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Volumn 13, Issue 3, 2013, Pages 287-297

Epstein-Barr virus and multiple sclerosis: Association or causation?

Author keywords

Epstein Barr nuclear antigen; Epstein Barr virus; infectious mononucleosis; latitude; multiple sclerosis; seroprevalence; temporality

Indexed keywords

ACICLOVIR; PLACEBO; RITUXIMAB; VALACICLOVIR; VITAMIN D;

EID: 84874631683     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.13.6     Document Type: Review
Times cited : (46)

References (80)
  • 2
    • 34247590137 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis. Part I: The role of infection
    • Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann. Neurol. 61(4), 288-299 (2007).
    • (2007) Ann. Neurol , vol.61 , Issue.4 , pp. 288-299
    • Ascherio, A.1    Munger, K.L.2
  • 3
    • 11244266124 scopus 로고    scopus 로고
    • Latent and lytic Epstein-Barr virus replication strategies
    • Tsurumi T, Fujita M, Kudoh A. Latent and lytic Epstein-Barr virus replication strategies. Rev. Med. Virol. 15(1), 3-15 (2005).
    • (2005) Rev. Med. Virol , vol.15 , Issue.1 , pp. 3-15
    • Tsurumi, T.1    Fujita, M.2    Kudoh, A.3
  • 4
    • 0020639761 scopus 로고
    • Epstein-Barr virus infection and antibody synthesis in patients with multiple sclerosis
    • Bray PF, Bloomer LC, Salmon VC, Bagley MH, Larsen PD. Epstein-Barr virus infection and antibody synthesis in patients with multiple sclerosis. Arch. Neurol. 40(7), 406-408 (1983).
    • (1983) Arch. Neurol , vol.40 , Issue.7 , pp. 406-408
    • Bray, P.F.1    Bloomer, L.C.2    Salmon, V.C.3    Bagley, M.H.4    Larsen, P.D.5
  • 5
    • 79952553854 scopus 로고    scopus 로고
    • Evaluation of four commercial systems for the diagnosis of Epstein-Barr virus primary infections
    • de Ory F, Guisasola ME, Sanz JC, García-Bermejo I. Evaluation of four commercial systems for the diagnosis of Epstein-Barr virus primary infections. Clin. Vaccine Immunol. 18(3), 444-448 (2011).
    • (2011) Clin. Vaccine Immunol , vol.18 , Issue.3 , pp. 444-448
    • De Ory, F.1    Guisasola, M.E.2    Sanz, J.C.3    García-Bermejo, I.4
  • 6
    • 84873663540 scopus 로고    scopus 로고
    • The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: A meta-analysis
    • doi:10.1177/1352458512449682 Epub ahead of print
    • Pakpoor J, Disanto G, Gerber JE et al. The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: a meta-analysis. Mult. Scler. doi:10.1177/1352458512449682 (2012) (Epub ahead of print).
    • (2012) Mult. Scler
    • Pakpoor, J.1    Disanto, G.2    Gerber, J.E.3
  • 7
    • 0034001316 scopus 로고    scopus 로고
    • Epstein-Barr virus and multiple sclerosis
    • Ascherio A, Munch M. Epstein-Barr virus and multiple sclerosis. Epidemiology 11(2), 220-224 (2000).
    • (2000) Epidemiology , vol.11 , Issue.2 , pp. 220-224
    • Ascherio, A.1    Munch, M.2
  • 8
    • 33845706602 scopus 로고    scopus 로고
    • High seroprevalence of Epstein-Barr virus in children with multiple sclerosis
    • Pohl D, Krone B, Rostasy K et al. High seroprevalence of Epstein-Barr virus in children with multiple sclerosis. Neurology 67(11), 2063-2065 (2006).
    • (2006) Neurology , vol.67 , Issue.11 , pp. 2063-2065
    • Pohl, D.1    Krone, B.2    Rostasy, K.3
  • 9
    • 77952921203 scopus 로고    scopus 로고
    • Primary infection with the Epstein-Barr virus and risk of multiple sclerosis
    • Levin LI, Munger KL, O'Reilly EJ, Falk KI, Ascherio A. Primary infection with the Epstein-Barr virus and risk of multiple sclerosis. Ann. Neurol. 67(6), 824-830 (2010).
