2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 22, 2014, Pages 6459-6470

  Sayer, James R ^a,d   Walldén, Karin ^b,e   Pesnot, Thomas ^a,f   Campbell, Frederick ^a,g   Gane, Paul J ^c,h   Simone, Michela ^c   Koss, Hans ^a   Buelens, Floris ^b,i   Boyle, Timothy P ^a,j   Selwood, David L ^c   Waksman, Gabriel ^b   Tabor, Alethea B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MEDPHARM LTD   (United Kingdom)

^e KAROLINSKA INSTITUTE   (Sweden)

^f ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^g LEIDEN UNIVERSITY   (Netherlands)

^h WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

ⁱ MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^j UNIVERSITY OF NEW SOUTH WALES   (Australia)

more..

Author keywords

8 Amino imidazo 1,2 a pyrazine; ATPase inhibitor; Bacterial type IV secretion system; HP0525

Indexed keywords

2 AMINO 1 (2 NAPHTHYL)ETHANOL; 2 AZIDO 1 (2 NAPHTHYL)ETHANONE; 2 AZIDO 1 (2-NAPHTHYL)ETHANOL; 2 BROMO 1 (2 PHENOXYPHENYL)ETHANONE; 2 [(3 CHLOROPYRAZIN 2 YL)AMINO] 1 (2 NAPHTHYL)ETHANOL; 2 [(3 CHLOROPYRAZIN 2 YL)AMINO] 1 (2 NAPHTHYL)ETHANONE; 4 METHYL N [2 (2 NAPHTHYL)IMIDAZO[1,2 A]PYRAZINE 8 YL]BENZENESULFONAMIDE; 4 METHYL N [4 [2 (2 NAPHTHYL)IMIDAZO[1,2 A]PYRAZINE 8 YL]AMINOPHENYL]BENZENESULFONAMIDE; 4 METHYL N [4 [3 (2 NAPHTHYL)IMIDAZO[1,2 A]PYRAZINE 8 YL]AMINOPHENYL]BENZENESULFONAMIDE; 8 (METHYLSULFONYL) 2 (NAPHTHALEN 2 YL)IMIDAZO[1,2 A]PYRAZINE; 8 AMINO IMIDAZO[1,2 A]PYRAZINE DERIVATIVE; 8 CHLORO 2 (2 NAPHTHYL)IMIDAZO[1,2 A]PYRAZINE; 8 CHLORO 3 (2 NAPHTHYL)IMIDAZO[1,2 A]PYRAZINE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; HP 0525; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; IMIDAZO(1,2-A)PYRAZINE; IMIDAZOLE DERIVATIVE; PROTEIN BINDING;

ARTICLE; BACTERIAL SECRETION SYSTEM; BACTERIAL TYPE IV SECRETION; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HELICOBACTER PYLORI; IC50; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; NONHUMAN; PHYSICAL CHEMISTRY; STEADY STATE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; GRAM NEGATIVE BACTERIUM; KINETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; GRAM-NEGATIVE BACTERIA; IMIDAZOLES; KINETICS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908360366     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.09.036     Document Type: Article

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