Greater daily defined dose of antihypertensive medication increases the risk of falls in older people - A population-based study

Journal of the American Geriatrics Society

Volumn 62, Issue 8, 2014, Pages 1527-1533

  Callisaya, Michele L ^a,b   Sharman, James E ^b   Close, Jacqueline ^c,d   Lord, Stephen R ^c,d   Srikanth, Velandai K ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF TASMANIA   (Australia)

^c NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

antihypertensive medication; falls; older people

Indexed keywords

ANTIHYPERTENSIVE MEDICATION; FALLS; OLDER PEOPLE;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; FEMALE; GERIATRIC ASSESSMENT; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; TASMANIA;

EID: 84906090775     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.12925     Document Type: Article

References (30)

1. Callisaya ML, Blizzard L, Schmidt MD, et al. Gait, gait variability and the risk of multiple incident falls in older people: A population-based study. Age Ageing 2011; 40: 481-487.
2. Campbell AJ, Borrie MJ, Spears GF, et al. Circumstances and consequences of falls experienced by a community population 70 years and over during a prospective study. Age Ageing 1990; 19: 136-141.
3. Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 2009; 169: 1952-1960.
4. Campbell AJ,. Drug treatment as a cause of falls in old age. A review of the offending agents. Drugs Aging 1991; 1: 289-302.
5. Chu LW, Chi I, Chiu AY,. Incidence and predictors of falls in the Chinese elderly. Ann Acad Med Singapore 2005; 34: 60-72.
6. Frels C, Williams P, Narayanan S, et al. Iatrogenic causes of falls in hospitalised elderly patients: A case-control study. Postgrad Med J 2002; 78: 487-489.
7. Gerdhem P, Ringsberg KA, Akesson K, et al. Clinical history and biologic age predicted falls better than objective functional tests. J Clin Epidemiol 2005; 58: 226-232.
8. Lee JS, Kwok T, Leung PC, et al. Medical illnesses are more important than medications as risk factors of falls in older community dwellers? A cross-sectional study Age Ageing 2006; 35: 246-251.
9. Wong AK, Lord SR, Sturnieks DL, et al. Angiotensin system-blocking medications are associated with fewer falls over 12 months in community-dwelling older people. J Am Geriatr Soc 2013; 61: 776-781.
10. Gribbin J, Hubbard R, Gladman J, et al. Risk of falls associated with antihypertensive medication: Self-controlled case series. Pharmacoepidemiol Drug Saf 2011; 20: 879-884.
11. Bergland A, Wyller TB,. Risk factors for serious fall related injury in elderly women living at home. Inj Prev 2004; 10: 308-313.
12. Rozenfeld S, Camacho LA, Veras P,. Medication as a risk factor for falls in older women in Brazil. Rev Panam Salud Publica 2003; 13: 369-375.
13. Tromp AM, Smit JH, Deeg DJ, et al. Predictors for falls and fractures in the Longitudinal Aging Study Amsterdam. J Bone Miner Res 1998; 13: 1932-1939.
14. Butt DA, Mamdani M, Austin PC, et al. The risk of falls on initiation of antihypertensive drugs in the elderly. Osteoporos Int 2013; 24: 2649-2657.
15. Butt DA, Mamdani M, Austin PC, et al. The risk of hip fracture after initiating antihypertensive drugs in the elderly. Arch Intern Med 2012; 172: 1739-1744.
16. WHO Collaborating Centre for Drug Statistics Methodology. Daily defined dose: Definition and general considerations [online]. Available at http://www.whocc.no/ddd/definition-and-general-considera/ Accessed March 16, 2013.
17. Lamb SE, Jorstad-Stein EC, Hauer K, et al. Development of a common outcome data set for fall injury prevention trials: The Prevention of Falls Network Europe consensus. J Am Geriatr Soc 2005; 53: 1618-1622.
18. Spreen O, Strauss E,. A Compendium of Neuropsychological Tests. Administration, Norms, and Commentary, 2nd Ed. New York: Oxford University Press, 1998.
19. Wechsler D,. Wechsler Adult Intelligence Scale. New York, NY: Psychological Corporation, 1997.
20. Lezak M,. Neuropsychological Assessment, 3rd Ed. New York: Oxford University Press, 1995.
21. Martin KL, Blizzard L, Srikanth VK, et al. Cognitive function modifies the effect of physiological function on the risk of multiple falls-a population-based study. J Gerontol A Biol Sci Med Sci 2013; 68A: 1091-1097.
22. Lord SR, Menz HB, Tiedemann A,. A physiological profile approach to falls risk assessment and prevention. Phys Ther 2003; 83: 237-252.
23. Hawthorne G, Richardson J, Osborne R,. The Assessment of Quality of Life (AQoL) instrument: A psychometric measure of health-related quality of life. Qual Life Res 1999; 8: 209-224.
24. Campbell AJ, Borrie MJ, Spears GF,. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989; 44: M112-M117.
25. Cumming RG, Miller JP, Kelsey JL, et al. Medications and multiple falls in elderly people: The St. Louis OASIS study. Age Ageing 1991; 20: 455-461.
26. Leipzig RM, Cumming RG, Tinetti ME,. Drugs and falls in older people: A systematic review and meta-analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc 1999; 47: 40-50.
27. Batchelor FA, Mackintosh SF, Said CM, et al. Falls after stroke. Int J Stroke 2012; 7: 482-490.
28. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31: 1281-1357.
29. van der Velde N, Stricker BH, Pols HA, et al. Risk of falls after withdrawal of fall-risk-increasing drugs: A prospective cohort study. Br J Clin Pharmacol 2007; 63: 232-237.
30. Tinetti ME, McAvay GJ, Fried TR, et al. Health outcome priorities among competing cardiovascular, fall injury, and medication-related symptom outcomes. J Am Geriatr Soc 2008; 56: 1409-1416.