Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake

Journal of Pharmacology and Experimental Therapeutics

Volumn 326, Issue 2, 2008, Pages 646-656

  Colleoni, Simona ^a   Jensen, Anders A ^b   Landucci, Elisa ^c   Fumagalli, Elena ^a   Conti, Paola ^d   Pinto, Andrea ^d   De Amici, Marco ^d   Pellegrini Giampietro, Domenico E ^c   De Micheli, Carlo ^d   Mennini, Tiziana ^a   Gobbi, Marco ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4,5,6,6A TETRAHYDRO 3AH PYRROLO[3,4 D]ISOXAZOLE 4 CARBOXYLIC ACID; 3 HYDROXY 4,5,6,6A TETRAHYDRO 3AH PYRROLO[3,4 D]ISOXAZOLE 6 CARBOXYLIC ACID; ASPARTIC ACID; ASPARTIC ACID DERIVATIVE; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE TRANSPORTER; GLUTAMATE TRANSPORTER INHIBITOR; GLUTAMIC ACID; PROTEIN INHIBITOR; THREO BETA BENZYLOXYASPARTIC ACID; TRITIUM;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN SLICE; BRAIN SYNAPTOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENANTIOMER; HIPPOCAMPUS; HUMAN; HUMAN CELL; IC 50; ISOMER; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TISSUE CULTURE;

ANIMALS; BIOLOGICAL TRANSPORT; CARBOXYLIC ACIDS; CELL LINE; CELL SURVIVAL; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID TRANSPORTER 1; GLUTAMIC ACID; HUMANS; MALE; MEMBRANE POTENTIALS; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; OXAZOLES; RATS; RATS, INBRED STRAINS; STEREOISOMERISM; SYNAPTOSOMES;

EID: 47849133459     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.135251     Document Type: Article

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