Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 28, 2013, Pages 11642-11647

  Buchmayer, Florian ^a   Schicker, Klaus ^a   Steinkellner, Thomas ^a   Geier, Petra ^a   Stübiger, Gerald ^a   Hamilton, Peter J ^b   Jurik, Andreas ^c   Stockner, Thomas ^a   Yang, Jae Won ^a   Montgomery, Therese ^a,d   Holy, Marion ^a   Hofmaier, Tina ^a   Kudlacek, Oliver ^a   Matthies, Heinrich J G ^b   Ecker, Gerhard F ^c   Bochkov, Valery ^a   Galli, Aurelio ^b   Boehm, Stefan ^a   Sitte, Harald H ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Amperometry; Mass spectrometry; Phosphoinositide; Release; Reuptake

Indexed keywords

AMPHETAMINE; NEUROTRANSMITTER; NORADRENALIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; SEROTONIN TRANSPORTER;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN SLICE; CONTROLLED STUDY; ENZYME ACTIVATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

AMPEROMETRY; MASS SPECTROMETRY; PHOSPHOINOSITIDE; RELEASE; REUPTAKE;

AMPHETAMINE; HEK293 CELLS; HUMANS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; SECOND MESSENGER SYSTEMS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

RATTUS;

EID: 84879927466     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220552110     Document Type: Article

References (37)

1. Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443(7112):651-657. (Pubitemid 44564702)
2. Tolias KF, Cantley LC (1999) Pathways for phosphoinositide synthesis. Chem Phys Lipids 98(1-2):69-77. (Pubitemid 29150396)
3. Marín-Vicente C, Nicolás FE, Gómez-Fernández JC, Corbalán-García S (2008) The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells. J Mol Biol 377(4):1038-1052.
4. Pike LJ, Miller JM (1998) Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J Biol Chem 273(35):22298-22304. (Pubitemid 28399788)
5. Di Paolo G, et al. (2004) Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature 431(7007):415-422. (Pubitemid 39329574)
6. Haucke V (2005) Phosphoinositide regulation of clathrin-mediated endocytosis. Biochem Soc Trans 33(Pt 6):1285-1289.
7. Hilgemann DW, Ball R (1996) Regulation of cardiac Na+, Ca2+-exchange and KATP potassium channels by PIP2. Science 273(80):956-959. (Pubitemid 26275172)
8. Gamper N, Shapiro MS (2007) Regulation of ion transport proteins by membrane phosphoinositides. Nat Rev Neurosci 8(12):921-934. (Pubitemid 350146933)
9. Kristensen AS, et al. (2011) SLC6 neurotransmitter transporters: Structure, function, and regulation. Pharmacol Rev 63(3):585-640.
10. Sitte HH, Freissmuth M (2010) The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters-why amphetamines take two to tango. J Neurochem 112(2):340-355.
11. Guicheney P, et al. (1988) Platelet 5-HT content and uptake in essential hypertension: Role of endogenous digitalis-like factors and plasma cholesterol. J Hypertens 6(11):873-879. (Pubitemid 19038165)
12. Scanlon SM, Williams DC, Schloss P (2001) Membrane cholesterol modulates serotonin transporter activity. Biochemistry 40(35):10507-10513. (Pubitemid 32816661)
13. Magnani F, Tate CG, Wynne S, Williams C, Haase J (2004) Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin. J Biol Chem 279(37):38770-38778. (Pubitemid 39296035)
14. Hong WC, Amara SG (2010) Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding. J Biol Chem 285(42):32616-32626.
15. Hilber B, et al. (2005) Serotonin-transporter mediated efflux: A pharmacological analysis of amphetamines and non-amphetamines. Neuropharmacology 49(6):811-819. (Pubitemid 41483887)
16. Hilgemann DW, Feng S, Nasuhoglu C (2001) The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE 2001(111):re19.
17. Schicker K, et al. (2012) Unifying concept of serotonin transporter-associated currents. J Biol Chem 287(1):438-445.
18. Robbins J, Marsh SJ, Brown DA (2006) Probing the regulation of M (Kv7) potassium channels in intact neurons with membrane-targeted peptides. J Neurosci 26(30):7950-7961. (Pubitemid 44315164)
19. Bae Y-S, et al. (2003) Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol 63(5):1043-1050. (Pubitemid 36529922)
20. Mager S, et al. (1994) Conducting states of a mammalian serotonin transporter. Neuron 12(4):845-859. (Pubitemid 24126245)
21. Gutowski S, et al. (1991) Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones. J Biol Chem 266(30):20519-20524. (Pubitemid 21908491)
22. Quick MW (2003) Regulating the conducting states of a mammalian serotonin transporter. Neuron 40(3):537-549.
23. Sitte HH, et al. (1998) Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter. J Neurochem 71(3):1289-1297. (Pubitemid 28390284)
24. Khoshbouei H, Wang H, Lechleiter JD, Javitch JA, Galli A (2003) Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. J Biol Chem 278(14):12070-12077. (Pubitemid 36800184)
25. Seidel S, et al. (2005) Amphetamines take two to tango: An oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action. Mol Pharmacol 67(1):140-151. (Pubitemid 40069974)
26. Sitte HH, et al. (2001) Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: Inconsistencies with the hypothesis of facilitated exchange diffusion. Mol Pharmacol 59(5):1129-1137. (Pubitemid 32381593)
27. Várnai P, Balla T (1998) Visualization of phosphoinositides that bind pleckstrin homology domains: Calcium- and agonist-induced dynamic changes and relationship to myo-[3H] inositol-labeled phosphoinositide pools. J Cell Biol 143(2):501-510. (Pubitemid 28487866)
28. Johnson LA, Guptaroy B, Lund D, Shamban S, Gnegy ME (2005) Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. J Biol Chem 280(12):10914-10919. (Pubitemid 40418392)
29. Gnegy ME, et al. (2004) Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Mol Pharmacol 66(1):137-143. (Pubitemid 38822096)
30. Schmitt KC, Reith MEA (2010) Regulation of the dopamine transporter: Aspects relevant to psychostimulant drugs of abuse. Ann N Y Acad Sci 1187:316-340.
31. Nelson N (1998) The family of Na+/Cl- neurotransmitter transporters. J Neurochem 71(5):1785-1803.
32. Beuming T, Shi L, Javitch JA, Weinstein H (2006) A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol 70(5):1630-1642.
33. Rosenhouse-Dantsker A, Logothetis DE (2007) Molecular characteristics of phosphoinositide binding. Pflügers Archiv 455(1):45-53. (Pubitemid 47403985)
34. Haider S, Tarasov AI, Craig TJ, Sansom MSP, Ashcroft FM (2007) Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis. EMBO J 26(16):3749-3759. (Pubitemid 47295876)
35. Robertson SD, Matthies HJG, Galli A (2009) A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters. Mol Neurobiol 39(2):73-80.
36. Carvelli L, et al. (2004) Dopamine transporters depolarize neurons by a channel mechanism. Proc Natl Acad Sci USA 101(45):16046-16051. (Pubitemid 39507924)
37. Mazei-Robison MS, et al. (2008) Anomalous dopamine release associated with a human dopamine transporter coding variant. J Neurosci 28(28):7040-7046.