    • (2010) Ann. Neurol , vol.67 , Issue.6 , pp. 824-830
    • Levin, L.I.1    Munger, K.L.2    O'Reilly, E.J.3    Falk, K.I.4    Ascherio, A.5
  • 10
    • 0031779318 scopus 로고    scopus 로고
    • The significance of Epstein-Barr virus seropositivity in multiple sclerosis patients?
    • Munch M, Riisom K, Christensen T, Møller-Larsen A, Haahr S. The significance of Epstein-Barr virus seropositivity in multiple sclerosis patients? Acta Neurol. Scand. 97(3), 171-174 (1998).
    • (1998) Acta Neurol. Scand , vol.97 , Issue.3 , pp. 171-174
    • Munch, M.1    Riisom, K.2    Christensen, T.3    Møller-Larsen, A.4    Haahr, S.5
  • 11
    • 18944373385 scopus 로고    scopus 로고
    • Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis
    • Levin LI, Munger KL, Rubertone MV et al. Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA 293(20), 2496-2500 (2005).
    • (2005) JAMA , vol.293 , Issue.20 , pp. 2496-2500
    • Levin, L.I.1    Munger, K.L.2    Rubertone, M.V.3
  • 12
    • 0035956494 scopus 로고    scopus 로고
    • Epstein-Barr virus antibodies and risk of multiple sclerosis: A prospective study
    • Ascherio A, Munger KL, Lennette ET et al. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA 286(24), 3083-3088 (2001).
    • (2001) JAMA , vol.286 , Issue.24 , pp. 3083-3088
    • Ascherio, A.1    Munger, K.L.2    Lennette, E.T.3
  • 13
    • 33745107637 scopus 로고    scopus 로고
    • Epstein-Barr virus and multiple sclerosis: Evidence of association from a prospective study with long-term follow-up
    • DeLorenze GN, Munger KL, Lennette ET, Orentreich N, Vogelman JH, Ascherio A. Epstein-Barr virus and multiple sclerosis: evidence of association from a prospective study with long-term follow-up. Arch. Neurol. 63(6), 839-844 (2006).
    • (2006) Arch. Neurol , vol.63 , Issue.6 , pp. 839-844
    • Delorenze, G.N.1    Munger, K.L.2    Lennette, E.T.3    Orentreich, N.4    Vogelman, J.H.5    Ascherio, A.6
  • 14
    • 2942752168 scopus 로고    scopus 로고
    • An altered immune response to Epstein-Barr virus in multiple sclerosis: A prospective study
    • Sundström P, Juto P, Wadell G et al. An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study. Neurology 62(12), 2277-2282 (2004).
    • (2004) Neurology , vol.62 , Issue.12 , pp. 2277-2282
    • Sundström, P.1    Juto, P.2    Wadell, G.3
  • 15
    • 84869239818 scopus 로고    scopus 로고
    • Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis
    • Décard BF, von Ahsen N, Grunwald T et al. Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis. J. Neurol. Neurosurg. Psychiatr. 83(12), 1170-1173 (2012).
    • (2012) J. Neurol. Neurosurg. Psychiatr , vol.83 , Issue.12 , pp. 1170-1173
    • Décard, B.F.1    Von Ahsen, N.2    Grunwald, T.3
  • 16
    • 18944396623 scopus 로고    scopus 로고
    • EBV and systemic lupus erythematosus: A new perspective
    • Gross AJ, Hochberg D, Rand WM, Thorley-Lawson DA. EBV and systemic lupus erythematosus: a new perspective. J. Immunol. 174(11), 6599-6607 (2005).
    • (2005) J. Immunol , vol.174 , Issue.11 , pp. 6599-6607
    • Gross, A.J.1    Hochberg, D.2    Rand, W.M.3    Thorley-Lawson, D.A.4
  • 17
    • 1642334164 scopus 로고    scopus 로고
    • Persistence of the Epstein-Barr virus and the origins of associated lymphomas
    • Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N. Engl. J. Med. 350(13), 1328-1337 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.13 , pp. 1328-1337
    • Thorley-Lawson, D.A.1    Gross, A.2
  • 19
    • 0016304894 scopus 로고
    • Infectious mononucleosis at the United States Military Academy. A prospective study of a single class over four years
    • Hallee TJ, Evans AS, Niederman JC, Brooks CM, Voegtly JH. Infectious mononucleosis at the United States Military Academy. A prospective study of a single class over four years. Yale J. Biol. Med. 47(3), 182-195 (1974).
