Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 307, Issue 9, 2014, Pages E813-E821

  Drake, Joshua C ^a   Bruns, Danielle R ^a   Peelor, Frederick F ^a   Biela, Laurie M ^a   Miller, Richard A ^b   Hamilton, Karyn L ^a   Miller, Benjamin F ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Crowded litter; Deuterium; mTORC1; Proteostasis; Slowed aging

Indexed keywords

DNA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

AGING; ANIMAL EXPERIMENT; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CROWDED LITTER; DNA SYNTHESIS; LITTER SIZE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA TRANSLATION; SIGNAL TRANSDUCTION; ALGORITHM; ANIMAL; BIOSYNTHESIS; CARDIAC MUSCLE; CROSS BREEDING; DOWN REGULATION; FEMALE; GROWTH, DEVELOPMENT AND AGING; HEART; HINDLIMB; LIVER; LONGEVITY; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING; SKELETAL MUSCLE; SUCKLING ANIMAL; UPREGULATION;

AGING; ALGORITHMS; ANIMALS; ANIMALS, SUCKLING; CROSSES, GENETIC; DNA; DOWN-REGULATION; FEMALE; HEART; HINDLIMB; LITTER SIZE; LIVER; LONGEVITY; MICE; MULTIPROTEIN COMPLEXES; MUSCLE, SKELETAL; MYOCARDIUM; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84908387316     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00256.2014     Document Type: Article

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