TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients

Genes and Immunity

Volumn 2, Issue 8, 2001, Pages 415-421

  Lanas, A ^a   Garcia Gonzalez M A ^a,b   Santolaria, S ^a   Crusius, J B A ^b   Serrano, M T ^a   Benito, R ^a   Pena A S ^b  

^a HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Duodenal ulcer; Gastric ulcer; Gene polymorphism; Helicobacter pylori; Peptic ulcer; Tumour necrosis factor

Indexed keywords

HELICOBACTER PYLORI;

LYMPHOTOXIN; PEPTIDE FRAGMENT; TUMOR NECROSIS FACTOR (1 26); TUMOR NECROSIS FACTOR (1-26); TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; CASE CONTROL STUDY; DEMOGRAPHY; DUODENUM ULCER; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MALE; MICROBIOLOGY; MIDDLE AGED; PROSPECTIVE STUDY; RISK FACTOR; STOMACH ULCER;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; CASE-CONTROL STUDIES; DEMOGRAPHY; DUODENAL ULCER; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; LYMPHOTOXIN-ALPHA; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RISK FACTORS; STOMACH ULCER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035751012     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363798     Document Type: Article

References (49)

1. Marshall BJ. The 1995 Albert Lasker Medical Research Award. Helicobacter pylori. The etiologic agent for peptic ulcer. JAMA 1995; 274: 1064-1066.
2. Räihä I, Kemppainen H, Kaprio J, Koskenvuo M, Sourander L. Lifestyle, stress, and genes in peptic ulcer disease. A nationwide twin cohort study. Arch Intern Med 1998; 158: 698-704.
3. Cover TL. Commentary: Helicobacter pylori transmission, host factors, and bacterial factors. Gastroenterology 1997; 113: S29-S30.
4. Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 1991; 32: 1473-1477.
5. Fan XG, Chua A, Fan XJ, Keeling PW. Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection. J Clin Pathol 1995; 48: 133-136.
6. Huseyinov A, Kutukculer N, Aydogdu S et al. Increased gastric production of platelet-activating factor, leukotriene-B4, and tumor necrosis factor-alpha in children with Helicobacter pylori infection. Dig Dis Sci 1999; 44: 675-679.
7. Noach LA, Bosma NB, Jansen J et al. Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection. Scand J Gastroenterol 1994; 29: 425-429.
8. Fiorucci S, Santucci L, Migliorati G et al. Isolated guinea pig gastric chief cells express tumour necrosis factor receptors coupled with the sphingomyelin pathway. Gut 1996; 38: 182-189.
9. Weigert N, Schaffer K, Schusdziarra V, Classen M, Schepp W. Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines. Gastroenterology 1996; 110: 147-154.
10. Shibata J, Goto H, Arisawa T et al. Regulation of tumour necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection. Gut 1999; 45: 24-31.
11. Appleyard CB, McCafferty DM, Tigley AW, Swain MG, Wallace JL. Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence. Am J Physiol 1996; 270: G42-G48.
12. Santucci L, Fiorucci S, Di Matteo FM, Morelli A. Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology 1995; 108: 393-401.
13. Molvig J, Baek L, Christensen P et al. Endotoxin-stimulated human monocyte secretion of interleukin-1, tumor necrosis factor-alpha, and prostaglandin-E2 shows stable interindividual differences. Scand J Immunol 1988; 27: 705-716.
14. Santamaria P, Gehrz RC, Bryan MK, Barbosa JJ. Involvement of class II MHC molecules in the LPS-induction of IL-1/TNF secretions by human monocytes. Quantitative differences at the polymorphic level. J Immunol 1989; 143: 913-922.
15. Jacob CO, Fronek Z, Lewis GD et al. Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci USA 1990; 87: 1233-1237.
16. Messer G, Spengler U, Jung MC et al. Polymorphic structure of the tumor necrosis factor (TNF) locus: a NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med 1991; 173: 209-219.
17. Ferencik S, Lindemann M, Horsthemke B, Grosse-Wilde H. A new restriction fragment length polymorphism of the human TNF-B gene detected by AspHI digest. Eur J Immunogenet 1992; 19: 425-430.
18. D'Alfonso S, Momigliano Richiardi P. A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics 1994; 39: 150-154.
19. Wilson AG, di Giovine FS, Blakemore AIF, Duff GW. Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Hum Mol Genet 1992; 1: 353.
20. Crusius JBA, Bing X, Mulder CJJ, Mearin ML, Peña AS. Relevance of haplotypes in the TNF region in celiac disease. (Abstract). Eur Cytok Network 1994; 2: 168.
21. Bouma G, Xia B, Crusius JBA et al. Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD). Clin Exp Immunol 1996; 103: 391-396.
22. Bouma G, Crusius JBA, Oudkerk Pool M et al. Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles: relevance for inflammatory bowel disease. Scand J Immunol 1996; 43: 456-463.
23. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor a promoter on transcription activation. Proc Natl Acad Sci USA 1997; 94: 3195-3199.
24. Moffatt MF, Cookson WO. Tumour necrosis factor haplotypes and asthma. Hum Mol Genet 1997; 6: 551-554.
25. Warzocha K, Ribeiro P, Bienvenu J et al. Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin's lymphoma outcome. Blood 1998; 91: 3574-3581.
26. Davies FE, Rollison SJ, Rawstron AC. High-producer haplotypes of tumor necrosis factor alpha and lymphotoxin alpha are associated with an increased risk of myeloma and have an improved progression-free survival after treatment. J Clin Oncol 2000; 18: 2843-2851.
27. Go MF. What are the host factors that place an individual at risk for Helicobacter pylori infection-associated disease? Gastroenterology 1997; 113: S15-S20.
28. Clarke CA, Wyn Edwards J, Haddock RW, Howel-Evans AW, McConenell RB. ABO blood groups and secretor character in duodenal ulcer. Population and sibship studies. Br Med J 1956; 3: 725-731.
29. Borén T, Falk P, Roth KA, Larson G, Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993; 262: 1892-1895.
30. Dickey W, Collins JSA, Watson RGP, Sloan JM, Porter KG. Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease. Gut 1993; 34: 351-353.
31. Niv Y, Fraser G, Delpre G et al. Helicobacter pylori infection and blood groups. Am J Gastroenterol 1996; 91: 101-104.
32. Azuma T, Ito Y, Miyaji H et al. Immunogenetic analysis of the human leukocyte antigen DQA1 locus in patients with duodenal ulcer or chronic atrophic gastritis harbouring Helicobacter pylori. Eur J Gastroenterol Hepatol 1995; 7: S71-S73.
33. Azuma T, Ito S, Sato F et al. The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection. Cancer 1998; 82: 1013-1018.
34. Beales ILP, Davey NJ, Pusey CD, Lechler RI, Calam J. Long-term sequelae of Helicobacter pylori gastritis. Lancet 1995; 346: 381-382.
35. Santolaria S, Barrios Y, Quintero E, Benito R, Lanas A. El gen HLADQA1 en la susceptibilidad a la infección por Helicobacter pylori en la úlcera péptica. Gastroenterol Hepatol 2001; 24: 117-121.
36. Weissensteiner T, Lanchbury JS. TNFB polymorphisms characterize three lineages of TNF region microsatellite haplotypes. Immunogenetics 1997; 47: 6-16.
37. Degli-Esposti MA, Leaver AL, Christiansen FT et al. Ancestral haplotypes; conserved population MHC haplotypes. Hum Immunol 1992; 34: 242-252.
38. Abraham LJ, Marley JV, Nedospasov SA et al. Microsatellite, restriction fragment-length polymorphism, and sequence-specific oligonucleotide typing of the tumor necrosis factor region. Comparisons of the 4AOHW cell panel. Hum Immunol 1993; 38: 17-23.
39. Tarnawski A, Ohta M, Wahlstrom K, Itani R, Sarfeh IJ. Expression of cytokines: IL-1alpha, IL-6 and TNFalpha in normal and ulcerated duodenal mucosa. Effect of sucralfate treatment. Gastroenterology 1997; 112: 309 (Abstract).
40. Beales ILP, Calam J. Interleukin 1-beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut 1998; 42: 227-234.
41. Pasparakis M, Alexopoulou L, Douni E, Kollias G. Tumour necrosis factors in immune regulation: everything that's interesting is...new. Cytokine Growth Factor Rev 1996; 7: 223-229.
42. Rotter JI, Petersen GM, Samloff IM. Pepsinogens and other physiologic markers in genetic studies of peptic ulcer and related disorders. Prog Clin Biol Res 1985; 173: 227-244.
43. Hein HO, Suadicani P, Gyntelberg F. Genetic markers for peptic ulcer. A study of 3387 men aged 54 to 74 years: the Copenhagen Male Study. Scand J Gastroenterol 1997; 32: 16-21.
44. Patiño-García A, Sotillo-Piñeiro E, Modesto C, Sierrasesúmaga L. Screening of the human tumor necrosis factor-alpha (TNF-α) gene promoter polymorphisms by PCR-DGGE analysis. Mutat Res 1999; 406: 121-125.
45. De la Concha EG, Fernández-Arquero M, Vigil P et al. Celiac disease and TNF promoter polymorphisms. Hum Immunol 2000; 61: 513-517.
46. Castro J, Telleria JJ, Linares P, Blanco-Quiros A. Increased TNFA*2, but not TNFB*1, allele frequencies in Spanish atopic patients. J Investig Allergol Clin Immunol 2000; 10: 149-154.
47. Lanas A, Sekar MC, Hirschowitz BI. Objective evidence of aspirin use in both ulcer and nonulcer upper and lower gastrointestinal bleeding. Gastroenterology 1992; 103: 862-869.
48. Peña AS, Crusius JBA, Koutroubakis I et al. Preliminary results on cytokine genes and mucin genes polymorphisms. In: Inflammatory Bowel Diseases. Netherlands Falk Symposium No. 85, Kluwer Academic Publishers: Den Haag, 1995, pp 232-238.
49. Fanning GC, Bunce M, Black CM, Welsh KI. Polymerase chain reaction haplotyping using 3′ mismatches in the forward and reverse primers: application to the biallelic polymorphisms of tumor necrosis factor and lymphotoxin alpha. Tissue Antigens 1997; 50: 23-31.