    • (1974) Yale J. Biol. Med , vol.47 , Issue.3 , pp. 182-195
    • Hallee, T.J.1    Evans, A.S.2    Niederman, J.C.3    Brooks, C.M.4    Voegtly, J.H.5
  • 20
    • 33846091559 scopus 로고    scopus 로고
    • Multiple sclerosis after infectious mononucleosis
    • Nielsen TR, Rostgaard K, Nielsen NM et al. Multiple sclerosis after infectious mononucleosis. Arch. Neurol. 64(1), 72-75 (2007).
    • (2007) Arch. Neurol , vol.64 , Issue.1 , pp. 72-75
    • Nielsen, T.R.1    Rostgaard, K.2    Nielsen, N.M.3
  • 21
  • 22
    • 77949424680 scopus 로고    scopus 로고
    • Environmental factors and their timing in adult-onset multiple sclerosis
    • Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV. Environmental factors and their timing in adult-onset multiple sclerosis. Nat. Rev. Neurol. 6(3), 156-166 (2010).
    • (2010) Nat. Rev. Neurol , vol.6 , Issue.3 , pp. 156-166
    • Handel, A.E.1    Giovannoni, G.2    Ebers, G.C.3    Ramagopalan, S.V.4
  • 23
    • 38949107656 scopus 로고    scopus 로고
    • Environmental factors and multiple sclerosis
    • Ebers GC Environmental factors and multiple sclerosis. Lancet Neurol. 7, 268-277 (2008).
    • (2008) Lancet Neurol , vol.7 , pp. 268-277
    • Ebers, G.C.1
  • 24
    • 79955756301 scopus 로고    scopus 로고
    • Geography of hospital admissions for multiple sclerosis in England and comparison with the geography of hospital admissions for infectious mononucleosis: A descriptive study
    • Ramagopalan SV, Hoang U, Seagroatt V et al. Geography of hospital admissions for multiple sclerosis in England and comparison with the geography of hospital admissions for infectious mononucleosis: a descriptive study. J. Neurol. Neurosurg. Psychiatr. 82(6), 682-687 (2011).
    • (2011) J. Neurol. Neurosurg. Psychiatr , vol.82 , Issue.6 , pp. 682-687
    • Ramagopalan, S.V.1    Hoang, U.2    Seagroatt, V.3
  • 25
    • 41149158618 scopus 로고    scopus 로고
    • A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia
    • Pordeus V, Barzilai O, Sherer Y et al. A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. Isr. Med. Assoc. J. 10(1), 65-68 (2008).
    • (2008) Isr. Med. Assoc. J , vol.10 , Issue.1 , pp. 65-68
    • Pordeus, V.1    Barzilai, O.2    Sherer, Y.3
  • 26
    • 84874346355 scopus 로고    scopus 로고
    • Epstein-Barr virus, latitude and multiple sclerosis
    • doi:10.1177/1352458512451942 Epub ahead of print
    • Disanto G, Pakpoor J, Morahan JM et al. Epstein-Barr virus, latitude and multiple sclerosis. Mult. Scler. doi:10.1177/1352458512451942 (2012) (Epub ahead of print).
    • (2012) Mult. Scler
    • Disanto, G.1    Pakpoor, J.2    Morahan, J.M.3
  • 27
    • 77953394241 scopus 로고    scopus 로고
    • Multiple sclerosis: Risk factors, prodromes, and potential causal pathways
    • Ramagopalan SV, Dobson R, Meier UC, Giovannoni G. Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol. 9(7), 727-739 (2010).
    • (2010) Lancet Neurol , vol.9 , Issue.7 , pp. 727-739
    • Ramagopalan, S.V.1    Dobson, R.2    Meier, U.C.3    Giovannoni, G.4
  • 28
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296(23), 2832-2838 (2006).
    • (2006) JAMA , vol.296 , Issue.23 , pp. 2832-2838
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3    Howard, N.S.4    Ascherio, A.5
  • 29
    • 36448929119 scopus 로고    scopus 로고
    • Vitamin D status modulates the immune response to Epstein-Barr virus: Synergistic effect of risk factors in multiple sclerosis
    • Holmøy T. Vitamin D status modulates the immune response to Epstein-Barr virus: synergistic effect of risk factors in multiple sclerosis. Med. Hypotheses 70(1), 66-69 (2008).
