Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability

International Journal of Pharmaceutics

Volumn 477, Issue 1-2, 2014, Pages 96-101

  Song, Jung Min ^a   Kirtane, Ameya R ^b   Upadhyaya, Pramod ^a   Qian, Xuemin ^a   Balbo, Silvia ^a   Teferi, Fitsum ^a   Panyam, Jayanth ^a,b   Kassie, Fekadu ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

4 (Methylnitro samino) 1 (3 pyridyl) 1 butanone; Cytochrome P450 1A1; DNA adduct; Indole 3 carbinol; Liposomes; O6 Methylguanine DNA adduct

Indexed keywords

3 INDOLEMETHANOL; 4 (METHYLNITRO SAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; LIPOSOME; TOBACCO SMOKE; UNCLASSIFIED DRUG; 4-(N-METHYL-N-NITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; INDOLE-3-CARBINOL; NITROSAMINE;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DETOXIFICATION; DNA ADDUCT; DRUG BIOAVAILABILITY; DRUG FORMULATION; FEMALE; LIPOSOMAL DELIVERY; LUNG CANCER; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BIOAVAILABILITY; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRANASAL DRUG ADMINISTRATION; LUNG; LUNG NEOPLASMS; METABOLISM; ORAL DRUG ADMINISTRATION; TISSUE DISTRIBUTION;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; BIOLOGICAL AVAILABILITY; CARCINOGENS; CYTOCHROME P-450 CYP1A1; DRUG DELIVERY SYSTEMS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INDOLES; LIPOSOMES; LUNG; LUNG NEOPLASMS; MICE; NITROSAMINES; TISSUE DISTRIBUTION;

EID: 84908410375     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.10.018     Document Type: Article

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