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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 10, 2012, Pages 3544-3549

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity

(10) Voss, Matthew E a Rainka, Matthew P a Fleming, Mike a Peterson, Lisa H a Belanger, David B b Siddiqui, M Arshad b Hruza, Alan b Voigt, Johannes b Gray, Kimberly b Basso, Andrea D b

a ALBANY MOLECULAR RESEARCH INC (United States)

b MERCK RESEARCH LABORATORIES (United States)

Author keywords

Aurora kinase inhibitors; Imidazo 1,2 a pyrazine; Selective kinase inhibitor

Indexed keywords

ACETIC ACID; AURORA A KINASE; AURORA B KINASE; AURORA KINASE INHIBITOR; IMIDAZO[1,2 A]PYRAZINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CRYSTALLOGRAPHY, X-RAY; IMIDAZOLES; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860436486 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.03.051 Document Type: Article

Times cited : (12)

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