    • (2008) Med. Hypotheses , vol.70 , Issue.1 , pp. 66-69
    • Holmøy, T.1
  • 30
    • 79955512594 scopus 로고    scopus 로고
    • Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus Reactivation
    • Zwart SR, Mehta SK, Ploutz-Snyder R et al. Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus Reactivation. J. Nutr. 141(4), 692-697 (2011).
    • (2011) J. Nutr , vol.141 , Issue.4 , pp. 692-697
    • Zwart, S.R.1    Mehta, S.K.2    Ploutz-Snyder, R.3
  • 31
    • 80053608697 scopus 로고    scopus 로고
    • Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: A prospective study among United States military personnel
    • Munger KL, Levin LI, O'Reilly EJ, Falk KI, Ascherio A. Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel. Mult. Scler. 17(10), 1185-1193 (2011).
    • (2011) Mult. Scler , vol.17 , Issue.10 , pp. 1185-1193
    • Munger, K.L.1    Levin, L.I.2    O'Reilly, E.J.3    Falk, K.I.4    Ascherio, A.5
  • 32
    • 84867779322 scopus 로고    scopus 로고
    • CD8+ T-cell deficiency, Epstein-Barr virus infection, vitamin D deficiency, and steps to autoimmunity: A unifying hypothesis
    • Pender MP. CD8+ T-cell deficiency, Epstein-Barr virus infection, vitamin D deficiency, and steps to autoimmunity: a unifying hypothesis. Autoimmune Dis. 2012, 189096 (2012).
    • (2012) Autoimmune Dis. 2012 , pp. 189096
    • Pender, M.P.1
  • 33
    • 46849084346 scopus 로고    scopus 로고
    • Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis
    • Jilek S, Schluep M, Meylan P et al. Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis. Brain 131(Pt 7), 1712-1721 (2008).
    • (2008) Brain , vol.131 , Issue.PART 7 , pp. 1712-1721
    • Jilek, S.1    Schluep, M.2    Meylan, P.3
  • 34
    • 1542285269 scopus 로고    scopus 로고
    • Cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transformed B cells
    • Holmøy T, Vartdal F. Cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transformed B cells. J. Neurovirol. 10(1), 52-56 (2004).
    • (2004) J. Neurovirol , vol.10 , Issue.1 , pp. 52-56
    • Holmøy, T.1    Vartdal, F.2
  • 35
    • 0032985551 scopus 로고    scopus 로고
    • Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: Towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes
    • Scotet E, Peyrat MA, Saulquin X et al. Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes. Eur. J. Immunol. 29(3), 973-985 (1999).
    • (1999) Eur. J. Immunol , vol.29 , Issue.3 , pp. 973-985
    • Scotet, E.1    Peyrat, M.A.2    Saulquin, X.3
  • 36
    • 0347997289 scopus 로고    scopus 로고
    • Altered CD8+ T cell responses to selected Epstein-Barr virus immunodominant epitopes in patients with multiple sclerosis
    • Höllsberg P, Hansen HJ, Haahr S. Altered CD8+ T cell responses to selected Epstein-Barr virus immunodominant epitopes in patients with multiple sclerosis. Clin. Exp. Immunol. 132(1), 137-143 (2003).
    • (2003) Clin. Exp. Immunol , vol.132 , Issue.1 , pp. 137-143
    • Höllsberg, P.1    Hansen, H.J.2    Haahr, S.3
  • 37
    • 33745104765 scopus 로고    scopus 로고
    • Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis
    • Lünemann JD, Edwards N, Muraro PA et al. Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis. Brain 129(Pt 6), 1493-1506 (2006).
    • (2006) Brain , vol.129 , Issue.PART 6 , pp. 1493-1506
    • Lünemann, J.D.1    Edwards, N.2    Muraro, P.A.3
  • 38
    • 36549034729 scopus 로고    scopus 로고
    • Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain
    • Serafini B, Rosicarelli B, Franciotta D et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J. Exp. Med. 204(12), 2899-2912 (2007).
    • (2007) J. Exp. Med , vol.204 , Issue.12 , pp. 2899-2912
    • Serafini, B.1    Rosicarelli, B.2    Franciotta, D.3
  • 39
    • 78651286611 scopus 로고    scopus 로고
    • Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes
    • Yenamandra SP, Hellman U, Kempkes B et al. Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes. Cell. Mol. Life Sci. 67(24), 4249-4256 (2010).
