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Volumn 96, Issue 5, 2014, Pages 895-905

Tlr4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+Tregsduring intestinal inflammation

Author keywords

Colitis; LPS; MyD88; SOCS3

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; NEUROPILIN 1; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; SOCS3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING; TICAM-1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; VESICULAR TRANSPORT ADAPTOR PROTEIN; ZFPN1A2 PROTEIN, MOUSE;

EID: 84908282956     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.3A0114-056RR     Document Type: Article
Times cited : (39)

References (46)
  • 1
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat
    • Fontenot, J. D., Gavin, M. A., Rudensky, A. Y. (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330–336.
    • (2003) Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 2
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat
    • Khattri, R., Cox, T., Yasayko, S. A., Ramsdell, F. (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337–342.
    • (2003) Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 3
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells. Nat
    • Bluestone, J. A., Abbas, A. K. (2003) Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3, 253–257.
    • (2003) Rev. Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 5
    • 79958130907 scopus 로고    scopus 로고
    • Interleukin- 12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis
    • Feng, T., Cao, A. T., Weaver, C. T., Elson, C. O., Cong, Y. (2011) Interleukin- 12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis. Gastroenterology 140, 2031–2043.
    • (2011) Gastroenterology , vol.140 , pp. 2031-2043
    • Feng, T.1    Cao, A.T.2    Weaver, C.T.3    Elson, C.O.4    Cong, Y.5
  • 6
    • 33745275219 scopus 로고    scopus 로고
    • Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm
    • Holmen, N., Lundgren, A., Lundin, S., Bergin, A. M., Rudin, A., Sjovall, H., Ohman, L. (2006) Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm. Bowel Dis. 12, 447–456.
    • (2006) Bowel Dis , vol.12 , pp. 447-456
    • Holmen, N.1    Lundgren, A.2    Lundin, S.3    Bergin, A.M.4    Rudin, A.5    Sjovall, H.6    Ohman, L.7
  • 7
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells induce CD4+CD25–Foxp3–T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β
    • Xu, L., Kitani, A., Fuss, I., Strober, W. (2007) Cutting edge: regulatory T cells induce CD4+CD25–Foxp3–T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β J. Immunol. 178, 6725–6729.
    • (2007) J. Immunol , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 8
    • 79952300978 scopus 로고    scopus 로고
    • Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases
    • Hovhannisyan, Z., Treatman, J., Littman, D. R., Mayer, L. (2011) Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology 140, 957–965.
    • (2011) Gastroenterology , vol.140 , pp. 957-965
    • Hovhannisyan, Z.1    Treatman, J.2    Littman, D.R.3    Mayer, L.4
  • 11
    • 80052680230 scopus 로고    scopus 로고
    • Contrasting effects of TNF and anti- TNF on the activation of effector T cells and regulatory T cells in autoimmunity
    • Chen, X., Oppenheim, J. J. (2011) Contrasting effects of TNF and anti- TNF on the activation of effector T cells and regulatory T cells in autoimmunity. FEBS Lett. 585, 3611–3618.
    • (2011) FEBS Lett , vol.585 , pp. 3611-3618
    • Chen, X.1    Oppenheim, J.J.2
  • 12
    • 77951060733 scopus 로고    scopus 로고
    • OX40 is required for regulatory T cell-mediated control of colitis
    • Griseri, T., Asquith, M., Thompson, C., Powrie, F. (2010) OX40 is required for regulatory T cell-mediated control of colitis. J. Exp. Med. 207, 699–709.
    • (2010) J. Exp. Med , vol.207 , pp. 699-709
    • Griseri, T.1    Asquith, M.2    Thompson, C.3    Powrie, F.4
  • 14
    • 84872690335 scopus 로고    scopus 로고
    • TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment
    • Chen, X., Wu, X., Zhou, Q., Howard, O. M., Netea, M. G., Oppenheim, J. J. (2013) TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment. J. Immunol. 190, 1076–1084.
    • (2013) J. Immunol , vol.190 , pp. 1076-1084
    • Chen, X.1    Wu, X.2    Zhou, Q.3    Howard, O.M.4    Netea, M.G.5    Oppenheim, J.J.6
  • 16
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz, S. Z., Rudensky, A. (2009) Control of regulatory T cell lineage commitment and maintenance. Immunity 30, 616–625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 18
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., Campbell, D. J. (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595–602.
    • (2009) Nat. Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 19
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer’s patches
    • Tsuji, M., Komatsu, N., Kawamoto, S., Suzuki, K., Kanagawa, O., Honjo, T., Hori, S., Fagarasan, S. (2009) Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer’s patches. Science 323, 1488–1492.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6    Hori, S.7    Fagarasan, S.8
  • 20
    • 33745851174 scopus 로고    scopus 로고
    • Toll-like receptors on regulatory T cells: Expanding immune regulation
    • Sutmuller, R. P., Morgan, M. E., Netea, M. G., Grauer, O., Adema, G. J. (2006) Toll-like receptors on regulatory T cells: expanding immune regulation. Trends Immunol. 27, 387–393.
    • (2006) Trends Immunol , vol.27 , pp. 387-393
    • Sutmuller, R.P.1    Morgan, M.E.2    Netea, M.G.3    Grauer, O.4    Adema, G.J.5
  • 24
    • 40749120555 scopus 로고    scopus 로고
    • The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease
