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Volumn 13, Issue 4, 2013, Pages 384-392

WNT5A/JNK signaling regulates pancreatic cancer cells migration by Phosphorylating Paxillin

Author keywords

Migration; Pancreatic cancer cell; Paxillin; WNT5A JNK signaling

Indexed keywords

GELATINASE A; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; PAXILLIN; SERINE; STRESS ACTIVATED PROTEIN KINASE 1; UVOMORULIN; VIMENTIN; WNT5A PROTEIN;

EID: 84884704736     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2013.05.008     Document Type: Article
Times cited : (28)

References (26)
  • 1
    • 39749183343 scopus 로고    scopus 로고
    • Analysis of mortality rates for pancreatic cancer across the world
    • Hariharan D, Saied A, Kocher HM. Analysis of mortality rates for pancreatic cancer across the world. HPB (Oxford) 2008;10:58-62.
    • (2008) HPB (Oxford) , vol.10 , pp. 58-62
    • Hariharan, D.1    Saied, A.2    Kocher, H.M.3
  • 2
    • 40149102038 scopus 로고    scopus 로고
    • Kai1 is a potential target for antimetastasis in pancreatic cancer cells
    • Xu JH, Guo XZ, Ren LN, Shao LC, Liu MP. Kai1 is a potential target for antimetastasis in pancreatic cancer cells. World J Gastroenterol 2008;14: 1126-32.
    • (2008) World J Gastroenterol , vol.14 , pp. 1126-1132
    • Xu, J.H.1    Guo, X.Z.2    Ren, L.N.3    Shao, L.C.4    Liu, M.P.5
  • 3
    • 34250685355 scopus 로고    scopus 로고
    • Interaction between cancer cells and stromal fibroblasts is required for activation of the upar-upa-mmp-2 cascade in pancreatic cancer metastasis
    • He Y, Liu XD, Chen ZY, Zhu J, Xiong Y, Li K, et al. Interaction between cancer cells and stromal fibroblasts is required for activation of the upar-upa-mmp-2 cascade in pancreatic cancer metastasis. Clin Cancer Res 2007;13:3115-24.
    • (2007) Clin Cancer Res , vol.13 , pp. 3115-3124
    • He, Y.1    Liu, X.D.2    Chen, Z.Y.3    Zhu, J.4    Xiong, Y.5    Li, K.6
  • 4
    • 0035902805 scopus 로고    scopus 로고
    • Enhanced vegf production and decreased immunogenicity induced by tgf-beta 1 promote liver metastasis of pancreatic cancer
    • Teraoka H, Sawada T, Nishihara T, Yashiro M, Ohira M, Ishikawa T, et al. Enhanced vegf production and decreased immunogenicity induced by tgf-beta 1 promote liver metastasis of pancreatic cancer. Br J Cancer 2001;85:612-7.
    • (2001) Br J Cancer , vol.85 , pp. 612-617
    • Teraoka, H.1    Sawada, T.2    Nishihara, T.3    Yashiro, M.4    Ohira, M.5    Ishikawa, T.6
  • 5
    • 33845352082 scopus 로고    scopus 로고
    • Wnts as ligands: Processing, secretion and reception
    • Mikels AJ, Nusse R. Wnts as ligands: processing, secretion and reception. Oncogene 2006;25:7461-8.
    • (2006) Oncogene , vol.25 , pp. 7461-7748
    • Mikels, A.J.1    Nusse, R.2
  • 6
    • 0027965236 scopus 로고
    • Differential transformation of mammary epithelial cells by wnt genes
    • Wong GT, Gavin BJ, McMahon AP. Differential transformation of mammary epithelial cells by wnt genes. Mol Cell Biol 1994;14:6278-86.
    • (1994) Mol Cell Biol , vol.14 , pp. 6278-6286
    • Wong, G.T.1    Gavin, B.J.2    McMahon, A.P.3
  • 7
    • 39749108763 scopus 로고    scopus 로고
    • The complex pathways of wnt 5a in cancer progression
    • Pukrop T, Binder C. The complex pathways of wnt 5a in cancer progression. J Mol Med (Berl) 2008;86:259-66.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 259-266
    • Pukrop, T.1    Binder, C.2
  • 8
    • 84875168586 scopus 로고    scopus 로고
    • The small gtpase arf6 stimulates beta-catenin transcriptional activity during wnt5a-mediated melanoma invasion and metastasis
