clin. Infect. Dis. 33:829-833.
14. Challoner, P. B., K. T. Smith, J. D. Parker, D. L. MacLeod, S. N. Coulter, T. M. Rose, E. R. Schultz, J. L. Bennett, R. L. Garber, M. Chang, P. A. Schad, P. M. Stewart, R. C. Novinski, J. P. Brown, and G. C. Burmer. 1995. Plaque associated expression of human herpesvirus-6 in multiple sclerosis. Proc. Natl. Acad. Sci. USA 92:7440-7444.
15. Chan, P. K., H. K. Ng, M. Hui, and A. F. Cheng. 2001. Prevalence and distribution of human herpesvirus 6 variants A and B in adult human brain. J. Med. Virol 64:42-46.
16. Chiorini, J. A., S. M. Wiener, L. Yang, R. H. Smith, B. Safer, N. P. Kilcoin, Y. Liu, E. Urcelay, and R. M. Kotin. 1996. The roles of AAV Rep proteins in gene expression and targeted integration. Curr. Top. Microbiol. Immunol. 218:25-33.
17. Cuomo, L., P. Trivedi, M. R. Cardillo, F. M. Gagliardi, A. Vecchione, R. Caruso, A. Calogero, L. Frati, A. Faggioni, and G. Ragona. 2001. Human herpesvirus 6 infection in neoplastic and normal brain tissue. J. Med. Virol. 63:45-51.
18. Drobyski, W. R., W. M. Dunne, E. M. Burd, K. K. Knox, R. C. Ash, M. M. Horowitz, N. Flomenberg, and D. R. Carrigan. 1993. Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: Evidence of a marrow-suppressive role for HHV-6 in vivo. J. Infect. Dis. 167:735-739.
19. Enbom, M., F.-Z. Wang, S. Fredrikson, C. Martin, E. Dahl, and A. Linde. 1999. Similar humoral and cellular immunological reactivities to human herpesvirus 6 in patients with multiple sclerosis and controls. Clin. Diagn. Lab. Immunol. 6:545-549.
20. Gompels, U. A., J. Nicholas, G. Lawrence, M. Jones, B. J. Thomson, M. Martin, S. Efstathiou, M. Craxton, and H. A. Macaulay. 1995. The DNA sequence of human herpesvirus-6: Structure, coding content, and genome evolution. Virology 209:29-51.
21. Hall, C. B., C. E. Long, K. C. Schnabel, M. T. Caserta, K. M. McIntyre, M. A. Costanzo, A. Knott, S. Dewhurst, R. A. Insel, and L. G. Epstein. 1994. Human herpesvirus-6 infection in children: A prospective study of complications and reactivations. N. Engl. J. Med. 331:432-438.
22. Hoffman, A., E. Kirn, A. Kuerten, C. Sander, G. R. Krueger, and D. V. Ablashi. 1991. Active human herpesvirus-6 (HHV-6) infection associated with Kikuchi-Fujimoto disease and systemic lupus erythematosus (SLE). In Vivo 5:265-269.
23. Im, D. S., and N. Muzyczka. 1990. The AAV origin binding protein rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell 61:447-457.
24. Im, D. S., and N. Muzyczka. 1992. Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization. J. Virol. 66:1119-1128.
25. Ishiguro, N., S. Yamada, T. Takahashi, Y. Takahashi, T. Togashi, T. Okuno, and K. Yamanishi. 1990. Meningo-encephalitis associated with HHV-6 related exanthem subitum. Acta Paediatr. Scand, 79:987-989.
26. Kamei, A., S. Ichinohe, R. Onuma, S. Hiraga, and T. Fujiwara. 1997. Acute disseminated demyelination due to primary human herpesvirus-6 infection. Eur J. Pediatr. 156:709-712.
27. Knox, K. K., D. P. Harrington, and D. R. Carrigan. 1995. Fulminant human herpesvirus six (HHV-6) encephalitis in an HIV infected infant. J. Med. Virol. 45:288-292.
28. Knox, K. K., and D. R. Carrigan. 1995. Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 9:69-73.
29. Krueger, G. R., D. V. Ablashi, S. F. Josephs, S. Z. Salahuddin, U. Lembke, A. Ramon, and G. Bertram. 1991. Clinical and diagnostic techniques of human herpesvirus-6 (HHV-6) infection. In Vivo 5:287-295.
30. Levine, P. H., N. Jahan, P. Murari, M. Manak, and E. S. Jaffe. 1992. Detection of human herpesvirus 6 in tissue involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). J. Infect. Dis. 166:291-295.
31. Linden, R. M., P. Ward, C. Giraud, E. Winocour, and K. I. Berns. 1996. Site-specific integration by adeno-associated virus. Proc. Natl. Acad. Sci. USA 93:11288-11294.
32. Linden, R. M., E. Winocour, and K. I. Berns. 1996. The recombination signals for adeno-associated virus site-specific integration. Proc. Natl. Acad. Sci. USA 93:7966-7972.
33. Luppi, M., P. Barozzi, R. Marasca, and G. Torelli. 1994. Integration of human herpesvirus-6 (HHV-6) gerome in chromosome 17 in two lymphoma patients. Leukemia 8(Suppl. 1):S41-S45.
34. Luppi, M., P. Barozzi, C. M. Morris, E. Merelli, and G. Torelli. 1998. Integration of human herpesvirus 6 genome in human chromosomes. Lancet 352:1707-1708.
