Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population

Journal of Medical Microbiology

Volumn 61, Issue PART 9, 2012, Pages 1295-1302

  Alam, Jawed ^a   Maiti, Sankar ^b   Ghosh, Prachetash ^a   De, Ronita ^a   Chowdhury, Abhijit ^c   Das, Suryasnata ^d   Macaden, Ragini ^d   Devarbhavi, Harshad ^d   Ramamurthy, T ^a   Mukhopadhyay, Asish K ^a  

^a NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

^b INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH KOLKATA   (India)

^c INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^d ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; DUPA PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; AGED; AMERICAN INDIAN; ARTICLE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIUM ISOLATION; DOT HYBRIDIZATION; DUODENUM ULCER; DYSPEPSIA; FEMALE; GENE EXPRESSION; GENE INSERTION; GENE SEQUENCE; HELICOBACTER PYLORI; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PREDICTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

ADULT; AGED; BASE SEQUENCE; DUODENAL ULCER; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INDIA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; VIRULENCE FACTORS; YOUNG ADULT;

EID: 84865165346     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.038398-0     Document Type: Article

References (45)

1. Alm, R. A., Ling, L. S., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C. & other authors (1999). Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397, 176-180.
2. Arachchi, H. S., Kalra, V., Lal, B., Bhatia, V., Baba, C. S., Chakravarthy, S., Rohatgi, S., Sarma, P. M., Mishra, V. & other authors (2007). Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter 12, 591-597.
3. Argent, R. H., Burette, A., Miendje Deyi, V. Y. & Atherton, J. C. (2007). The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin Infect Dis 45, 1204-1206.
4. Atherton, J. C., Cao, P., Peek, R. M., Jr, Tummuru, M. K. R., Blaser, M. J. & Cover, T. L. (1995). Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270, 17771-17777.
5. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1993). Current Protocols in Molecular Biology. New York: Greene Publishing and Wiley-Interscience.
6. Broutet, N., Marais, A., Lamouliatte, H., de Mascarel, A., Samoyeau, R., Salamon, R. & Mégraud, F. (2001). cagA Status and eradication treatment outcome of anti-Helicobacter pylori triple therapies in patients with nonulcer dyspepsia. J ClinMicrobiol 39, 1319-1322.
7. Brown, L. M. (2000). Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 22, 283-297.
8. Censini, S., Lange, C., Xiang, Z., Crabtree, J. E., Ghiara, P., Borodovsky, M., Rappuoli, R. & Covacci, A. (1996). Cag, pathogenicity island of Helicobacter pylori, encodes type I-specific and diseases associated virulence factors. Proc Natl Acad Sci USA 93, 14648-14653.
9. Chattopadhyay, S., Patra, R., Ramamurthy, T., Chowdhury, A., Santra, A., Dhali, G. K., Bhattacharya, S. K., Berg, D. E., Nair, G. B. & Mukhopadhyay, A. K. (2004). Multiplex PCR assay for rapid detection and genotyping of Helicobacter pylori directly from biopsy specimens. J Clin Microbiol 42, 2821-2824.
10. Covacci, A., Censini, S., Bugnoli, M., Petracca, R., Burroni, D., Macchia, G., Massone, A., Papini, E., Xiang, Z. & other authors (1993). Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci U S A 90, 5791-5795.
11. Czinn, S. J. (2005). Helicobacter pylori infection: detection, investigation, and management. J Pediatr 146 (Suppl. 3), S21-S26.
