메뉴 건너뛰기




Volumn 36, Issue 1, 2012, Pages 40-46

Total saponin from Korean red ginseng inhibits thromboxane A2 production associated microsomal enzyme activity in platelets

Author keywords

Cyclooxygenase 1; Total saponin from korean red ginseng

Indexed keywords

PANAX GINSENG;

EID: 84862944450     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2012.36.1.40     Document Type: Article
Times cited : (34)

References (38)
  • 1
    • 0025173097 scopus 로고
    • Developmental mechanisms underlying pathology of arteries
    • Schwartz SM, Heimark RL, Majesky MW. Developmental mechanisms underlying pathology of arteries. Physiol Rev 1990;70:1177-1209.
    • (1990) Physiol Rev , vol.70 , pp. 1177-1209
    • Schwartz, S.M.1    Heimark, R.L.2    Majesky, M.W.3
  • 2
    • 27644525019 scopus 로고
    • Inositol trisphosphate, a novel second messenger in cellular signal transduction
    • Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984;12:15-21.
    • (1984) Nature , vol.12 , pp. 15-21
    • Berridge, M.J.1    Irvine, R.F.2
  • 3
    • 58649085872 scopus 로고    scopus 로고
    • Role of platelets in atherothrombosis
    • Jennings LK. Role of platelets in atherothrombosis. Am J Cardiol 2009;10(Suppl):4A-10A.
    • (2009) Am J Cardiol , vol.10 , Issue.SUPPL.
    • Jennings, L.K.1
  • 4
    • 0026098321 scopus 로고
    • Nitroprusside in vitro inhibits platelet aggregation and intracellular calcium translocation. Effect of haemoglobin
    • Pasqui AL, Capecchi PL, Ceccatelli L, Mazza S, Gistri A, Laghi Pasini F, Di Perri T. Nitroprusside in vitro inhibits platelet aggregation and intracellular calcium translocation. Effect of haemoglobin. Thromb Res 1991;61:11-122.
    • (1991) Thromb Res , vol.61 , pp. 11-122
    • Pasqui, A.L.1    Capecchi, P.L.2    Ceccatelli, L.3    Mazza, S.4    Gistri, A.5    Laghi, P.F.6    Di Perri, T.7
  • 5
    • 0019226552 scopus 로고
    • Ca2+-calmodulindependent phosphorylation and platelet secretion
    • Nishikawa M, Tanaka T, Hidaka H. Ca2+-calmodulindependent phosphorylation and platelet secretion. Nature 1980;287:86-865.
    • (1980) Nature , vol.287 , pp. 86-865
    • Nishikawa, M.1    Tanaka, T.2    Hidaka, H.3
  • 6
    • 0023037081 scopus 로고
    • Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids
    • Murakami K, Chan SY, Routtenberg A. Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids. J Biol Chem 1986;261:15424-15429.
    • (1986) J Biol Chem , vol.261 , pp. 15424-15429
    • Murakami, K.1    Chan, S.Y.2    Routtenberg, A.3
  • 7
    • 0016748441 scopus 로고
    • Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
    • Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci U S A 1975;72:2994-2998.
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 2994-2998
    • Hamberg, M.1    Svensson, J.2    Samuelsson, B.3
  • 8
    • 0025763412 scopus 로고
    • In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production
    • Cattaneo M, Tenconi PM, Lecchi A, Mannucci PM. In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production. Thromb Res 1991;62:717-724.
    • (1991) Thromb Res , vol.62 , pp. 717-724
    • Cattaneo, M.1    Tenconi, P.M.2    Lecchi, A.3    Mannucci, P.M.4
  • 9
    • 0023900121 scopus 로고
    • Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen
    • Moriyama T, Takamura H, Narita H, Tanaka K, Matsuura T, Kito M. Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. J Biochem 1988;10:901-902.
    • (1988) J Biochem , vol.10 , pp. 901-902
    • Moriyama, T.1    Takamura, H.2    Narita, H.3    Tanaka, K.4    Matsuura, T.5    Kito, M.6
  • 10
    • 0028354308 scopus 로고
    • Aspirin as an antiplatelet drug
    • Patrono C. Aspirin as an antiplatelet drug. N Engl J Med 1994;0:1287-1294.
    • (1994) N Engl J Med , vol.0 , pp. 1287-1294
    • Patrono, C.1
  • 12
    • 0035825137 scopus 로고    scopus 로고
    • Aspirin: New cardiovascular uses for an old drug
    • Patrono C. Aspirin: new cardiovascular uses for an old drug. Am J Med 2001;110:62S-65S.
    • (2001) Am J Med , vol.110
    • Patrono, C.1