    • (2010) Cell. Mol. Life Sci , vol.67 , Issue.24 , pp. 4249-4256
    • Yenamandra, S.P.1    Hellman, U.2    Kempkes, B.3
  • 41
    • 34548058326 scopus 로고    scopus 로고
    • Cigarette smoking and risk of Hodgkin lymphoma: A populationbased case-control study
    • Hjalgrim H, Ekström-Smedby K, Rostgaard K et al. Cigarette smoking and risk of Hodgkin lymphoma: a populationbased case-control study. Cancer Epidemiol. Biomarkers Prev. 16(8), 1561-1566 (2007).
    • (2007) Cancer Epidemiol. Biomarkers Prev , vol.16 , Issue.8 , pp. 1561-1566
    • Hjalgrim, H.1    Ekström-Smedby, K.2    Rostgaard, K.3
  • 42
    • 2942564310 scopus 로고    scopus 로고
    • Heterogeneity of risk factors and antibody profiles in Epstein-Barr virus genomepositive and-negative hodgkin lymphoma
    • Chang ET, Zheng T, Lennette ET et al. Heterogeneity of risk factors and antibody profiles in Epstein-Barr virus genomepositive and-negative hodgkin lymphoma. J. Infect. Dis. 189(12), 2271-2281 (2004).
    • (2004) J. Infect. Dis , vol.189 , Issue.12 , pp. 2271-2281
    • Chang, E.T.1    Zheng, T.2    Lennette, E.T.3
  • 43
    • 77951728213 scopus 로고    scopus 로고
    • Combined effects of smoking, anti-EBNA antibodies, and HLADRB1* 1501 on multiple sclerosis risk
    • Simon KC, van der Mei IA, Munger KL et al. Combined effects of smoking, anti-EBNA antibodies, and HLADRB1* 1501 on multiple sclerosis risk. Neurology 74(17), 1365-1371 (2010).
    • (2010) Neurology , vol.74 , Issue.17 , pp. 1365-1371
    • Simon, K.C.1    Van Der Mei, I.A.2    Munger, K.L.3
  • 44
    • 84866887824 scopus 로고    scopus 로고
    • Lack of replication of interaction between EBNA1 IgG and smoking in risk for multiple sclerosis
    • Sundqvist E, Sundström P, Lindén M et al. Lack of replication of interaction between EBNA1 IgG and smoking in risk for multiple sclerosis. Neurology 79(13), 1363-1368 (2012).
    • (2012) Neurology , vol.79 , Issue.13 , pp. 1363-1368
    • Sundqvist, E.1    Sundström, P.2    Lindén, M.3
  • 45
    • 41549132135 scopus 로고    scopus 로고
    • Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis
    • De Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA, Ascherio A. Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. Neurology 70(13 Pt 2), 1113-1118 (2008).
    • (2008) Neurology , vol.70 , Issue.13 PART 2 , pp. 1113-1118
    • De Jager, P.L.1    Simon, K.C.2    Munger, K.L.3    Rioux, J.D.4    Hafler, D.A.5    Ascherio, A.6
  • 46
    • 58149348645 scopus 로고    scopus 로고
    • EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for multiple sclerosis: A case-control study
    • Sundström P, Nyström L, Jidell E, Hallmans G. EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for multiple sclerosis: a case-control study. Mult. Scler. 14(8), 1120-1122 (2008).
    • (2008) Mult. Scler , vol.14 , Issue.8 , pp. 1120-1122
    • Sundström, P.1    Nyström, L.2    Jidell, E.3    Hallmans, G.4
  • 47
    • 38549083107 scopus 로고    scopus 로고
    • HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis
    • Brynedal B, Duvefelt K, Jonasdottir G et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS ONE 2(7), e664 (2007).
    • (2007) PLoS ONE , vol.2 , Issue.7
    • Brynedal, B.1    Duvefelt, K.2    Jonasdottir, G.3
  • 48
    • 84855915565 scopus 로고    scopus 로고
    • Epstein-Barr virus and multiple sclerosis: Interaction with HLA
    • Sundqvist E, Sundström P, Lindén M et al. Epstein-Barr virus and multiple sclerosis: interaction with HLA. Genes Immun. 13(1), 14-20 (2012).