    • Fukata, M., Breglio, K., Chen, A., Vamadevan, A. S., Goo, T., Hsu, D., Conduah, D., Xu, R., Abreu, M. T. (2008) The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J. Immunol. 180, 1886–1894.
    • (2008) J. Immunol , vol.180 , pp. 1886-1894
    • Fukata, M.1    Breglio, K.2    Chen, A.3    Vamadevan, A.S.4    Goo, T.5    Hsu, D.6    Conduah, D.7    Xu, R.8    Abreu, M.T.9
  • 28
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton, A. M., Korty, P. E., Tran, D. Q., Wohlfert, E. A., Murray, P. E., Belkaid, Y., Shevach, E. M. (2010) Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 184, 3433–3441.
    • (2010) J. Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6    Shevach, E.M.7
  • 30
    • 73349099737 scopus 로고    scopus 로고
    • A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
    • Cong, Y., Feng, T., Fujihashi, K., Schoeb, T. R., Elson, C. O. (2009) A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc. Natl. Acad. Sci. USA 106, 19256–19261.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 19256-19261
    • Cong, Y.1    Feng, T.2    Fujihashi, K.3    Schoeb, T.R.4    Elson, C.O.5
  • 31
    • 79960935591 scopus 로고    scopus 로고
    • Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn’s disease model
    • Radi, Z. A., Heuvelman, D. M., Masferrer, J. L., Benson, E. L. (2011) Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn’s disease model. Dig. Dis. Sci. 56, 2283–2291.
    • (2011) Dig. Dis. Sci , vol.56 , pp. 2283-2291
    • Radi, Z.A.1    Heuvelman, D.M.2    Masferrer, J.L.3    Benson, E.L.4
  • 33
    • 0033197958 scopus 로고    scopus 로고
    • Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-_
    • Stoiber, D., Kovarik, P., Cohney, S., Johnston, J. A., Steinlein, P., Decker, T. (1999) Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-_. J. Immunol. 163, 2640–2647.
    • (1999) J. Immunol , vol.163 , pp. 2640-2647
    • Stoiber, D.1    Kovarik, P.2    Cohney, S.3    Johnston, J.A.4    Steinlein, P.5    Decker, T.6
  • 34
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide
    • Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M., Demengeot, J. (2003) Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197, 403–411.
    • (2003) J. Exp. Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 35
    • 46949091694 scopus 로고    scopus 로고
    • Toll-like receptor signalling on Tregs: To suppress or not to suppress?
    • van Maren, W. W., Jacobs, J. F., de Vries, I. J., Nierkens, S., Adema, G. J. (2008) Toll-like receptor signalling on Tregs: to suppress or not to suppress? Immunology 124, 445–452.
    • (2008) Immunology , vol.124 , pp. 445-452
    • Van Maren, W.W.1    Jacobs, J.F.2    De Vries, I.J.3    Nierkens, S.4    Adema, G.J.5
  • 36
    • 84883737369 scopus 로고    scopus 로고
    • Peripheral and thymic foxp3(+) regulatory T cells in search of origin, distinction, and function. Front
    • Dhamne, C., Chung, Y., Alousi, A. M., Cooper, L. J., Tran, D. Q. (2013) Peripheral and thymic foxp3(+) regulatory T cells in search of origin, distinction, and function. Front. Immunol. 4, 253.
    • (2013) Immunol , vol.4 , pp. 253
    • Dhamne, C.1    Chung, Y.2    Alousi, A.M.3    Cooper, L.J.4    Tran, D.Q.5
  • 37
    • 84883679673 scopus 로고    scopus 로고
    • Peripherally induced Tregs—role in immune homeostasis and autoimmunity. Front
    • Yadav, M., Stephan, S., Bluestone, J. A. (2013) Peripherally induced Tregs—role in immune homeostasis and autoimmunity. Front. Immunol. 4, 232.
    • (2013) Immunol , vol.4 , pp. 232
    • Yadav, M.1    Stephan, S.2    Bluestone, J.A.3
  • 39
    • 80955181118 scopus 로고    scopus 로고
    • Moving to tolerance: clinical application of T regulatory cells
    • McMurchy, A. N., Bushell, A., Levings, M. K., Wood, K. J. (2011) Moving to tolerance: clinical application of T regulatory cells. Semin. Immunol. 23, 304–313.
    • (2011) Semin. Immunol , vol.23 , pp. 304-313
    • McMurchy, A.N.1    Bushell, A.2    Levings, M.K.3    Wood, K.J.4
  • 40
    • 32644482551 scopus 로고    scopus 로고
    • Clinical application of expanded CD4+25+ cells. Semin
    • June, C. H., Blazar, B. R. (2006) Clinical application of expanded CD4+25+ cells. Semin. Immunol. 18, 78–88.
    • (2006) Immunol , vol.18 , pp. 78-88
    • June, C.H.1    Blazar, B.R.2
  • 41
    • 65549127618 scopus 로고    scopus 로고
    • Human T regulatory cell therapy: Take a billion or so and call me in the morning
    • Riley, J. L., June, C. H., Blazar, B. R. (2009) Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 30, 656–665.
    • (2009) Immunity , vol.30 , pp. 656-665
    • Riley, J.L.1    June, C.H.2    Blazar, B.R.3
  • 43
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., Medzhitov, R. (2004) Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229–241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 44
    • 84864700392 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation
    • Reynolds, J. M., Martinez, G. J., Chung, Y., Dong, C. (2012) Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation. Proc. Natl. Acad. Sci. USA 109, 13064–13069.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 13064-13069
    • Reynolds, J.M.1    Martinez, G.J.2    Chung, Y.3    Dong, C.4
  • 45
    • 47249166438 scopus 로고    scopus 로고
    • Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-+ are resistant to Th17 conversion by IL-6
    • Zheng, S. G., Wang, J., Horwitz, D. A. (2008) Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-+ are resistant to Th17 conversion by IL-6. J. Immunol. 180, 7112–7116.
    • (2008) J. Immunol , vol.180 , pp. 7112-7116
    • Zheng, S.G.1    Wang, J.2    Horwitz, D.A.3
  • 46
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C., Medzhitov, R. (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033–1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2


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