12. De Jonge, R., Kuipers, E. J., Langeveld, S. C., Loffeld, R. J., Stoof, J., van Vliet, A. H. & Kusters, J. G. (2004). The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells. FEMS Immunol Med Microbiol 41, 161-167.
13. Douraghi, M., Mohammadi, M., Oghalaie, A., Abdirad, A., Mohagheghi, M. A., Hosseini, M. E., Zeraati, H., Ghasemi, A., Esmaieli, M. & Mohajerani, N. (2008). dupA as a risk determinant in Helicobacter pylori infection. J Med Microbiol 57, 554-562.
14. El-Omar, E. M., Carrington, M., Chow, W.-H., McColl, K. E., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C.-C. & other authors (2000). Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404, 398-402.
15. Gomes, L. I., Rocha, G. A., Rocha, A. M., Soares, T. F., Oliveira, C. A., Bittencourt, P. F. & Queiroz, D. M. (2008). Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients. Int J Med Microbiol 298, 223-230.
16. Graham, D. Y., Adam, E., Reddy, G. T., Agarwal, J. P., Agarwal, R., Evans, D. J., Jr, Malaty, H. M. & Evans, D. G. (1991). Seroepidemiology of Helicobacter pylori infection in India. Comparison of developing and developed countries. Dig Dis Sci 36, 1084-1088.
17. Hussein, N. R. (2010). The association of dupA and Helicobacter pylori-related gastroduodenal diseases. Eur J Clin Microbiol Infect Dis 29, 817-821.
18. Hussein, N. R., Mohammadi, M., Talebkhan, Y., Doraghi, M., Letley, D. P., Muhammad, M. K., Argent, R. H. & Atherton, J. C. (2008). Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease. J Clin Microbiol 46, 1774-1779.
19. Jung, S. W., Sugimoto, M., Shiota, S., Graham, D. Y. & Yamaoka, Y. (2012). The intact dupA cluster is a more reliable Helicobacter pylori virulence marker than dupA alone. Infect Immun 80, 381-387.
20. Kersulyte, D., Velapatiño, B., Mukhopadhyay, A. K., Cahuayme, L., Bussalleu, A., Combe, J., Gilman, R. H. & Berg, D. E. (2003). Cluster of type IV secretion genes in Helicobacter pylori's plasticity zone. J Bacteriol 185, 3764-3772.
21. Lu, H., Hsu, P.-I., Graham, D. Y. & Yamaoka, Y. (2005). Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology 128, 833-848.
22. Machado, J. C., Pharoah, P., Sousa, S., Carvalho, R., Oliveira, C., Figueiredo, C., Amorim, A., Seruca, R., Caldas, C. & other authors (2001). Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 121, 823-829.
23. Mégraud, F. & Lamouliatte, H. (1992). Helicobacter pylori and duodenal ulcer. Evidence suggesting causation. Dig Dis Sci 37, 769-772.
24. Moura, S. B., Costa, R. F. A., Anacleto, C., Rocha, G. A., Rocha, A. M. C. & Queiroz, D. M. M. (2012). Single nucleotide polymorphisms of Helicobacter pylori dupA that lead to premature stop codons. Helicobacter 17, 176-180.
25. Mukhopadhyay, A. K., Kersulyte, D., Jeong, J. Y., Datta, S., Ito, Y., Chowdhury, A., Chowdhury, S., Santra, A., Bhattacharya, S. K. & other authors (2000). Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India. J Bacteriol 182, 3219-3227.
26. Nguyen, L. T., Uchida, T., Tsukamoto, Y., Kuroda, A., Okimoto, T., Kodama, M., Murakami, K., Fujioka, T. & Moriyama, M. (2010). Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population. Clin Microbiol Infect 16, 1264-1269.
27. Occhialini, A., Marais, A., Alm, R., Garcia, F., Sierra, R. & Mégraud, F. (2000). Distribution of open reading frames of plasticity region of strain J99 in Helicobacter pylori strains isolated from gastric carcinoma and gastritis patients in Costa Rica. Infect Immun 68, 6240-6249.
28. Pacheco, A. R., Proença-Módena, J. L., Sales, A. I., Fukuhara, Y., da Silveira, W. D., Pimenta-Módena, J. L., de Oliveira, R. B. & Brocchi, M. (2008). Involvement of the Helicobacter pylori plasticity region and cag pathogenicity island genes in the development of gastroduodenal diseases. Eur J Clin Microbiol Infect Dis 27, 1053-1059.