    • (2012) Genes Immun , vol.13 , Issue.1 , pp. 14-20
    • Sundqvist, E.1    Sundström, P.2    Lindén, M.3
  • 49
    • 79952138032 scopus 로고    scopus 로고
    • Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis
    • Hedström AK, Sundqvist E, Bäärnhielm M et al. Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis. Brain 134(Pt 3), 653-664 (2011).
    • (2011) Brain , vol.134 , Issue.PART 3 , pp. 653-664
    • Hedström, A.K.1    Sundqvist, E.2    Bäärnhielm, M.3
  • 50
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80(5), 695-705 (1995).
    • (1995) Cell , vol.80 , Issue.5 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 51
    • 0032476612 scopus 로고    scopus 로고
    • In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis
    • Ufret-Vincenty RL, Quigley L, Tresser N et al. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. J. Exp. Med. 188(9), 1725-1738 (1998).
    • (1998) J. Exp. Med , vol.188 , Issue.9 , pp. 1725-1738
    • Ufret-Vincenty, R.L.1    Quigley, L.2    Tresser, N.3
  • 52
    • 0036793245 scopus 로고    scopus 로고
    • A functional and structural basis for TCR cross-reactivity in multiple sclerosis
    • Lang HL, Jacobsen H, Ikemizu S et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat. Immunol. 3(10), 940-943 (2002).
    • (2002) Nat. Immunol , vol.3 , Issue.10 , pp. 940-943
    • Lang, H.L.1    Jacobsen, H.2    Ikemizu, S.3
  • 53
    • 7244254454 scopus 로고    scopus 로고
    • Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein
    • Holmøy T, Kvale EØ, Vartdal F. Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein. J. Neurovirol. 10(5), 278-283 (2004).
    • (2004) J. Neurovirol , vol.10 , Issue.5 , pp. 278-283
    • Holmøy, T.1    Kvale, EØ.2    Vartdal, F.3
  • 54
    • 0242270822 scopus 로고    scopus 로고
    • Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases
    • Pender MP. Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases. Trends Immunol. 24(11), 584-588 (2003).
    • (2003) Trends Immunol , vol.24 , Issue.11 , pp. 584-588
    • Pender, M.P.1
  • 55
    • 0034212893 scopus 로고    scopus 로고
    • Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis
    • van Noort JM, Bajramovic JJ, Plomp AC, van Stipdonk MJ. Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis. J. Neuroimmunol. 105(1), 46-57 (2000).
    • (2000) J. Neuroimmunol , vol.105 , Issue.1 , pp. 46-57
    • Van Noort, J.M.1    Bajramovic, J.J.2    Plomp, A.C.3    Van Stipdonk, M.J.4
  • 56
    • 79958728110 scopus 로고    scopus 로고
    • The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
    • Pender MP. The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis. Neuroscientist 17(4), 351-367 (2011).
    • (2011) Neuroscientist , vol.17 , Issue.4 , pp. 351-367
    • Pender, M.P.1
  • 58
    • 0025870054 scopus 로고
    • Just another dubious virus in cells from a patient with multiple sclerosis?
    • Haahr S, Sommerlund M, Møller-Larsen A, Nielsen R, Hansen HJ. Just another dubious virus in cells from a patient with multiple sclerosis? Lancet 337(8745), 863-864 (1991).
    • (1991) Lancet , vol.337 , Issue.8745 , pp. 863-864
    • Haahr, S.1    Sommerlund, M.2    Møller-Larsen, A.3    Nielsen, R.4    Hansen, H.J.5
  • 59
    • 0025760695 scopus 로고
    • Isolation of retrovirus from patients with multiple sclerosis
    • Perron H, Lalande B, Gratacap B et al. Isolation of retrovirus from patients with multiple sclerosis. Lancet 337(8745), 862-863 (1991).
    • (1991) Lancet , vol.337 , Issue.8745 , pp. 862-863
    • Perron, H.1    Lalande, B.2    Gratacap, B.3
  • 60
    • 56749093793 scopus 로고    scopus 로고
    • Multiple sclerosis and HERV-W/MSRV: A multicentric study
    • Arru G, Mameli G, Asone V et al. Multiple sclerosis and HERV-W/MSRV: a multicentric study. Int. J. Biomed. Sci. 3(4), 292-297 (2007).
