Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation

Biochemical Pharmacology

Volumn 92, Issue 2, 2014, Pages 251-265

  Kim, Sung Dae ^a   Lee, Young Ji ^a   Baik, Ji Sue ^a   Han, Joeng Yoon ^a   Lee, Chang Geun ^a   Heo, Kyu ^a   Park, You Soo ^a   Kim, Joong Sun ^a   Ji, Hyun Dong ^b   Park, Se Il ^c   Rhee, Man Hee ^b   Yang, Kwangmo ^a,d  

^a Dongnam Institute of Radiological and Medical Science   (South Korea)

^b Kyungpook National University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

^d Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Baicalein; Metastasis; PI 3K; Platelets; TCIPA

Indexed keywords

ADENOSINE TRIPHOSPHATE; BAICALEIN; CALCIUM ION; COLLAGEN; CYCLIC AMP; CYCLIC GMP; FIBRINOGEN; FORSKOLIN; INTEGRIN; ISOBUTYLMETHYLXANTHINE; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; THROMBIN; VASODILATOR STIMULATED PHOSPHOPROTEIN; ACTIN BINDING PROTEIN; CELL ADHESION MOLECULE; ENZYME INHIBITOR; FLAVANONE DERIVATIVE; PHOSPHOPROTEIN; VASODILATOR-STIMULATED PHOSPHOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL ADHESION; CELL GRANULE; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLIOMA CELL; IC50; IN VITRO STUDY; LIGAND BINDING; LUNG METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SINGLE DRUG DOSE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; TUMOR CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; THROMBOCYTE AGGREGATION; TUMOR CELL LINE;

ANIMALS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CYCLIC AMP; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVANONES; MALE; MICE; MICE, INBRED BALB C; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET AGGREGATION; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84908345385     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.09.019     Document Type: Article

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