    • Grossmann AH, Yoo JH, Clancy J, Sorensen LK, Sedgwick A, Tong Z, et al. The small gtpase arf6 stimulates beta-catenin transcriptional activity during wnt5a-mediated melanoma invasion and metastasis. Sci Signal 2013;6:ra14.
    • (2013) Sci Signal , vol.6
    • Grossmann, A.H.1    Yoo, J.H.2    Clancy, J.3    Sorensen, L.K.4    Sedgwick, A.5    Tong, Z.6
  • 9
    • 84856862398 scopus 로고    scopus 로고
    • An anti-wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis
    • Hanaki H, Yamamoto H, Sakane H, Matsumoto S, Ohdan H, Sato A, et al. An anti-wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. Mol Cancer Ther 2012;11: 298-307.
    • (2012) Mol Cancer Ther , vol.11 , pp. 298-307
    • Hanaki, H.1    Yamamoto, H.2    Sakane, H.3    Matsumoto, S.4    Ohdan, H.5    Sato, A.6
  • 10
    • 34447326176 scopus 로고    scopus 로고
    • Wnt5ae target of cutl1 and potent modulator of tumor cell migration and invasion in pancreatic cancer
    • Ripka S, Konig A, Buchholz M, Wagner M, Sipos B, Kloppel G, et al. Wnt5ae target of cutl1 and potent modulator of tumor cell migration and invasion in pancreatic cancer. Carcinogenesis 2007;28:1178-87.
    • (2007) Carcinogenesis , vol.28 , pp. 1178-1187
    • Ripka, S.1    Konig, A.2    Buchholz, M.3    Wagner, M.4    Sipos, B.5    Kloppel, G.6
  • 11
    • 0035476836 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factorstimulated signaling promoting the migration of invasive human carcinoma cells
    • Hauck CR, Sieg DJ, Hsia DA, Loftus JC, Gaarde WA, Monia BP, et al. Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factorstimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res 2001;61:7079-90.
    • (2001) Cancer Res , vol.61 , pp. 7079-7190
    • Hauck, C.R.1    Sieg, D.J.2    Hsia, D.A.3    Loftus, J.C.4    Gaarde, W.A.5    Monia, B.P.6
  • 12
    • 81055127013 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase by pf-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment
    • Stokes JB, Adair SJ, Slack-Davis JK, Walters DM, Tilghman RW, Hershey ED, et al. Inhibition of focal adhesion kinase by pf-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther 2011;10:2135-45.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2135-2145
    • Stokes, J.B.1    Adair, S.J.2    Slack-Davis, J.K.3    Walters, D.M.4    Tilghman, R.W.5    Hershey, E.D.6
  • 14
    • 79951896236 scopus 로고    scopus 로고
    • Critical role of wnt5a-ror2 signaling in motility and invasiveness of carcinoma cells following snail-mediated epithelialmesenchymal transition
    • Ren D, Minami Y, Nishita M. Critical role of wnt5a-ror2 signaling in motility and invasiveness of carcinoma cells following snail-mediated epithelialmesenchymal transition. Genes Cells 2011;16:304-15.
    • (2011) Genes Cells , vol.16 , pp. 304-315
    • Ren, D.1    Minami, Y.2    Nishita, M.3
  • 16
    • 1942501702 scopus 로고    scopus 로고
    • Overexpression of id-1 is significantly associated with tumour angiogenesis in human pancreas cancers
    • Lee KT, Lee YW, Lee JK, Choi SH, Rhee JC, Paik SS, et al. Overexpression of id-1 is significantly associated with tumour angiogenesis in human pancreas cancers. Br J Cancer 2004;90:1198-203.
    • (2004) Br J Cancer , vol.90 , pp. 1198-1203
    • Lee, K.T.1    Lee, Y.W.2    Lee, J.K.3    Choi, S.H.4    Rhee, J.C.5    Paik, S.S.6
  • 17
    • 27644543932 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation
    • Sawai H, Okada Y, Funahashi H, Matsuo Y, Takahashi H, Takeyama H, et al. Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol Cancer 2005;4:37.
    • (2005) Mol Cancer , vol.4 , pp. 37
