Association between Helicobacter pylori genotypes and severity of chronic gastritis, peptic ulcer disease and gastric mucosal interleukin-8 levels: Evidence from a study in the Middle East

Gut Pathogens

Volumn 6, Issue 1, 2014, Pages

  Siddique, Iqbal ^a,b   Al Qabandi, Asmaa ^a   Al Ali, Jaber ^a   Alazmi, Waleed ^a,b   Memon, Anjum ^c   Mustafa, Abu Salim ^a   Junaid, Thamradeen A ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

^b AL AMIRI HOSPITAL   (Kuwait)

^c BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

Author keywords

cagA; Gastritis; Helicobacter pylori; Interleukin 8; Peptic ulcer disease; vacA s1; vacA s2

Indexed keywords

EID: 84908413434     PISSN: None     EISSN: 17574749     Source Type: Journal    
DOI: 10.1186/s13099-014-0041-1     Document Type: Article

References (48)

1. Eusebi LH, Zagari RM, Bazzoli F: Epidemiology of Helicobacter pylori Infection. Helicobacter 2014, 19(Suppl 1):1-5.
2. Malnick SD, Melzer E, Attali M, Duek G, Yahav J: Helicobacter pylori: Friend or foe? World J Gastroenterol 2014, 20:8979-8985.
3. Marshall BJ, Windsor HM: The relation of Helicobacter pylori to gastric adenocarcinoma and lymphoma: pathophysiology, epidemiology, screening, clinical presentation, treatment, and prevention. Med Clin North Am 2005, 89:313-344.
4. O'Keeffe J, Moran AP: Conventional, regulatory, and unconventional T cells in the immunologic response to helicobacter pylori. Helicobacter 2008, 13:1-19.
5. Basso D, Plebani M, Kusters JG: Pathogenesis of Helicobacter pylori infection. Helicobacter 2010, 15(Suppl 1):14-20.
6. de Bernard M, Josenhans C: Pathogenesis of Helicobacter pylori Infection. Helicobacter 2014, 19(Suppl 1):11-18.
7. Umit H, Tezel A, Bukavaz S, Unsal G, Otkun M, Soylu AR, Tucer D, Otkun M, Bilgi S: The relationship between virulence factors of Helicobacter pylori and severity of gastritis in infected patients. Dig Dis Sci 2009, 54:103-110.
8. Almeida N, Donato MM, Romãozinho JM, Luxo C, Cardoso O, Cipriano MA, Marinho C, Fernandes A, Sofia C: Correlation of helicobacter pylori genotypes with gastric histopathology in the central region of a south-European Country. Dig Dis Sci 2014, [Epub ahead of print].
9. Kim JY, Kim N, Nam RH, Suh JH, Chang H, Lee JW, Kim YS, Kim JM, Choi JW, Park JG, Lee YS, Lee DH, Jung HC: Association of polymorphisms in virulence factor of Helicobacter pylori and gastroduodenal diseases in South Korea. J Gastroenterol Hepatol 2014, 29:984-991.
10. Yamaoka Y, Graham DY: Helicobacter pylori virulence and cancer pathogenesis. Future Oncol 2014, 10:1487-1500.
11. Memon AA, Hussein NR, Miendje Deyi VY, Burette A, Atherton JC: Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study. J Clin Microbiol 2014, 52:2984-2989.
12. Atherton JC, Cao P, Peek RM Jr, Tummuru MK, Blaser MJ, Cover TL: Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995, 270:17771-17777.
13. Rhead JL, Letley DP, Mohammadi M, Hussein N, Mohagheghi MA, Eshagh Hosseini M, Atherton JC: A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 2007, 133:926-936.
14. Matos JI, de Sousa HA, Marcos-Pinto R, Dinis-Ribeiro M: Helicobacter pylori CagA and VacA genotypes and gastric phenotype: a meta-analysis. Eur J Gastroenterol Hepatol 2013, 25:1431-1441.
15. Bodger K, Bromelow K, Wyatt JI, Heatley RV: Interleukin 10 in Helicobacter pylori associated gastritis: immunohistochemical localisation and in vitro effects on cytokine secretion. J Clin Pathol 2001, 54:285-292.
16. Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yahiro K, Moss J, Hirayama T: Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation. J Immunol 2008, 180:5017-5027.
17. Lee KE, Khoi PN, Xia Y, Park JS, Joo YE, Kim KK, Choi SY, Jung YD: Helicobacter pylori and interleukin-8 in gastric cancer. World J Gastroenterol 2013, 19:8192-8202.
18. Audibert C, Janvier B, Grignon B, Salaün L, Burucoa C, Lecron JC, Fauchère JL: Correlation between IL-8 induction, cagA status and vacA genotypes in 153 French Helicobacter pylori isolates. Res Microbiol 2000, 151:191-200.
19. Bartchewsky W Jr, Martini MR, Masiero M, Squassoni AC, Alvarez MC, Ladeira MS, Salvatore D, Trevisan M, Pedrazzoli J Jr, Ribeiro ML: Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. Scand J Gastroenterol 2009, 44:153-161.
20. Soltermann A, Koetzer S, Eigenmann F, Komminoth P: Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age. Mod Pathol 2007, 20:878-883.
21. Gunn MC, Stephens JC, Stewart JA, Rathbone BJ, West KP: The significance of cagA and vacA subtypes of Helicobacter pylori in the pathogenesis of inflammation and peptic ulceration. J Clin Pathol 1998, 51:761-764.
22. Demirtürk L, Ozel AM, Yazgan Y, Solmazgül E, Yildirim S, Gültepe M, Gürbüz AK: CagA status in dyspeptic patients with and without peptic ulcer disease in Turkey: association with histopathologic findings. Helicobacter 2001, 6:163-168.