    • (2007) Int. J. Biomed. Sci , vol.3 , Issue.4 , pp. 292-297
    • Arru, G.1    Mameli, G.2    Asone, V.3
  • 61
    • 84866950155 scopus 로고    scopus 로고
    • Expression and activation by Epstein-Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: Inference for multiple sclerosis
    • Mameli G, Poddighe L, Mei A et al. Expression and activation by Epstein-Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis. PLoS ONE 7(9), e44991 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.9
    • Mameli, G.1    Poddighe, L.2    Mei, A.3
  • 62
    • 20144387928 scopus 로고    scopus 로고
    • Human endogenous retrovirus (HERV)-W ENV and GAG proteins: Physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions
    • Perron H, Lazarini F, Ruprecht K et al. Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions. J. Neurovirol. 11(1), 23-33 (2005).
    • (2005) J. Neurovirol , vol.11 , Issue.1 , pp. 23-33
    • Perron, H.1    Lazarini, F.2    Ruprecht, K.3
  • 63
    • 15544378974 scopus 로고    scopus 로고
    • Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    • Antony JM, van Marle G, Opii W et al. Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nat. Neurosci. 7(10), 1088-1095 (2004).
    • (2004) Nat. Neurosci , vol.7 , Issue.10 , pp. 1088-1095
    • Antony, J.M.1    Van Marle, G.2    Opii, W.3
  • 64
    • 84857492022 scopus 로고    scopus 로고
    • Epstein-Barr virus stimulates torque teno virus replication: A possible relationship to multiple sclerosis
    • Borkosky SS, Whitley C, Kopp-Schneider A, zur Hausen H, de Villiers EM. Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis. PLoS ONE 7(2), e32160 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.2
    • Borkosky, S.S.1    Whitley, C.2    Kopp-Schneider, A.3    Zur Hausen, H.4    De Villiers, E.M.5
  • 65
    • 72649104099 scopus 로고    scopus 로고
    • Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain
    • Willis SN, Stadelmann C, Rodig SJ et al. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 132(Pt 12), 3318-3328 (2009).
    • (2009) Brain , vol.132 , Issue.PART 12 , pp. 3318-3328
    • Willis, S.N.1    Stadelmann, C.2    Rodig, S.J.3
  • 66
    • 77951893380 scopus 로고    scopus 로고
    • Epstein-Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis
    • Peferoen LA, Lamers F, Lodder LN et al. Epstein-Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis. Brain 133(Pt 5), e137 (2010).
    • (2010) Brain , vol.133 , Issue.PART 5
    • Peferoen, L.A.1    Lamers, F.2    Lodder, L.N.3
  • 67
    • 77951021143 scopus 로고    scopus 로고
    • Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis
    • Sargsyan SA, Shearer AJ, Ritchie AM et al. Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis. Neurology 74(14), 1127-1135 (2010).
    • (2010) Neurology , vol.74 , Issue.14 , pp. 1127-1135
    • Sargsyan, S.A.1    Shearer, A.J.2    Ritchie, A.M.3
  • 68
    • 84856605958 scopus 로고    scopus 로고
    • Association of innate immune activation with latent Epstein-Barr virus in active MS lesions
    • Tzartos JS, Khan G, Vossenkamper A et al. Association of innate immune activation with latent Epstein-Barr virus in active MS lesions. Neurology 78(1), 15-23 (2012).
    • (2012) Neurology , vol.78 , Issue.1 , pp. 15-23
    • Tzartos, J.S.1    Khan, G.2    Vossenkamper, A.3
  • 70
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • HERMES Trial Group
    • Hauser SL, Waubant E, Arnold DL et al.; HERMES Trial Group. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N. Engl. J. Med. 358(7), 676-688 (2008).
    • (2008) N. Engl. J. Med , vol.358 , Issue.7 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3
  • 71
    • 45749107592 scopus 로고    scopus 로고
    • EBV-associated lymphoproliferative disorders: Classification and treatment
    • Carbone A, Gloghini A, Dotti G. EBV-associated lymphoproliferative disorders: classification and treatment. Oncologist 13(5), 577-585 (2008).
