Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization

British Journal of Pharmacology

Volumn 152, Issue 1, 2007, Pages 73-82

  Chang, M C ^a   Uang, B J ^b   Tsai, C Y ^c   Wu, H L ^b   Lin, B R ^d   Lee, C S ^a   Chen, Y J ^d   Chang, C H ^a   Tsai, Y L ^d   Kao, C J ^a   Jeng, J H ^d  

^a CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Betel leaf; Calcium; Cyclooxygenase; Hydroxychavicol; Platelet aggregation; Thromboxane

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; BETEL EXTRACT; CALCIUM; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EUGENOL; HYDROXYCHAVICOL; LACTATE DEHYDROGENASE; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BETEL NUT; BLEEDING TIME; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REPRESSION; FLUORESCENCE; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOSIS;

ANIMALS; ARACHIDONIC ACID; BLEEDING TIME; BLOOD PLATELETS; CALCIUM SIGNALING; COLLAGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EUGENOL; MALE; MICE; MICE, INBRED ICR; PIPER BETLE; PLANT LEAVES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; THROMBIN; THROMBOXANE B2;

EID: 34548336803     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707367     Document Type: Article

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