Helicobacter pylori: Friend or foe?

World Journal of Gastroenterology

Volumn , Issue 27, 2014, Pages 8979-8985

  Malnick, Stephen David Howard ^a   Melzer, Ehud ^a   Attali, Malka ^a   Duek, Gabriel ^a   Yahav, Jacob ^b  

^a KAPLAN MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Benefit; Cancer; Cost; Helicobacter pylori; Treatment

Indexed keywords

AMOXICILLIN; BISMUTH SALICYLATE; CLARITHROMYCIN; METRONIDAZOLE; OMEPRAZOLE; TETRACYCLINE; ANTIINFECTIVE AGENT;

BACTERIAL CLEARANCE; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; CYANOCOBALAMIN DEFICIENCY; DISEASE ASSOCIATION; DYSPEPSIA; ESOPHAGEAL ADENOCARCINOMA; GASTROESOPHAGEAL REFLUX; HEALTH CARE COST; HELICOBACTER INFECTION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IRON DEFICIENCY ANEMIA; MARGINAL ZONE LYMPHOMA; MICROBIOME; PEPTIC ULCER; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STOMACH CANCER; STOMACH CARCINOMA; SYSTEMATIC REVIEW (TOPIC); THROMBOCYTOPENIA; ADENOCARCINOMA; ANTIBIOTIC RESISTANCE; DRUG COST; DRUG EFFECTS; ECONOMICS; ESOPHAGEAL NEOPLASMS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOST PATHOGEN INTERACTION; HUMAN; MICROBIOLOGY; MICROFLORA; PATHOGENICITY; PROTECTION; RISK FACTOR; STOMACH; STOMACH NEOPLASMS; TREATMENT OUTCOME;

ADENOCARCINOMA; ANTI-BACTERIAL AGENTS; COST-BENEFIT ANALYSIS; DRUG COSTS; DRUG RESISTANCE, BACTERIAL; ESOPHAGEAL NEOPLASMS; GASTROESOPHAGEAL REFLUX; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOST-PATHOGEN INTERACTIONS; HUMANS; MICROBIOTA; PEPTIC ULCER; PROTECTIVE FACTORS; RISK FACTORS; STOMACH; STOMACH NEOPLASMS; TREATMENT OUTCOME;

EID: 84905375850     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i27.8979     Document Type: Review

References (69)

1. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1: 1311-1315 [PMID: 6145023]
2. Everhart JE. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterol Clin North Am 2000; 29: 559-578 [PMID: 11030073]
3. Woodward M, Morrison C, McColl K. An investigation into factors associated with Helicobacter pylori infection. J Clin Epidemiol 2000; 53: 175-181 [PMID: 10729690]
4. McColl KE. Clinical practice. Helicobacter pylori infection. N Engl J Med 2010; 362: 1597-1604 [PMID: 20427808 DOI: 10.1056/NEJMcp1001110]
5. Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ. Management of Helicobacter pylori infection - the Maastricht IV/ Florence Consensus Report. Gut 2012; 61: 646-664 [PMID: 22491499 DOI: 10.1136/gutjnl-2012-302084]
6. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347: 1175-1186 [PMID: 12374879 DOI: 10.1056/NEJMra020542]
7. Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther 1995; 9 Suppl 2: 33-39 [PMID: 8547526]
8. Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med 1996; 100: 12S-17S; discussion 17S-18S [PMID: 8644777]
9. Mégraud F. Transmission of Helicobacter pylori: faecal-oral versus oral-oral route. Aliment Pharmacol Ther 1995; 9 Suppl 2: 85-91 [PMID: 8547533]
10. Webb PM, Knight T, Greaves S, Wilson A, Newell DG, Elder J, Forman D. Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life. BMJ 1994; 308: 750-753 [PMID: 8142828]
11. Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T, Miki K, Graham DY. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 1992; 102: 760-766 [PMID: 1537513]
12. Archimandritis A, Balatsos V, Delis V, Manika Z, Skandalis N. "Reappearance" of Helicobacter pylori after eradication: implications on duodenal ulcer recurrence: a prospective 6 year study. J Clin Gastroenterol 1999; 28: 345-347 [PMID: 10372933]
13. Parsonnet J. The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther 1995; 9 Suppl 2: 45-51 [PMID: 8547528]
14. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA 1994; 272: 65-69 [PMID: 8007082]
15. Chey WD, Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol 2007; 102: 1808-1825 [PMID: 17608775 DOI: 10.1111/j.1572-0241.2007.01393.x]
16. Laine L. Helicobacter pylori, gastric ulcer, and agents noxious to the gastric mucosa. Gastroenterol Clin North Am 1993; 22: 117-125 [PMID: 8449561]
17. DuBois S, Kearney DJ. Iron-deficiency anemia and Helicobacter pylori infection: a review of the evidence. Am J Gastroenterol 2005; 100: 453-459 [PMID: 15667507 DOI: 10.1111/j.1572-0241.2005.30252.x]
18. Kaptan K, Beyan C, Ural AU, Cetin T, Avcu F, Gülşen M, Finci R, Yalc¸ín A. Helicobacter pylori - is it a novel causative agent in Vitamin B12 deficiency? Arch Intern Med 2000; 160: 1349-1353 [PMID: 10809040]
19. Papagiannakis P, Michalopoulos C, Papalexi F, Dalampoura D, Diamantidis MD. The role of Helicobacter pylori infection in hematological disorders. Eur J Intern Med 2013; 24: 685-690 [PMID: 23523153 DOI: 10.1016/j.ejim.2013.02.011]
20. An international association between Helicobacter pylori infection and gastric cancer. The EUROGAST Study Group. Lancet 1993; 341: 1359-1362 [PMID: 8098787]
21. Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991; 325: 1132-1136 [PMID: 1891021 DOI: 10.1056/NEJM199110173251604]
22. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991; 338: 1175-1176 [PMID: 1682595]
23. Howden CW, Hunt RH. Guidelines for the management of Helicobacter pylori infection. Ad Hoc Committee on Practice Parameters of the American College of Gastroenterology. Am J Gastroenterol 1998; 93: 2330-2338 [PMID: 9860388 DOI: 10.1111/j.1572-0241.1998.00684.x]
24. Feldman M, Cryer B, Lee E, Peterson WL. Role of seroconversion in confirming cure of Helicobacter pylori infection. JAMA 1998; 280: 363-365 [PMID: 9686554]
25. Trevisani L, Sartori S, Ruina M, Caselli M, Rossi MR, Costa F, Bellini M, Iaquinto G, Gardullo N, Todisco A. Helicobacter pylori stool antigen test: clinical evaluation and cost analysis of a new enzyme immunoassay. Dig Dis Sci 1999; 44: 2303-2306 [PMID: 10573378]
26. Bytzer P, Teglbjaerg PS; Danish Ulcer Study Group. Helicobacter pylori-negative duodenal ulcers: prevalence, clinical characteristics, and prognosis - results from a randomized trial with 2-year follow-up. Am J Gastroenterol 2001; 96: 1409-1416 [PMID: 11374675 DOI: 10.1111/j.1572-0241.2001.03774.x]
27. Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001; 49: 347-353 [PMID: 11511555]
28. Sotoudeh M, Derakhshan MH, Abedi-Ardakani B, Nouraie M, Yazdanbod A, Tavangar SM, Mikaeli J, Merat S, Malekzadeh R. Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer. Dig Dis Sci 2008; 53: 27-33 [PMID: 17492381 DOI: 10.1007/s10620-007-9817-1]
