Intrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating diseases presenting as oligoclonal bands in cerebrospinal fluid

Journal of Neuroimmunology

Volumn 237, Issue 1-2, 2011, Pages 93-97

  Virtanen, Jussi O ^a,b   Pietiläinen Nicklén, Jenna ^a,b   Uotila, Lasse ^b   Färkkilä, Markus ^b   Vaheri, Antti ^a,b   Koskiniemi, Marjaleena ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Cerebrospinal fluid; Demyelination; Human herpesvirus 6; Intrathecal antibody; Multiple sclerosis; Oligoclonal igg bands

Indexed keywords

OLIGOCLONAL BAND; VIRUS ANTIBODY; VIRUS ANTIGEN;

ADOLESCENT; ADULT; AGED; ANTIBODY PRODUCTION; ARTICLE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DEMYELINATING DISEASE; FEMALE; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOBLOTTING; IMMUNOREACTIVITY; ISOELECTRIC FOCUSING; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; DEMYELINATING AUTOIMMUNE DISEASES, CNS; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELIN PROTEINS; NERVE FIBERS, MYELINATED; OLIGOCLONAL BANDS; ROSEOLOVIRUS INFECTIONS; YOUNG ADULT;

EID: 80051470033     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.06.012     Document Type: Article

References (25)

1. Alvarez-Lafuente R., Garcia-Montojo M., De las Heras V., et al. Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients. J. Clin. Virol. 2006, 37(Suppl 1):S24-S26.
2. Andersson M., Alvarez-Cermeno J., Bernardi G., et al. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J. Neurol. Neurosurg. Psychiatr. 1994, 57:897-902.
3. Arbuckle J.H., Medveczky M.M., Luka J., et al. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:5563-5568.
4. Burgoon M.P., Hammack B.N., Owens G.P., et al. Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV. Ann. Neurol. 2003, 54:459-463.
5. Challoner P.B., Smith K.T., Parker J.D., et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:7440-7444.
6. Derfuss T., Gurkov R., Then Bergh F., et al. Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain 2001, 124:1325-1335.
7. Derfuss T., Hohlfeld R., Meinl E. Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B-cell response. J. Neurol. 2005, 252:968-971.
8. Freedman M.S., Thompson E.J., Deisenhammer F., et al. Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement. Arch. Neurol. 2005, 62:865-870.
9. Friedman J.E., Lyons M.J., Cu G., et al. The association of the human herpesvirus-6 and MS. Mult. Scler. 1999, 5:355-362.
10. Gilden D.H. Viruses and multiple sclerosis. JAMA 2001, 286:3127-3129.
11. Goodman A.D., Mock D.J., Powers J.M., et al. Human herpesvirus 6 genome and antigen in acute multiple sclerosis lesions. J. Infect. Dis. 2003, 187:1365-1376.
12. Holmoy T. The discovery of oligoclonal bands: a 50-year anniversary. Eur. Neurol. 2009, 62:311-315.
13. McDonald W.I., Compston A., Edan G., et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001, 50:121-127.
14. Owens G.P., Bennett J.L., Lassmann H., et al. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann. Neurol. 2009, 65:639-649.
15. Pietiläinen J., Virtanen J.O., Uotila L., et al. HHV-6 infection in multiple sclerosis. A clinical and laboratory analysis. Eur. J. Neurol. 2010, 17:506-509.
16. Polman C.H., Reingold S.C., Edan G., et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann. Neurol. 2005, 58:840-846.
17. Reiber H., Ungefehr S., Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult. Scler. 1998, 4:111-117.
18. Rotola A., Merlotti I., Caniatti L., et al. Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease. Mult. Scler. 2004, 10:348-354.
19. Sindic C.J., Monteyne P., Laterre E.C. The intrathecal synthesis of virus-specific oligoclonal IgG in multiple sclerosis. J. Neuroimmunol. 1994, 54:75-80.
20. Skorstad G., Vandvik B., Vartdal F., et al. MS and clinically isolated syndromes: shared specificity but diverging clonal patterns of virus-specific IgG antibodies produced in vivo and by CSF B cells in vitro. Eur. J. Neurol. 2009, 16:1124-1129.
21. Vaheri A., Keski-Oja J., Salonen E.M., et al. Cerebrospinal fluid IgG bands and virus-specific IgG, IgM, and IgA antibodies in herpes simplex virus encephalitis. J. Neuroimmunol. 1982, 3:247-261.
22. Vandvik B., Norrby E., Nordal H.J., et al. Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. Scand. J. Immunol. 1976, 5:979-992.
23. Virtanen J.O., Zabriskie J.B., Siren V., et al. Co-localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue. Med. Sci. Monit. 2005, 11:BR84-BR87.
24. Virtanen J.O., Färkkilä M., Multanen J., et al. Evidence for human herpesvirus 6 variant A antibodies in multiple sclerosis: diagnostic and therapeutic implications. J. Neurovirol. 2007, 13:347-352.
25. Voumvourakis K.I., Kitsos D.K., Tsiodras S., et al. Human herpesvirus 6 infection as a trigger of multiple sclerosis. Mayo Clin. Proc. 2010, 85:1023-1030.