35. Lusso, P., and R. C. Gallo. 1995. Human herpesvirus 6 in AIDS. Immunol. Today 16:67-71.
36. Matsuda, Y., J. Hara, H. Miyoshi, Y. Osugi, H. Fujisaki, K. Takai, H. Ohta, K. Tanaka-Taya, K. Yamanishi, and S. Okada. 1999. Thrombotic microangiopathy associated with reactivation of human herpesvirus-6 following highdose chemotherapy with autologous bone marrow transplantation in young children. Bone Marrow Transplant 24:919-923.
37. Mori, Y., P. Dhepakson, T. Shimamoto, K. Ueda, Y. Gomi, H. Tani, Y. Matsuura, and K. Yamanishi. 2000. Expression of human herpesvirus 6B rep within infected cells and binding of its gene product to the TATA-binding protein in vitro and in vivo. J. Virol. 74:6096-6104.
38. Niederman, J. C., C. R. Liu, M. H. Kaplan, and N. A. Brown. 1988. Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet ii:817-819.
39. Nielsen, L., A. M. Larsen, M. Munk, and B. F. Vestergaard. 1997. Human herpesvirus-6 immunoglobulin G antibodies in patients with multiple sclerosis. Acta Neurol. Scand. Suppl. 169:76-78.
40. Rapp, J. C., L. T. Krug, N. Inoue, T. R. Dambaugh, and P. E. Pellett. 2000. U94, the human herpesvirus 6 homolog of the parvovirus nonstructural gene, is highly conserved among isolates and is expressed at low mRNA levels as a spliced transcript. Virology 268:504-516.
41. Rodman, T. C., H. Pruslin, S. E. To, and R. Winston. 1992. HIV-Tat reactive antibodies present in normal HIV-negative sera and depleted in HIV-positive sera: Identification of the epitope. J. Exp. Med. 175:1247-1253.
42. Rotola, A., T. Ravaioli, A. Gonelli, S. Dewhurst, E. Cassai, and D. Di Luca. 1998. U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture. Proc. Natl. Acad. Sci. USA 95:13911-13916.
43. Rotola, A., E. Cassai, M. R. Tola, E. Granieri, and D. Di Luca. 1999. Human herpesvirus 6 is latent in peripheral blood of patients with relapsing remitting multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 67:529-531.
44. Rotola, A., E. Caselli, E. Cassai, M. R. Tola, E. Granieri, and D. Di Luca. 2000. Novel human herpesviruses and multiple sclerosis. J. Neurovirol. 6(Suppl. 2):S88-S91.
45. Santoro, E., P. E. Kennedy, G. Locatelli, M. S. Malnati, E. A. Berger, and P. Lusso. 1999. CD46 is a cellular receptor for human herpesvirus 6. Cell 99:817-827.
46. Sola, P., E. Merelli, R. Marasea, M. Poggi, M. Luppi, M. Montorsi, and G. Torelli. 1993. Human herpesvirus-6 and multiple sclerosis: Survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction. J. Neurol. Neurosurg. Psychiatry 5:917-919.
47. Soldan, S. S., R. Berti, N. Salem, P. Seechiero, L. Flamand, P. A. Calabresi, M. B. Brennan, H. W. Maloni, H. F. McFarland, H. C. Lin, M. Patnaik, and S. Jacobson. 1997. Association of human herpesvirus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat. Med. 3:1394-1397.
48. Steeper, T. A., C. A. Horwitz, D. V. Ablashi, S. Z. Salahuddin, C. Saxinger, R. Saltzman, and B. Schwartz. 1990. The spectrum of clinical and laboratory findings resulting from human herpesvirus-6 (HHV-6) in patients with mononucleosis-like illness not resulting from Epstein-Barr virus or cytomegalovirus. Am. J. Clin. Pathol. 93:776-783.
49. Surosky, R. T., M. Urabe, S. G. Godwin, S. A. McQuiston, G. J. Kurtzman, K. Ozawa, and G. Natsoulis. 1997. Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome. J. Virol. 71:7951-7959.
50. Thomson, B. J., S. Efstathiou, and R. W. Honess. 1991. Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus 6. Nature 351:78-80.
51. Thomson, B. J., F. W. Weindler, D. Gray, V. Schwaab, and R. Heilbronn. 1994. Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression. Virology 204:304-311.
52. Torelli, G. P., P. Barozzi, P. Marasca, P. Cocconcelli, E. Merelli, L. Ceccherini-Nelli, S. Ferrari, and M. Luppi. 1995. Targeted integration of human herpesvirus 6 in the p arm of chromosome 17 of human peripheral blood mononuclear cells in vivo. J. Med. Virol. 46:178-188.
53. Webb, D. W., B. H. Bjornson, M. A. Sargent, J. Hukin, and E. E. Thomas. 1997. Basal ganglia infarction associated with HHV-6 infection. Arch. Dis. Child. 76:362-364.
54. Wilborn, F., C. A. Schmidt, V. Brinkmann K. Jendroska, H. Oettle, and W. Siegert. 1994. A potential role for human herpesvirus 6 in nervous system disease. J. Neuroimmunol. 49:213-214.
55. Yamanishi, K., T. Okuno, K. Shiraki, M. Takahashi, T. Kondo, Y. Asano, and T. Kurata. 1988. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet i:1065-1067.
56. Yoshikawa, T., and Y. Asano. 2000. Central nervous system complications in human herpesvirus-6 infection. Brain Dev. 22:307-314.