Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: Inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats

Food and Chemical Toxicology

Volumn 38, Issue 1, 2000, Pages 15-23

  Friesen, M D ^b   Ruch, R J ^a   Schut, H A J ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Chemoprevention; DNA adducts; Food mutagens; Heterocyclic amines; Indole 3 carbinol; PhIP

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 3 INDOLEMETHANOL; CYTOCHROME P450; HETEROCYCLIC AMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST EPITHELIUM; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; ENZYME ACTIVITY; ENZYME METABOLISM; EPITHELIUM CELL; GROWTH INHIBITION; LABELING INDEX; METABOLIC ACTIVATION; NONHUMAN; RAT; TUMOR GROWTH;

ANIMALS; ANTICARCINOGENIC AGENTS; CELL TRANSFORMATION, NEOPLASTIC; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INDUCTION; FEMALE; FOOD CONTAMINATION; IMIDAZOLES; INDOLES; MUTAGENS; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0033964256     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00117-9     Document Type: Article

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