29. Graham DY, Shiotani A. The time to eradicate gastric cancer is now. Gut 2005; 54: 735-738 [PMID: 15888771 DOI: 10.1136/gut.2004.056549]
30. Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, Lai KC, Hu WH, Yuen ST, Leung SY, Fong DY, Ho J, Ching CK, Chen JS. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 2004; 291: 187-194 [PMID: 14722144 DOI: 10.1001/jama.291.2.187]
31. Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S, Terao S, Amagai K, Hayashi S, Asaka M. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet 2008; 372: 392-397 [PMID: 18675689 DOI: 10.1016/S0140-6736(08)61159-9]
32. Zhou LY, Lin SR, Ding SG, Huang XB, Zhang L, Meng LM, Cui RL, Zhu J. The changing trends of the incidence of gastric cancer after Helicobacter pylori eradication in Shandong area. Chin J Dig Dis 2005; 6: 114-115 [PMID: 16045599 DOI: 10.1111/j.1443-9573.2005.00204.x]
33. Mera R, Fontham ET, Bravo LE, Bravo JC, Piazuelo MB, Camargo MC, Correa P. Long term follow up of patients treated for Helicobacter pylori infection. Gut 2005; 54: 1536-1540 [PMID: 15985559 DOI: 10.1136/gut.2005.072009]
34. Ito M, Haruma K, Kamada T, Mihara M, Kim S, Kitadai Y, Sumii M, Tanaka S, Yoshihara M, Chayama K. Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis. Aliment Pharmacol Ther 2002; 16: 1449-1456 [PMID: 12182744]
35. Sung JJ, Lin SR, Ching JY, Zhou LY, To KF, Wang RT, Leung WK, Ng EK, Lau JY, Lee YT, Yeung CK, Chao W, Chung SC. Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology 2000; 119: 7-14 [PMID: 10889149]
36. Fuccio L, Zagari RM, Eusebi LH, Laterza L, Cennamo V, Ceroni L, Grilli D, Bazzoli F. Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? Ann Intern Med 2009; 151: 121-128 [PMID: 19620164]
37. Maehata Y, Nakamura S, Fujisawa K, Esaki M, Moriyama T, Asano K, Fuyuno Y, Yamaguchi K, Egashira I, Kim H, Kanda M, Hirahashi M, Matsumoto T. Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. Gastrointest Endosc 2012; 75: 39-46 [PMID: 22018552 DOI: 10.1016/j.gie.2011.08.030]
38. Yanaoka K, Oka M, Ohata H, Yoshimura N, Deguchi H, Mukoubayashi C, Enomoto S, Inoue I, Iguchi M, Maekita T, Ueda K, Utsunomiya H, Tamai H, Fujishiro M, Iwane M, Takeshita T, Mohara O, Ichinose M. Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels. Int J Cancer 2009; 125: 2697-2703 [PMID: 19610064 DOI: 10.1002/ijc.24591]
39. Talley NJ; American Gastroenterological Association. American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology 2005; 129: 1753-1755 [PMID: 16285970 DOI: 10.1053/j.gastro.2005.09.019]
40. Mazzoleni LE, Sander GB, Francesconi CF, Mazzoleni F, Uchoa DM, De Bona LR, Milbradt TC, Von Reisswitz PS, Berwanger O, Bressel M, Edelweiss MI, Marini SS, Molina CG, Folador L, Lunkes RP, Heck R, Birkhan OA, Spindler BM, Katz N, Colombo Bda S, Guerrieri PP, Renck LB, Grando E, Hocevar de Moura B, Dahmer FD, Rauber J, Prolla JC. Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Arch Intern Med 2011; 171: 1929-1936 [PMID: 22123802 DOI: 10.1001/archinternmed.2011.533]
41. Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M, Oakes R, Wilson S, Roalfe A, Bennett C, Forman D. Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev 2005; (1): CD002096 [PMID: 15674892 DOI: 10.1002/14651858.CD002096.pub2]
42. Mearin F, Pérez-Oliveras M, Perelló A, Vinyet J, Ibañez A, Coderch J, Perona M. Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study. Gastroenterology 2005; 129: 98-104 [PMID: 16012939]
43. Ford AC, Thabane M, Collins SM, Moayyedi P, Garg AX, Clark WF, Marshall JK. Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study. Gastroenterology 2010; 138: 1727-1736; quiz e12 [PMID: 20117111 DOI: 10.1053/j.gastro.2010.01.043]
44. Moayyedi P. Helicobacter pylori eradication for functional dyspepsia: what are we treating?: comment on "Helicobacter pylori eradication in functional dyspepsia". Arch Intern Med 2011; 171: 1936-1937 [PMID: 22123803 DOI: 10.1001/archinternmed.2011.541]
45. Malfertheiner P, Venerito M, Selgrad M. Helicobacter pylori infection: selected aspects in clinical management. Curr Opin Gastroenterol 2013; 29: 669-675 [PMID: 24100726 DOI: 10.1097/MOG.Ob012e328365d443]
46. Linz B, Balloux F, Moodley Y, Manica A, Liu H, Roumagnac P, Falush D, Stamer C, Prugnolle F, van der Merwe SW, Yamaoka Y, Graham DY, Perez-Trallero E, Wadstrom T, Suerbaum S, Achtman M. An African origin for the intimate association between humans and Helicobacter pylori. Nature 2007; 445: 915-918 [PMID: 17287725 DOI: 10.1038/nature05562]
