The different flexibility of c-Src and c-Abl kinases regulates the accessibility of a druggable inactive conformation

Journal of the American Chemical Society

Volumn 134, Issue 5, 2012, Pages 2496-2499

  Lovera, Silvia ^a   Sutto, Ludovico ^a   Boubeva, Ralitza ^b   Scapozza, Leonardo ^b   Dölker, Nicole ^a   Gervasio, Francesco L ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER DRUG; ANTICANCER TARGETS; CONFORMATIONAL CHANGE; CONFORMATIONAL TRANSITIONS; FREE ENERGY SURFACE; FREE-ENERGY CALCULATIONS; IMATINIB; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN KINASE; SEQUENCE IDENTITY;

FREE ENERGY; MOLECULAR DYNAMICS;

ENZYMES;

ABELSON KINASE; IMATINIB; PROTEIN KINASE;

ARTICLE; DRUG TARGETING; ENERGY; ENZYME CONFORMATION; ENZYME STRUCTURE; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; ONCOGENE SRC; PROTEIN MOTIF;

CALORIMETRY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-ABL; SRC-FAMILY KINASES;

EID: 84856694630     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja210751t     Document Type: Article

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