The SH2 Domain Regulates c-Abl Kinase Activation by a Cyclin-Like Mechanism and Remodulation of the Hinge Motion

PLoS Computational Biology

Volumn 10, Issue 10, 2014, Pages

  Dölker, Nicole ^a   Górna, Maria W ^b   Sutto, Ludovico ^c   Torralba, Antonio S ^a   Superti Furga, Giulio ^b   Gervasio, Francesco L ^c  

^a Structural Biology and Biocomputing Programme   (Spain)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMPLEX NETWORKS; ENZYMES;

ACTIVATION LOOPS; CATALYTIC DOMAINS; CELLULAR SIGNALLING; COMPUTATIONAL SIMULATION; CYCLINS; KINASE ACTIVATION; LOCAL EFFECTS; REMODULATION; SRC HOMOLOGY 2 DOMAINS; TYROSINE KINASE;

CHEMICAL ACTIVATION;

ABELSON KINASE; CYCLIN DEPENDENT KINASE; PROTEIN SH2; CYCLINE;

ALLOSTERIC COUPLING; ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPUTER MODEL; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HEK293 CELL LINE; HINGE MOTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MUTAGENESIS; POINT MUTATION; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SRC HOMOLOGY DOMAIN; THERMODYNAMICS;

COMPUTER SIMULATION; CYCLINS; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-ABL; SRC HOMOLOGY DOMAINS; THERMODYNAMICS;

EID: 84908348822     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003863     Document Type: Article

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