  • 13
    • 0032850490 scopus 로고    scopus 로고
    • Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models
    • Ichikawa K, Tazawa S, Hamano S, Kojima M, Hiraku S. Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models. Pharmacology 1999;59:257-265.
    • (1999) Pharmacology , vol.59 , pp. 257-265
    • Ichikawa, K.1    Tazawa, S.2    Hamano, S.3    Kojima, M.4    Hiraku, S.5
  • 14
    • 0029806065 scopus 로고    scopus 로고
    • Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation
    • Park HJ, Lee JH, Song YB, Park KH. Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation. Biol Pharm Bull 1996;19:144-149.
    • (1996) Biol Pharm Bull , vol.19 , pp. 144-149
    • Park, H.J.1    Lee, J.H.2    Song, Y.B.3    Park, K.H.4
  • 15
    • 0029619278 scopus 로고
    • Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation
    • Park HJ, Rhee MH, Park KM, Nam KY, Park KH. Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation. J Ethnopharmacol 1995;49:157-162.
    • (1995) J Ethnopharmacol , vol.49 , pp. 157-162
    • Park, H.J.1    Rhee, M.H.2    Park, K.M.3    Nam, K.Y.4    Park, K.H.5
  • 16
    • 84862912705 scopus 로고    scopus 로고
    • Inhibition of serotonin release by lipophilic fraction from Korean red ginseng
    • 127-10
    • Rhee MH, Park KM, Park HJ, Nam KY, Park KH. Inhibition of serotonin release by lipophilic fraction from Korean red ginseng. Korean J Ginseng Sci 199;17:127-10.
    • Korean J Ginseng Sci , vol.199 , Issue.17
    • Rhee, M.H.1    Park, K.M.2    Park, H.J.3    Nam, K.Y.4    Park, K.H.5
  • 17
    • 84862913971 scopus 로고
    • Effects of protein fractions and ginsenosides from Panax ginseng C.A. Meyer on substrate phosphorylation by a catalytic fragment of protein kinase
    • 280-28
    • Park HJ, No YH, Rhee MH, Park KM, Park KH. Effects of protein fractions and ginsenosides from Panax ginseng C.A. Meyer on substrate phosphorylation by a catalytic fragment of protein kinase. Korean Biochem J 1994;27:280-28.
    • (1994) Korean Biochem J , vol.27
    • Park, H.J.1    No, Y.H.2    Rhee, M.H.3    Park, K.M.4    Park, K.H.5
  • 21
    • 84862972977 scopus 로고
    • Panaxadiol and panaxatriol from Panax ginseng C.A. Meyer inhibit the synthesis of thromboxane A2 in adrenaline-stimulated human platelet aggregation
    • Park KM, Rhee MH, Park HJ. Panaxadiol and panaxatriol from Panax ginseng C.A. Meyer inhibit the synthesis of thromboxane A2 in adrenaline-stimulated human platelet aggregation. Korean J Ginseng Sci 1994;18:44-48.
    • (1994) Korean J Ginseng Sci , vol.18 , pp. 44-48
    • Park, K.M.1    Rhee, M.H.2    Park, H.J.3
  • 22
    • 84862922333 scopus 로고    scopus 로고
    • Panaxadiol from Panax ginseng C.A. Meyer inhibits synthesis of thromboxane A2 in platelet aggregation induced by thrombin
    • Park HJ, Rhee MH, Park KM, Nam KY, Park KH. Panaxadiol from Panax ginseng C.A. Meyer inhibits synthesis of thromboxane A2 in platelet aggregation induced by thrombin. Korean J Ginseng Sci 199;17:11-14.
    • Korean J Ginseng Sci , vol.199 , Issue.17 , pp. 11-14
    • Park, H.J.1    Rhee, M.H.2    Park, K.M.3    Nam, K.Y.4    Park, K.H.5
  • 23
    • 0024259744 scopus 로고
    • Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets
    • 88-84
    • Kimura Y, Okuda H, Arichi S. Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 1988;40:88-84.
    • (1988) J Pharm Pharmacol , vol.40
    • Kimura, Y.1    Okuda, H.2    Arichi, S.3
  • 24
    • 84862913213 scopus 로고    scopus 로고
    • Inhibitory mechanisms of dihydroginsenoside Rg in platelet aggregation: Critical roles of ERK2 and cAMP
    • Lee WM, Kim SD, Park MH, Cho JY, Park HJ, Seo GS, Rhee MH. Inhibitory mechanisms of dihydroginsenoside Rg in platelet aggregation: critical roles of ERK2 and cAMP. J Pharm Pharmacol 2008;60:151-156.
    • (2008) J Pharm Pharmacol , vol.60 , pp. 151-156
    • Lee, W.M.1    Kim, S.D.2    Park, M.H.3    Cho, J.Y.4    Park, H.J.5    Seo, G.S.6    Rhee, M.H.7
  • 25
    • 0014207264 scopus 로고
