CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

Journal of Experimental Medicine

Volumn 211, Issue 11, 2014, Pages 2307-2321

  Jia, Xin Ming ^a   Tang, Bing ^b   Zhu, Le Le ^a   Liu, Yan Hui ^a   Zhao, Xue Qiang ^c   Gorjestani, Sara ^c   Hsu, Yen Michael S ^c   Yang, Long ^a   Guan, Jian Hong ^a   Xu, Guo Tong ^a   Lin, Xin ^c  

^a Key Laboratory of Arrhythmias of Ministry of Education   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BETA GLUCAN; CASPASE RECRUITMENT DOMAIN CONTAINING PROTEIN 9; CURDLAN; DECTIN 1; DECTIN 2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; H RAS PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE SYK; RAS PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CARD9 PROTEIN, HUMAN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; LECTIN; MULTIPROTEIN COMPLEX; PROTEIN BINDING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FEMALE; FUNGUS IMMUNITY; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; INVASIVE CANDIDIASIS; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CANDIDIASIS; DRUG EFFECTS; FUNGUS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MORTALITY; MYCOSIS;

ANIMALS; BETA-GLUCANS; CANDIDA ALBICANS; CANDIDIASIS; CARD SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FUNGI; HUMANS; IMMUNITY, INNATE; LECTINS, C-TYPE; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; MYCOSES; NF-KAPPA B; PROTEIN BINDING; RAS PROTEINS; RAS-GRF1; SIGNAL TRANSDUCTION;

EID: 84908229513     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20132349     Document Type: Article

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