    • Sawai, H.1    Okada, Y.2    Funahashi, H.3    Matsuo, Y.4    Takahashi, H.5    Takeyama, H.6
  • 18
    • 51049099174 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin: A novel suppressor of invasion and angiogenesis in pancreatic cancer
    • Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, et al. Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res 2008;68:6100-8.
    • (2008) Cancer Res , vol.68 , pp. 6100-6108
    • Tong, Z.1    Kunnumakkara, A.B.2    Wang, H.3    Matsuo, Y.4    Diagaradjane, P.5    Harikumar, K.B.6
  • 19
    • 0036583231 scopus 로고    scopus 로고
    • Frequent up-regulation of wnt5a mrna in primary gastric cancer
    • Saitoh T, Mine T, Katoh M. Frequent up-regulation of wnt5a mrna in primary gastric cancer. Int J Mol Med 2002;9:515-9.
    • (2002) Int J Mol Med , vol.9 , pp. 515-519
    • Saitoh, T.1    Mine, T.2    Katoh, M.3
  • 20
    • 33644833865 scopus 로고    scopus 로고
    • Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factorean expression in non-small-cell lung cancer
    • Huang CL, Liu D, Nakano J, Ishikawa S, Kontani K, Yokomise H, et al. Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factorean expression in non-small-cell lung cancer. J Clin Oncol 2005;23:8765-73.
    • (2005) J Clin Oncol , vol.23 , pp. 8765-8773
    • Huang, C.L.1    Liu, D.2    Nakano, J.3    Ishikawa, S.4    Kontani, K.5    Yokomise, H.6
  • 21
    • 0030942879 scopus 로고    scopus 로고
    • Expression and hormone regulation of wnt2, 3,4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma
    • Bui TD, Zhang L, Rees MC, Bicknell R, Harris AL. Expression and hormone regulation of wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Br J Cancer 1997;75:1131-6.
    • (1997) Br J Cancer , vol.75 , pp. 1131-1136
    • Bui, T.D.1    Zhang, L.2    Rees, M.C.3    Bicknell, R.4    Harris, A.L.5
  • 23
    • 33645774667 scopus 로고    scopus 로고
    • Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines
    • Pukrop T, Klemm F, Hagemann T, Gradl D, Schulz M, Siemes S, et al. Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci U S A 2006;103:5454-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5454-5459
    • Pukrop, T.1    Klemm, F.2    Hagemann, T.3    Gradl, D.4    Schulz, M.5    Siemes, S.6
  • 24
    • 52149121370 scopus 로고    scopus 로고
    • Jnk regulates cell migration through promotion of tyrosine phosphorylation of paxillin
    • Huang Z, Yan DP, Ge BX. Jnk regulates cell migration through promotion of tyrosine phosphorylation of paxillin. Cell Signal 2008;20:2002-12.
    • (2008) Cell Signal , vol.20 , pp. 2002-2012
    • Huang, Z.1    Yan, D.P.2    Ge, B.X.3
  • 25
    • 77953539908 scopus 로고    scopus 로고
    • Cell/tissue-tropic functions of wnt5a signaling in normal and cancer cells
    • Nishita M, Enomoto M, Yamagata K, Minami Y. Cell/tissue-tropic functions of wnt5a signaling in normal and cancer cells. Trends Cell Biol 2010;20: 346-54.
    • (2010) Trends Cell Biol , vol.20 , pp. 346-354
    • Nishita, M.1    Enomoto, M.2    Yamagata, K.3    Minami, Y.4
  • 26
    • 77954365864 scopus 로고    scopus 로고
    • Ror2/frizzled complex mediates wnt5a-induced ap-1 activation by regulating dishevelled polymerization
    • Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, Inaba D, et al. Ror2/frizzled complex mediates wnt5a-induced ap-1 activation by regulating dishevelled polymerization. Mol Cell Biol 2010;30:3610-9.
    • (2010) Mol Cell Biol , vol.30 , pp. 3610-3619
    • Nishita, M.1    Itsukushima, S.2    Nomachi, A.3    Endo, M.4    Wang, Z.5    Inaba, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.