High-affinity GABA uptake by neuronal GAT1 transporters provokes release of [3H]GABA by homoexchange and through GAT1-independent Ca2+-mediated mechanisms

Neuropharmacology

Volumn 88, Issue , 2015, Pages 164-170

  Romei, Cristina ^a   Sabolla, Chiara ^a   Raiteri, Luca ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b National Institute of Neuroscience   (Italy)

Author keywords

Anion channels; GABA GAT1 transporter; GABA homoexchange; GABA release; Mitochondrial Na+ Ca2+ exchanger; Plasmalemmal Na+ Ca2+ exchanger

Indexed keywords

1 (4,4 DIPHENYL 3 BUTENYL)NIPECOTIC ACID; 2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID H 3; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; 7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; ANION CHANNEL; GABA TRANSPORTER 1; IFENPRODIL; NIFLUMIC ACID; RADIOPHARMACEUTICAL AGENT; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID CARRIER; CALCIUM; CATION; ION CHANNEL; SLC6A1 PROTEIN, MOUSE; SODIUM; TRITIUM;

4 AMINOBUTYRIC ACID RELEASE; 4 AMINOBUTYRIC ACID UPTAKE; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM SIGNALING; CONTROLLED STUDY; MALE; MOUSE; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; SODIUM CALCIUM EXCHANGE; ANIMAL; CEREBELLUM; DRUG EFFECTS; METABOLISM; MITOCHONDRION; NERVE CELL; SYNAPTOSOME;

ANIMALS; CALCIUM; CATIONS; CEREBELLUM; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; ION CHANNELS; MALE; MICE; MITOCHONDRIA; NEURONS; SODIUM; SODIUM-CALCIUM EXCHANGER; SYNAPTOSOMES; TRITIUM;

EID: 84908372903     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.08.007     Document Type: Article

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