47. Sonnenberg A, Lash RH, Genta RM. A national study of Helicobactor pylori infection in gastric biopsy specimens. Gastroenterology 2010; 139: 1894-1901.e2; quiz e12 [PMID: 20727889 DOI: 10.1053/j.gastro.2010.08.018]
48. Shaheen N, Ransohoff DF. Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review. JAMA 2002; 287: 1972-1981 [PMID: 11960540]
49. Lagergren J, Bergström R, Lindgren A, Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825-831 [PMID: 10080844 DOI: 10.1056/NEJM199903183401101]
50. Devesa SS, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998; 83: 2049-2053 [PMID: 9827707]
51. Pohl H, Welch HG. The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst 2005; 97: 142-146 [PMID: 15657344 DOI: 10.1093/jnci/dji024]
52. Bollschweiler E, Wolfgarten E, Gutschow C, Hölscher AH. Demographic variations in the rising incidence of esophageal adenocarcinoma in white males. Cancer 2001; 92: 549-555 [PMID: 11505399]
53. Bresalier RS. Barrett's Esophagus and esophageal adenocarcinoma. Annu Rev Med 2009; 60: 221-231 [PMID: 18783330 DOI: 10.1146/annurev.med.59.061206.112706]
54. Atherton JC, Blaser MJ. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest 2009; 119: 2475-2487 [PMID: 19729845 DOI: 10.1172/JCI38605]
55. Chen Y, Blaser MJ. Helicobacter pylori colonization is inversely associated with childhood asthma. J Infect Dis 2008; 198: 553-560 [PMID: 18598192 DOI: 10.1086/590158]
56. Segal I, Otley A, Issenman R, Armstrong D, Espinosa V, Cawdron R, Morshed MG, Jacobson K. Low prevalence of Helicobacter pylori infection in Canadian children: a cross-sectional analysis. Can J Gastroenterol 2008; 22: 485-489 [PMID: 18478134]
57. Rothenbacher D, Bode G, Berg G, Gommel R, Gonser T, Adler G, Brenner H. Prevalence and determinants of Helicobacter pylori infection in preschool children: a population-based study from Germany. Int J Epidemiol 1998; 27: 135-141 [PMID: 9563707]
58. Chen Y, Blaser MJ. Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med 2007; 167: 821-827 [PMID: 17452546 DOI: 10.1001/archinte.167.8.821]
59. Janson C, Asbjornsdottir H, Birgisdottir A, Sigurjonsdottir RB, Gunnbjörnsdottir M, Gislason D, Olafsson I, Cook E, Jögi R, Gislason T, Thjodleifsson B. The effect of infectious burden on the prevalence of atopy and respiratory allergies in Iceland, Estonia, and Sweden. J Allergy Clin Immunol 2007; 120: 673-679 [PMID: 17586034 DOI: 10.1016/j.jaci.2007.05.003]
60. Rothenbacher D, Blaser MJ, Bode G, Brenner H. Inverse relationship between gastric colonization of Helicobacter pylori and diarrheal illnesses in children: results of a population-based cross-sectional study. J Infect Dis 2000; 182: 1446-1449 [PMID: 11015236 DOI: 10.1086/315887]
61. Chang AH, Haggerty TD, de Martel C, Leung CW, Parsonnet J. Effect of Helicobacter pylori infection on symptoms of gastroenteritis due to enteropathogenic Escherichia coli in adults. Dig Dis Sci 2011; 56: 457-464 [PMID: 20635147 DOI: 10.1007/s10620-010-1309-z]
62. Pflughoeft KJ, Versalovic J. Human microbiome in health and disease. Annu Rev Pathol 2012; 7: 99-122 [PMID: 21910623 DOI: 10.1146/annurev-pathol-011811-132421]
63. Stecher B, Maier L, Hardt WD. 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution. Nat Rev Microbiol 2013; 11: 277-284 [PMID: 23474681 DOI: 10.1038/nrmicro2989]
64. Briggs AH, Sculpher MJ, Logan RP, Aldous J, Ramsay ME, Baron JH. Cost effectiveness of screening for and eradication of Helicobacter pylori in management of dyspeptic patients under 45 years of age. BMJ 1996; 312: 1321-1325 [PMID: 8646042]
65. Parsonnet J, Harris RA, Hack HM, Owens DK. Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials. Lancet 1996; 348: 150-154 [PMID: 8684154]
66. Mason J, Axon AT, Forman D, Duffett S, Drummond M, Crocombe W, Feltbower R, Mason S, Brown J, Moayyedi P. The cost-effectiveness of population Helicobacter pylori screening and treatment: a Markov model using economic data from a randomized controlled trial. Aliment Pharmacol Ther 2002; 16: 559-568 [PMID: 11876711]
67. Roderick P, Davies R, Raftery J, Crabbe D, Pearce R, Bhandari P, Patel P. The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model. Health Technol Assess 2003; 7: 1-86 [PMID: 12709294]
68. Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy in Helicobacter pylori positive peptic ulcer disease: systematic review and economic analysis. Am J Gastroenterol 2004; 99: 1833-1855 [PMID: 15330927 DOI: 10.1111/j.1572-0241.2004.40014.x]
69. Leivo T, Salomaa A, Kosunen TU, Tuominen R, Färkkilä M, Linna M, Sintonen H. Cost-benefit analysis of Helicobacter pylori screening. Health Policy 2004; 70: 85-96 [PMID: 15312711 DOI: 10.1016/j.healthpol.2004.02.004]