    • (2008) Oncologist , vol.13 , Issue.5 , pp. 577-585
    • Carbone, A.1    Gloghini, A.2    Dotti, G.3
  • 72
    • 84868246228 scopus 로고    scopus 로고
    • Rituximab combination therapy in relapsing multiple sclerosis
    • Cross AH, Klein RS, Piccio L. Rituximab combination therapy in relapsing multiple sclerosis. Ther. Adv. Neurol. Disord. 5(6), 311-319 (2012).
    • (2012) Ther. Adv. Neurol. Disord , vol.5 , Issue.6 , pp. 311-319
    • Cross, A.H.1    Klein, R.S.2    Piccio, L.3
  • 73
    • 0030032317 scopus 로고    scopus 로고
    • Acyclovir treatment of relapsing-remitting multiple sclerosis. A randomized, placebo-controlled, double-blind study
    • Lycke J, Svennerholm B, Hjelmquist E et al. Acyclovir treatment of relapsing-remitting multiple sclerosis. A randomized, placebo-controlled, double-blind study. J. Neurol. 243(3), 214-224 (1996).
    • (1996) J. Neurol , vol.243 , Issue.3 , pp. 214-224
    • Lycke, J.1    Svennerholm, B.2    Hjelmquist, E.3
  • 74
    • 6444244547 scopus 로고    scopus 로고
    • A randomized, double-blind, placebocontrolled MRI study of anti-herpes virus therapy in MS
    • Bech E, Lycke J, Gadeberg P et al. A randomized, double-blind, placebocontrolled MRI study of anti-herpes virus therapy in MS. Neurology 58(1), 31-36 (2002).
    • (2002) Neurology , vol.58 , Issue.1 , pp. 31-36
    • Bech, E.1    Lycke, J.2    Gadeberg, P.3
  • 75
    • 84858233979 scopus 로고    scopus 로고
    • Autoimmune disease: A role for new anti-viral therapies?
    • Dreyfus DH. Autoimmune disease: A role for new anti-viral therapies? Autoimmun. Rev. 11(2), 88-97 (2011).
    • (2011) Autoimmun. Rev , vol.11 , Issue.2 , pp. 88-97
    • Dreyfus, D.H.1
  • 76
    • 39149121505 scopus 로고    scopus 로고
    • Recombinant gp350 vaccine for infectious mononucleosis: A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults
    • Sokal EM, Hoppenbrouwers K, Vandermeulen C et al. Recombinant gp350 vaccine for infectious mononucleosis: a Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults. J. Infect. Dis. 196(12), 1749-1753 (2007).
    • (2007) J. Infect. Dis , vol.196 , Issue.12 , pp. 1749-1753
    • Sokal, E.M.1    Hoppenbrouwers, K.2    Vandermeulen, C.3
  • 77
    • 80455164859 scopus 로고    scopus 로고
    • Epstein-Barr virus: An important vaccine target for cancer prevention
    • Cohen JI, Fauci AS, Varmus H, Nabel GJ. Epstein-Barr virus: an important vaccine target for cancer prevention. Sci. Transl. Med. 3(107), 107fs7 (2011).
    • (2011) Sci. Transl. Med , vol.3 , Issue.107
    • Cohen, J.I.1    Fauci, A.S.2    Varmus, H.3    Nabel, G.J.4
  • 78
    • 80055066029 scopus 로고    scopus 로고
    • Soluble rhesus lymphocryptovirus gp350 protects against infection and reduces viral loads in animals that become infected with virus after challenge
    • Sashihara J, Hoshino Y, Bowman JJ et al. Soluble rhesus lymphocryptovirus gp350 protects against infection and reduces viral loads in animals that become infected with virus after challenge. PLoS Pathog. 7(10), e1002308 (2011).
    • (2011) PLoS Pathog , vol.7 , Issue.10
    • Sashihara, J.1    Hoshino, Y.2    Bowman, J.J.3
  • 79
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation? Proc
    • Hill AB. The environment and disease: association or causation? Proc. R. Soc. Med. 58, 295-300 (1965).
    • (1965) R. Soc. Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 80
    • 33750601736 scopus 로고    scopus 로고
    • Infectious causes of multiple sclerosis
    • Giovannoni G, Cutter GR, Lunemann J et al. Infectious causes of multiple sclerosis. Lancet Neurol. 5(10), 887-894 (2006).
    • (2006) Lancet Neurol , vol.5 , Issue.10 , pp. 887-894
    • Giovannoni, G.1    Cutter, G.R.2    Lunemann, J.3


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