Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation

Brain

Volumn 137, Issue 10, 2014, Pages 2703-2714

  Beltrán, Eduardo ^a,b   Obermeier, Birgit ^a   Moser, Markus ^c   Coret, Francisco ^d   Simó Castelló, María ^b   Boscá, Isabel ^b   Pérez Miralles, Francisco ^b   Villar, Luisa M ^e   Senel, Makbule ^f   Tumani, Hayrettin ^f   Hohlfeld, Reinhard ^a,g   Casanova, Bonaventura ^b   Dornmair, Klaus ^a,g  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF VALENCIA   (Spain)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^e HOSPITAL RAMÓN Y CAJAL   (Spain)

^f UNIVERSITY OF ULM   (Germany)

^g UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cerebrospinal fluid; Immunoglobulin; Multiple sclerosis; Neuroborreliosis; Oligoclonal bands

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; NATALIZUMAB; OLIGOCLONAL BAND;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CEREBROSPINAL FLUID; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MULTIPLE SCLEROSIS; NEUROBORRELIOSIS; NUCLEOTIDE SEQUENCE; SINGLE CELL ANALYSIS; SOMATIC HYPERMUTATION; SPINAL CORD; VERY ELDERLY; YOUNG ADULT;

CEREBROSPINAL FLUID; IMMUNOGLOBULIN; MULTIPLE SCLEROSIS; NEUROBORRELIOSIS; OLIGOCLONAL BANDS;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL, HUMANIZED; B-LYMPHOCYTES; BASE SEQUENCE; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLAMMATION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; SINGLE-CELL ANALYSIS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SPINAL CORD; YOUNG ADULT;

EID: 84908377209     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awu205     Document Type: Article

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