23. Saruc¸ M, Demir MA, Küc¸ükmetin N, Kandiloglu AR, Akarca US, Yüceyar H: Histological and clinical predictive value of determination of tissue CagA status by PCR in Helicobacter pylori infected patients; results of the large population based study in western Turkey. Hepatogastroenterology 2002, 49:878-881.
24. Warburton VJ, Everett S, Mapstone NP, Axon AT, Hawkey P, Dixon MF: Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis. J Clin Pathol 1998, 51:55-61.
25. Atherton JC, Peek RM Jr, Tham KT, Cover TL, Blaser MJ: Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997, 112:92-99.
26. Al Qabandi A, Mustafa AS, Siddique I, Khajah AK, Madda JP, Junaid TA: Distribution of vacA and cagA genotypes of Helicobacter pylori in Kuwait. Acta Trop 2005, 93:283-288.
27. Albert MJ, Al-Akbal HM, Dhar R, De R, Mukhopadhyay AK: Genetic affinities of Helicobacter pylori isolates from ethnic Arabs in Kuwait. Gut Pathog 2010, 2:6.
28. Ma YJ, Duan GC, Zhang RG, Fan QT, Zhang WD: Mutation of iceA in Helicobacter pylori compromised IL-8 induction from human gastric epithelial cells. J Basic Microbiol 2010, 50(Suppl 1):S83-S88.
29. Naito M, Eguchi H, Goto Y, Kondo T, Nishio K, Ishida Y, Kawai S, Okada R, Hishida A, Wakai K, Hamajima N: Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes. Epidemiol Infect 2010, 138:512-518.
30. Noach LA, Bosma NB, Jansen J, Hoek FJ, van Deventer SJ, Tytgat GN: Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection. Scand J Gastroenterol 1994, 29:425-429.
31. Peek RM Jr, Miller GG, Tham KT, Perez-Perez GI, Zhao X, Atherton JC, Blaser MJ: Heightened inflammatory response and cytokine expression in vivo to cagA + Helicobacter pylori strains. Lab Invest 1995, 73:760-770.
32. Siddique I, Al-Mekhaizeem K, Alateeqi N, Memon A, Hasan F: Diagnosis of Helicobacter pylori: improving the sensitivity of CLOtest by increasing the number of gastric antral biopsies. J Clin Gastroenterol 2008, 42:356-360.
33. Alam J, Maiti S, Ghosh P, De R, Chowdhury A, Das S, Macaden R, Devarbhavi H, Ramamurthy T, Mukhopadhyay AK: Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population. J Med Microbiol 2012, 61:1295-1302.
34. Höcker M, Hohenberger P: Helicobacter pylori virulence factors-one part of a big picture. Lancet 2003, 362:1231-1233.
35. Varon C, Mosnier JF, Lehours P, Matysiak-Budnik T, Mégraud F: Gastric carcinogenesis and Helicobacter pylori infection. Methods Mol Biol 2009, 511:237-265.
36. Wex T, Bornschein J, Malfertheiner P: Host polymorphisms of immune regulatory genes as risk factors for gastric cancer. Minerva Gastroenterol Dietol 2009, 55:395-408.
37. Lanas A, García-González MA, Santolaria S, Crusius JB, Serrano MT, Benito R, Peña AS: TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients. Genes Immun 2001, 2:415-421.
38. The European Society of Gastrointestinal Endoscopy: Guidelines on cleaning and disinfection in GI endoscopy. Update 1999. Endoscopy 2000, 32:77-80.
39. Doglioni C, Turrin M, Macrì E, Chiarelli C, Germanà B, Barbareschi M: HpSS: a new silver staining method for Helicobacter pylori. J Clin Pathol 1997, 50:461-464.
40. Dixon MF, Genta RM, Yardley JH, Correa P: Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996, 20:1161-1181.
41. van Doorn LJ, Figueiredo C, Sanna R, Plaisier A, Schneeberger P, de Boer W, Quint W: Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology 1998, 115:58-66.
42. van Doorn LJ, Figueiredo C, Rossau R, Jannes G, van Asbroek M, Sousa JC, Carneiro F, Quint WG: Typing of Helicobacter pylori vacA gene and detection of cagA gene by PCR and reverse hybridization. J Clin Microbiol 1998, 36:1271-1276.
43. De Gusmão VR, Nogueira Mendes E, De Magalhães Queiroz DM, Aguiar Rocha G, Camargos Rocha AM, Ramadan Ashour AA, Teles Carvalho AS: vacA genotypes in Helicobacter pylori strains isolated from children with and without duodenal ulcer in Brazil. J Clin Microbiol 2000, 38:2853-2857.
44. Mustafa AS, Ahmed A, Abal AT, Chugh TD: Establishment and evaluation of a multiplex polymerase chain reaction for detection of mycobacteria and specific identification of Mycobacterium tuberculosis complex. Tuber Lung Dis 1995, 76:336-343.
45. Yamaoka Y, Kita M, Kodama T, Sawai N, Kashima K, Imanishi J: Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut 1997, 41:442-451.
46. Zhang QB, Etolhi G, Dawodu JB, Husain A, Gemmell CG, Russell RI: Relationship between mucosal levels of interleukin 8 and toxinogenicity of Helicobacter pylori. Inflammopharmacology 1998, 6:109-117.
47. Yamamoto S, Kaneko H, Konagaya T, Mori S, Kotera H, Hayakawa T, Yamaguchi C, Uruma M, Kusugami K, Mitsuma T: Interactions among gastric somatostatin, interleukin-8 and mucosal inflammation in Helicobacter pylori-positive peptic ulcer patients. Helicobacter 2001, 6:136-145.
48. Noble JE, Bailey MJ: Quantitation of protein. Methods Enzymol 2009, 463:73-95.