    • Studies of the aggregation of human blood platelets. On the inhibition of platelet aggregation in EDTA plasma following incubation at 7 degrees C
    • Reuter H, Niemeyer G, Gross R. Studies of the aggregation of human blood platelets. On the inhibition of platelet aggregation in EDTA plasma following incubation at 7 degrees C. Klin Wochenschr 1967;45:1147-1149.
    • (1967) Klin Wochenschr , vol.45 , pp. 1147-1149
    • Reuter, H.1    Niemeyer, G.2    Gross, R.3
  • 26
    • 0019395445 scopus 로고
    • Localisation of phospholipase A2 and diglyceride lipase activities in human platelet intracellular membranes
    • Lagarde M, Menashi S, Crawford N. Localisation of phospholipase A2 and diglyceride lipase activities in human platelet intracellular membranes. FEBS Lett 1981;124:2-26.
    • (1981) FEBS Lett , vol.124 , pp. 2-26
    • Lagarde, M.1    Menashi, S.2    Crawford, N.3
  • 27
    • 0036851876 scopus 로고    scopus 로고
    • Platelets in atherothrombosis
    • 1227-124
    • Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002;8:1227-124.
    • (2002) Nat Med , vol.8
    • Ruggeri, Z.M.1
  • 28
    • 0026052859 scopus 로고
    • Mechanisms of platelet activation: Thromboxane A2 as an amplifying signal for other agonists
    • FitzGerald GA. Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists. Am J Cardiol 1991;68:11B-15B.
    • (1991) Am J Cardiol , vol.68
    • Fitzgerald, G.A.1
  • 29
    • 0034779677 scopus 로고    scopus 로고
    • Pharmacological control of platelet function
    • Clutton P, Folts JD, Freedman JE. Pharmacological control of platelet function. Pharmacol Res 2001;44:255-264.
    • (2001) Pharmacol Res , vol.44 , pp. 255-264
    • Clutton, P.1    Folts, J.D.2    Freedman, J.E.3
  • 32
    • 0008061442 scopus 로고
    • Biosynthesis and metabolism of prostaglandins
    • Samuelsson B. Biosynthesis and metabolism of prostaglandins. Prog Biochem Pharmacol 1967;:59-70.
    • (1967) Prog Biochem Pharmacol , pp. 59-70
    • Samuelsson, B.1
  • 33
    • 0017611405 scopus 로고
    • Metabolism of prostaglandin endoperoxide in animal tissues
    • Sun FF, Chapman JP, McGuire JC. Metabolism of prostaglandin endoperoxide in animal tissues. Prostaglandins 1977;14:1055-1074.
    • (1977) Prostaglandins , vol.14 , pp. 1055-1074
    • Sun, F.F.1    Chapman, J.P.2    McGuire, J.C.3
  • 35
    • 0004752240 scopus 로고    scopus 로고
    • Inhibitory effects of ginsenoside Rg on platelet aggregation and its mechanism of action
    • Lee SR, Park JH, Choi KJ, Kim ND. Inhibitory effects of ginsenoside Rg on platelet aggregation and its mechanism of action. Korean J Ginseng Sci 1997;21:12-140.
    • (1997) Korean J Ginseng Sci , vol.21 , pp. 12-140
    • Lee, S.R.1    Park, J.H.2    Choi, K.J.3    Kim, N.D.4
  • 36
    • 0036225172 scopus 로고    scopus 로고
    • A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition
    • Pace-Asciak CR, Reynaud D, Demin P, Aslam R, Sun A. A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition. J Pharmacol Exp Ther 2002;01:618-624.
    • (2002) J Pharmacol Exp Ther , vol.1 , pp. 618-624
    • Pace-Asciak, C.R.1    Reynaud, D.2    Demin, P.3    Aslam, R.4    Sun, A.5
  • 37
    • 10444240971 scopus 로고    scopus 로고
    • G1-mediated signaling as a potential target for antiplatelet drugs
    • Moers A, Wettschureck N, Offermanns S. G1-mediated signaling as a potential target for antiplatelet drugs. Drug News Perspect 2004;17:49-498.
    • (2004) Drug News Perspect , vol.17 , pp. 49-498
    • Moers, A.1    Wettschureck, N.2    Offermanns, S.3
  • 38
    • 79960460286 scopus 로고    scopus 로고
    • Dietary spinach saponin-enriched lipophilic fraction inhibits platelet aggregation and blood coagulation
    • Cho HJ, Choi SA, Kim CG, Hong JH, Park HJ, Park HJ. Dietary spinach saponin-enriched lipophilic fraction inhibits platelet aggregation and blood coagulation. J Med Food 2011;14:784-791.
    • (2011) J Med Food , vol.14 , pp. 784-791
    • Cho, H.J.1    Choi, S.A.2    Kim, C.G.3    Hong, J.H.4    Park, H.J.5    Park, H.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.