29. Parsonnet, J., Friedman, G. D., Vandersteen, D. P., Chang, Y., Vogelman, J. H., Orentreich, N. & Sibley, R. K. (1991). Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325, 1127-1131.
30. Patra, R., Chattopadhyay, S., De, R., Datta, S., Chowdhury, A., Ramamurthy, T., Nair, G. B., Berg, D. E. & Mukhopadhyay, A. K. (2011). Intact cag pathogenicity island of Helicobacter pylori without disease association in Kolkata, India. Int J Med Microbiol 301, 293-302.
31. Queiroz, D. M., Rocha, G. A., Rocha, A. M., Moura, S. B., Saraiva, I. E., Gomes, L. I., Soares, T. F., Melo, F. F., Cabral, M. M. & Oliveira, C. A. (2011). dupA polymorphisms and risk of Helicobacter pyloriassociated diseases. Int J Med Microbiol 301, 225-228.
32. Rahman, M., Mukhopadhyay, A. K., Nahar, S., Datta, S., Ahmad, M. M., Sarker, S., Masud, I. M., Engstrand, L., Albert, M. J. & other authors (2003). DNA-level characterization of Helicobacter pylori strains from patients with overt disease and with benign infections in Bangladesh. J Clin Microbiol 41, 2008-2014.
33. Rocha, G. A., Guerra, J. B., Rocha, A. M., Saraiva, I. E., da Silva, D. A., de Oliveira, C. A. & Queiroz, D. M. (2005). IL1RN polymorphic gene and cagA-positive status independently increase the risk of noncardia gastric carcinoma. Int J Cancer 115, 678-683.
34. Santos, A., Queiroz, D. M., Ménard, A., Marais, A., Rocha, G. A., Oliveira, C. A., Nogueira, A. M., Uzeda, M. & Mégraud, F. (2003). New pathogenicity marker found in the plasticity region of the Helicobacter pylori genome. J Clin Microbiol 41, 1651-1655.
35. Schmidt, H. M., Andres, S., Kaakoush, N. O., Engstrand, L., Eriksson, L., Goh, K. L., Fock, K. M., Hilmi, I. D., Dhamodaran, S. & other authors (2009). The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case control study. Gut Pathog 1, 5.
36. Shiota, S., Matsunari, O., Watada, M., Hanada, K. & Yamaoka, Y. (2010). Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes. Gut Pathog 2, 13.
37. Singh, V., Trikha, B., Nain, C. K., Singh, K. & Vaiphei, K. (2002). Epidemiology of Helicobacter pylori and peptic ulcer in India. J Gastroenterol Hepatol 17, 659-665.
38. Tomb, J. F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S. & other authors (1997). The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539-547.
39. Wotherspoon, A. C., Ortiz-Hidalgo, C., Falzon, M. R. & Isaacson, P. G. (1991). Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 338, 1175-1176.
40. Yakoob, J., Abbas, Z., Naz, S., Islam, M., Abid, S. & Jafri, W. (2010). Associations between the plasticity region genes of Helicobacter pylori and gastroduodenal diseases in a high-prevalence area. Gut Liver 4, 345-350.
41. Yamaoka, Y., El-Zimaity, H. M. T., Gutierrez, O., Figura, N., Kim, J. G., Kodama, T., Kashima, K. & Graham, D. Y. (1999). Relationship between the cagA 39 repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH. Gastroenterology 117, 342-349.
42. r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori. Proc Natl Acad Sci U S A 97, 7533-7538.
43. Yamaoka, Y., Kikuchi, S., el-Zimaity, H. M. T., Gutierrez, O., Osato, M. S. & Graham, D. Y. (2002). Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production. Gastroenterology 123, 414-424.
44. Yamaoka, Y. (2008). Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis. J Med Microbiol 57, 545-553.
45. Zhang, Z., Zheng, Q., Chen, X., Xiao, S., Liu, W. & Lu, H. (2008). The Helicobacter pylori duodenal ulcer promoting gene, dupA in China. BMC Gastroenterol 8, 49.