Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5170-5174

  Belanger, David B ^a   Curran, Patrick J ^a   Hruza, Alan ^a   Voigt, Johannes ^a   Meng, Zhaoyang ^a   Mandal, Amit K ^a   Siddiqui, M Arshad ^a   Basso, Andrea D ^a   Gray, Kimberly ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aurora kinase inhibitors; Imidazo 1,2 a pyrazine

Indexed keywords

AURORA KINASE INHIBITOR; IMIDAZOPYRAZINE DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BLOOD PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; FLOW CYTOMETRY; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955655331     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.008     Document Type: Article

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